Hasil Pencarian  ::  Simpan CSV :: Kembali

"The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. "

"The volumes present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.Volumes 1 and 2 are devoted to cell organization and fate, as well as activities that are autoregulated and/or controlled by the cell environment. Volume 1 examined cellular features that allow adaptation to environmental conditions. Volume 2 begins with a survey of the cell types of the nervous and endocrine systems involved in the regulation of the vasculature and respiratory tract and growth factors. It then describes major cell events in the circulatory and ventilatory systems, such as cell growth, proliferation, migration, and death. Circadian cycles that drive rhythmic gene transcription are also covered."

"Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm."

"In this book, experts from the field of intercellular transport deal with various aspects on intercellular transport of viruses and plant endogenous macromolecules such as transcription factors, small silencing-induced and micro RNAs, and other RNAs and their function as signals. The aim of the book is to provide the basic information on the cell-to-cell transport mechanism and to give an overview of the current knowledge of this relatively new field of research. "

""Relevant to both research and clinical practice, this rich resource covers key principles of cellular function and uses them to explain how molecular defects lead to cellular dysfunction and cause human disease." -- Back cover."

"This volume covers topics ranging from fundamental aspects of calcium signaling to its clinical implications, in a thoughtful and comprehensive way. It includes discussion of calcium signaling in different mammalian cells, oocytes, zebrafishes and even in plants."

"This book provides an overview of critical components of cell signaling machinery and its role in epithelial morphogenesis, proliferation, invasions and angiogenesis in human cancer and discusses novel types of protein kinase pathways."

"The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. "