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"ABSTRAK Odontocem® dan Biodentine®, berbahan dasar kalsium silikat. Tetapi terdapat kandungan lain yang mungkin memiliki efek pada viabiltas sel. Contohnya penambahan steroid dalam Odontocem®. Belum diketahui apakah penambahan steroid tersebut memiliki efek atau tidak terhadap viabilitas sel. Sel fibroblas yang diambil dari Telur Embrio Tertunas (TET), dipajan dengan Odontocem® dan Biodentine® dengan jumlah masing-masing kelompok sebesar 15 well. Kemudian viabilitas sel diukur selama 24 jam dan 72 jam. Hasil penelitian diuji dengan uji statistik Kruskal Wallis dengan uji post hoc Mann-Whitney. Berdasarkan hasil penelitian, didapatkan bahwa Odontocem® dan Biodentine® memiliki efek menurunkan viabiltas sel fibroblas pada pengukuran 24 jam dan 72 jam. Juga viabilitas sel fibroblas pada kelompok perlakuan Odontocem ® lebih tinggi daripada Biodentine® baik pada pengukuran 24 jam maupun 72 jam. ABSTRACT Odontocem® and Biodentine®, both consist of calcium silicate. But there are other substances which may have an effect on cell viability. For example, addition of steroids in Odontocem®. It is not yet known whether these steroids have an effect or not on the cell viability. Fibroblasts taken from Chicken Embryo, added with Odontocem® and Biodentine® by each group of 15 wells. Then the cell viability was measured for 24 hours and 72 hours. The result were tested by Kruskal Wallis statistical test with post hoc test of Mann-Whitney. Based on this research, it was found that Odontocem® and Biodentine® have a lowering effect on the fibroblast cell viability for 24 hours and 72 hours. Thus, fibroblast cell viability the treatment group Odontocem ® is higher than both the measurement Biodentine® 24 hours or 72 hours.;Odontocem® and Biodentine®, both consist of calcium silicate. But there are other substances which may have an effect on cell viability. For example, addition of steroids in Odontocem®. It is not yet known whether these steroids have an effect or not on the cell viability. Fibroblasts taken from Chicken Embryo, added with Odontocem® and Biodentine® by each group of 15 wells. Then the cell viability was measured for 24 hours and 72 hours. The result were tested by Kruskal Wallis statistical test with post hoc test of Mann-Whitney. Based on this research, it was found that Odontocem® and Biodentine® have a lowering effect on the fibroblast cell viability for 24 hours and 72 hours. Thus, fibroblast cell viability the treatment group Odontocem ® is higher than both the measurement Biodentine® 24 hours or 72 hours."

"ABSTRAK Latar Belakang: siler polidimetilsiloksan merupakan siler baru yang berpotensi menutup saluran akar lebih baik. Tujuan: membandingkan tingkat kerapatanpengisian di sepertiga apeks antara teknik kon tunggal (KT) dan downpackbackfill(DB) menggunakan siler polidimetilsiloksan. Metode: empat puluh gigipremolar bawah dibagi menjadi dua kelompok KT dan DB. Setelah pengisiansaluran akar, sampel diinkubasi, dilapisi cat kuku, direndam dalam tinta India, laludibuat transparan dengan metode Robertson. Kebocoran di sepertiga apeksdievaluasi dengan mikroskop stereo. Hasil: skor kebocoran terendah (0-0,5 mm)dimiliki oleh kelompok KT dan skor kebocoran tertinggi (>1 mm) dimiliki olehkelompok DB. Kesimpulan: teknik kon tunggal memberikan tingkat kerapatanyang lebih baik dibandingkan downpack-backfill, walaupun secara statistik perbedaan antar keduanya tidak signifikan. ABSTRACT Background: polydimethylsiloxane sealer is a brand new sealer that potentiallyhas a better sealing ability to the root canal. Aim: to compare the apical sealingability in one third apex between single cone (SC) and downpack-backfill (DB)technique using polydimethylsiloxane sealer. Methods: fourty extracted humanmanibular premolars devided into two group, SC and DB. After obturated withpolydimethylsiloxane sealer, samples were stored in incubator, coated with nailvarnish, immersed in India ink, and then specimens were cleared usingRobertson?s technique. The apical dye penetration was evaluated using astereomicroscope. Result: the lowest leakage score (0-0,5 mm) was found in SCgroup and the highest score(>1 mm) in DB group. Summary: single conetechnique exibited better sealing ability rather than downpack-backfill technique, although no statistical significant difference between this two techniques. ;Background: polydimethylsiloxane sealer is a brand new sealer that potentiallyhas a better sealing ability to the root canal. Aim: to compare the apical sealingability in one third apex between single cone (SC) and downpack-backfill (DB)technique using polydimethylsiloxane sealer. Methods: fourty extracted humanmanibular premolars devided into two group, SC and DB. After obturated withpolydimethylsiloxane sealer, samples were stored in incubator, coated with nailvarnish, immersed in India ink, and then specimens were cleared usingRobertson?s technique. The apical dye penetration was evaluated using astereomicroscope. Result: the lowest leakage score (0-0,5 mm) was found in SCgroup and the highest score(>1 mm) in DB group. Summary: single conetechnique exibited better sealing ability rather than downpack-backfill technique, although no statistical significant difference between this two techniques. ;Background: polydimethylsiloxane sealer is a brand new sealer that potentiallyhas a better sealing ability to the root canal. Aim: to compare the apical sealingability in one third apex between single cone (SC) and downpack-backfill (DB)technique using polydimethylsiloxane sealer. Methods: fourty extracted humanmanibular premolars devided into two group, SC and DB. After obturated withpolydimethylsiloxane sealer, samples were stored in incubator, coated with nailvarnish, immersed in India ink, and then specimens were cleared usingRobertson?s technique. The apical dye penetration was evaluated using astereomicroscope. Result: the lowest leakage score (0-0,5 mm) was found in SCgroup and the highest score(>1 mm) in DB group. Summary: single conetechnique exibited better sealing ability rather than downpack-backfill technique, although no statistical significant difference between this two techniques. "

"ABSTRAK Latar Belakang: Preparasi saluran akar oval memiliki tantangan tersendiri karenabentuknya yang ireguler sehingga file tidak dapat berkontak dengan seluruhdinding. Penelitian ini bertujuan untuk membandingkan luas dinding saluran akaroval yang tidak terpreparasi dengan gerakan sirkumferensial filing. Metode: Tigapuluh dua gigi premolar mandibula diisi tinta cina kemudian dipreparasi menjadidua kelompok: Mtwo® dan ProTaper Next®. Luas sisa tinta cina dianalisisdengan Adobe Photoshop CS6 dan ImageJ. Hasil: Tidak terdapat perbedaanbermakna antara kedua kelompok, namun ProTaper Next® meninggalkan arealebih sedikit dibandingkan Mtwo®. Kesimpulan: Mtwo® dan ProTaper Next®tetap meninggalkan area yang tidak terpreparasi pada saluran akar oval.ABSTRACT Background: Mechanical preparation of oval root canal has its own challengedue to the irregular shape leaving some area uninstrumented. This studycompared uninstrumented area of oval root canal with circumferential filingusing two different files. Methods: Thirty-two mandibular premolars were dyedwith china ink and divided into two groups, Mtwo® and ProTaper Next®. Theuninstrumented areas were analized using Adobe Photoshop CS6 and ImageJ.Results: There were no significant difference between two files, thou ProTaperNext® left less uninstrumented areas than Mtwo®. Conclusion: Mtwo® andProTaper Next® left uninstrumented areas in oval root canal.;Background: Mechanical preparation of oval root canal has its own challengedue to the irregular shape leaving some area uninstrumented. This studycompared uninstrumented area of oval root canal with circumferential filingusing two different files. Methods: Thirty-two mandibular premolars were dyedwith china ink and divided into two groups, Mtwo® and ProTaper Next®. Theuninstrumented areas were analized using Adobe Photoshop CS6 and ImageJ.Results: There were no significant difference between two files, thou ProTaperNext® left less uninstrumented areas than Mtwo®. Conclusion: Mtwo® andProTaper Next® left uninstrumented areas in oval root canal.;Background: Mechanical preparation of oval root canal has its own challengedue to the irregular shape leaving some area uninstrumented. This studycompared uninstrumented area of oval root canal with circumferential filingusing two different files. Methods: Thirty-two mandibular premolars were dyedwith china ink and divided into two groups, Mtwo® and ProTaper Next®. Theuninstrumented areas were analized using Adobe Photoshop CS6 and ImageJ.Results: There were no significant difference between two files, thou ProTaperNext® left less uninstrumented areas than Mtwo®. Conclusion: Mtwo® andProTaper Next® left uninstrumented areas in oval root canal.;Background: Mechanical preparation of oval root canal has its own challengedue to the irregular shape leaving some area uninstrumented. This studycompared uninstrumented area of oval root canal with circumferential filingusing two different files. Methods: Thirty-two mandibular premolars were dyedwith china ink and divided into two groups, Mtwo® and ProTaper Next®. Theuninstrumented areas were analized using Adobe Photoshop CS6 and ImageJ.Results: There were no significant difference between two files, thou ProTaperNext® left less uninstrumented areas than Mtwo®. Conclusion: Mtwo® andProTaper Next® left uninstrumented areas in oval root canal."

"ABSTRAK Latar Belakang: MTA bersifat biokompatibel dan dapat digunakan untuk perawatan kaping pulpa. Saat ini dikembangkan semen berbasis kalsium silikat sama seperti MTA dengan penambahan steroid, yaitu Odontocem. Tujuan:Membandingkan efek toksisitas odontocem dan MTA-Angelus terhadap viabilitas sel fibroblas. Metode:Sel fibroblast embrio ayam direndam dalam larutan odontocemdan dan MTA-Angeluspada 24 dan 72 jam. Viabilitas sel dihitung menggunakanMTT Assay. Hasil:Pada kelompok odontcemdan MTA-Angelus, terdapat perbedaan bermakna (p≤0,05 ) dibandingkan dengan kontrol. Pada paparan 24 jam, tidak terdapat perbedaan bermakna antara odontocem dengan MTA-Angelus. Kesimpulan:Odontocem dan dan MTA-Angelus menurunkan viabilitas sel pada 24 jam dan meningkatkan pada 72 jam.ABSTRACT Background:MTA is proved tobe biocompatible and can be used for pulp capping treatment.Currently, calcium silicate based cement similar to MTA with steroid,called Odontocem has been developed.Objective:To compare effects of odontocem and MTA-Angelus toxicity towards fibroblast cells viability.Method:Fibroblast cells of chicken embryonic were immersed separately in odontocem and MTA-Angelus solution for 24 and 72 hours.Cells viability was analyzed with MTT Assay.Result:There was a significant difference (p>0.05) in Odontocem and MTA-Angelus group compared to control.At the24-hour immersion, there was nosignificant difference between odontocem and MTA-Angelus.Conclusion:Odontocem and MTA-Angelus decreased the viability of fibroblast at 24 hours and increased them at 72 hours.;Background:MTA is proved tobe biocompatible and can be used for pulp capping treatment.Currently, calcium silicate based cement similar to MTA with steroid,called Odontocem has been developed.Objective:To compare effects of odontocem and MTA-Angelus toxicity towards fibroblast cells viability.Method:Fibroblast cells of chicken embryonic were immersed separately in odontocem and MTA-Angelus solution for 24 and 72 hours.Cells viability was analyzed with MTT Assay.Result:There was a significant difference (p>0.05) in Odontocem and MTA-Angelus group compared to control.At the24-hour immersion, there was nosignificant difference between odontocem and MTA-Angelus.Conclusion:Odontocem and MTA-Angelus decreased the viability of fibroblast at 24 hours and increased them at 72 hours.;Background:MTA is proved tobe biocompatible and can be used for pulp capping treatment.Currently, calcium silicate based cement similar to MTA with steroid,called Odontocem has been developed.Objective:To compare effects of odontocem and MTA-Angelus toxicity towards fibroblast cells viability.Method:Fibroblast cells of chicken embryonic were immersed separately in odontocem and MTA-Angelus solution for 24 and 72 hours.Cells viability was analyzed with MTT Assay.Result:There was a significant difference (p>0.05) in Odontocem and MTA-Angelus group compared to control.At the24-hour immersion, there was nosignificant difference between odontocem and MTA-Angelus.Conclusion:Odontocem and MTA-Angelus decreased the viability of fibroblast at 24 hours and increased them at 72 hours.;Background:MTA is proved tobe biocompatible and can be used for pulp capping treatment.Currently, calcium silicate based cement similar to MTA with steroid,called Odontocem has been developed.Objective:To compare effects of odontocem and MTA-Angelus toxicity towards fibroblast cells viability.Method:Fibroblast cells of chicken embryonic were immersed separately in odontocem and MTA-Angelus solution for 24 and 72 hours.Cells viability was analyzed with MTT Assay.Result:There was a significant difference (p>0.05) in Odontocem and MTA-Angelus group compared to control.At the24-hour immersion, there was nosignificant difference between odontocem and MTA-Angelus.Conclusion:Odontocem and MTA-Angelus decreased the viability of fibroblast at 24 hours and increased them at 72 hours."

"ABSTRAK Saat ini non-alcoholic fatty liver disease (NAFLD) merupakan penyebab terbanyak dari penyakit kronik hati pada anak dan dewasa. Penelitian terbaru memperlihatkan chemerin yang merupakan salah satu zat yang diproduksi oleh jaringan lemak memiliki andil penting pada NAFLD. Tujuan penelitian ini adalah membandingkan kadar chemerin dalam darah dibandingkan enzim transaminase dalam mendeteksi secara dini kerusakan sel hati karena non alcoholic fatty liver disease (NAFLD) pada anak dengan obesitas. Penelitian deskriptif potong lintang (n=57) dilakukan pada 2 buah sekolah di Jakarta pada anak usia 9-12 tahun dengan obesitas. Anak yang masuk kriteria penelitian dilakukan pemeriksaan ultrasonografi hati untuk mendeteksi perlemakan hati. Kedua kelompok tersebut sama sama dilakukan pemeriksan kadar enzim transaminase dan chemerin darah. Hasil dari penelitian ini di dapatkan nilai rerata chemerin pada anak yang menderita NAFLD sebesar 96,71 ng/ml sedangkan yang tidak menderita NAFLD sebesar 92,8 ng/ml dengan P= 0,463. Hal ini menunjukkan nilai rerata anak dengan NAFLD dibandingkan dengan anak tanpa NAFLD tidak terdapat perbedaan bermakna. Pada penelitian ini didapatkan pula bahwa pemeriksaan chemerin darah memiliki nilai AUC 0,52 dimana nilainya lebih rendah dibandingkan nilai AUC pemeriksaan SGOT dan SGPT yakni 0,81 dan 0,90. Hasil ini menunjukkan bahwa kadar chemerin darah tidak dapat menjadi prediktor yang lebih baik untuk mendeteksi perlemakan hati dibandingkan pemeriksaan kadar SGOT dan SGPT pada penelitian ini. Manfaat chemerin sebagai prediktor kelainan hati pada anak dengan obesitas perlu diteliti lebih lanjut. ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in both adults and children. Current studies have shown that chemerin, one of the biologically active substance produced by fat tissue, may have an important role in the progression of NAFLD. The aim of this research was to study whether chemerin is able to predict liver abnormalities due to NAFLD in obese children better than serum transaminases. A cross-sectional descriptive study was conducted in 57 obese subjects 9-12 years of age at 2 elementary schools in Jakarta, Indonesia. Liver ultrasound was performed in eligible subjects to detect fatty liver, along with serum chemerin and serum transaminase tests. Mean chemerin level in NAFLD and non-NAFLD children were 96.71 ng/mL and 92.8 ng/mL (p=0.463), showing no significant difference between serum chemerin level in the NAFLD and non-NAFLD group. The area under the curve (AUC) for serum chemerin was 0.52, lower than the AUC for AST (0.81) and AST (0.90). This shows that serum chemerin is not superior in predicting fatty liver compared to serum transaminase levels in this study. The role of chemerin as a marker to predict liver abnormalities in obese children still needs to be further investigated.;Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in both adults and children. Current studies have shown that chemerin, one of the biologically active substance produced by fat tissue, may have an important role in the progression of NAFLD. The aim of this research was to study whether chemerin is able to predict liver abnormalities due to NAFLD in obese children better than serum transaminases. A cross-sectional descriptive study was conducted in 57 obese subjects 9-12 years of age at 2 elementary schools in Jakarta, Indonesia. Liver ultrasound was performed in eligible subjects to detect fatty liver, along with serum chemerin and serum transaminase tests. Mean chemerin level in NAFLD and non-NAFLD children were 96.71 ng/mL and 92.8 ng/mL (p=0.463), showing no significant difference between serum chemerin level in the NAFLD and non-NAFLD group. The area under the curve (AUC) for serum chemerin was 0.52, lower than the AUC for AST (0.81) and AST (0.90). This shows that serum chemerin is not superior in predicting fatty liver compared to serum transaminase levels in this study. The role of chemerin as a marker to predict liver abnormalities in obese children still needs to be further investigated.;Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in both adults and children. Current studies have shown that chemerin, one of the biologically active substance produced by fat tissue, may have an important role in the progression of NAFLD. The aim of this research was to study whether chemerin is able to predict liver abnormalities due to NAFLD in obese children better than serum transaminases. A cross-sectional descriptive study was conducted in 57 obese subjects 9-12 years of age at 2 elementary schools in Jakarta, Indonesia. Liver ultrasound was performed in eligible subjects to detect fatty liver, along with serum chemerin and serum transaminase tests. Mean chemerin level in NAFLD and non-NAFLD children were 96.71 ng/mL and 92.8 ng/mL (p=0.463), showing no significant difference between serum chemerin level in the NAFLD and non-NAFLD group. The area under the curve (AUC) for serum chemerin was 0.52, lower than the AUC for AST (0.81) and AST (0.90). This shows that serum chemerin is not superior in predicting fatty liver compared to serum transaminase levels in this study. The role of chemerin as a marker to predict liver abnormalities in obese children still needs to be further investigated."

"ABSTRAK Latar Belakang: Berbagai material kaping pulpa berbahan dasar kalsium silikatterus dikembangkan, diantaranya semen berbasis kalsium silikat denganpenambahan steroid. Tujuan: Menganalisis efek penambahan steroid pada semenberbasis kalsium silikat terhadap viabilitas sel fibroblas. Metode: Sel fibroblasembrio ayam direndam dalam ekstrak larutan semen berbasis kalsium silikatdengan penambahan steroid dan MTA. Viabilitas sel dihitung dengan menggunakan uji MTT. Hasil: Terdapat perbedaan bermakna (p ≤ 0,05)viabilitas sel pada kelompok semen berbasis kalsium silikat dengan penambahansteroid dibandingkan kelompok kontrol dan MTA. Kesimpulan: Penambahansteroid menurunkan viabilitas sel. Terdapat peningkatan pada 72 jam, yang menandakan terjadinya proliferasi sel.ABSTRACT Background: Calcium silicate based materials are being developed continuously,one of them is calcium silicate based cement containing steroid. Objective: Toanalyze the effect of steroid addition in calcium silicate based cement onfibroblast cells viability. Methods: Chicken embryonic fibroblast cells wereimmersed in extract solution of calcium silicate based cement containing steroidand MTA. Viability was analyzed by MTT Assay. Results: Significant difference (p ≤ 0,05) of viability on calcium silicate based cement containing steroid groupwas found, compared to control and MTA group. Conclusion: Steroid additiondecrease viability. There was an increase in 72 hours, marking cells proliferation.;Background: Calcium silicate based materials are being developed continuously,one of them is calcium silicate based cement containing steroid. Objective: Toanalyze the effect of steroid addition in calcium silicate based cement onfibroblast cells viability. Methods: Chicken embryonic fibroblast cells wereimmersed in extract solution of calcium silicate based cement containing steroidand MTA. Viability was analyzed by MTT Assay. Results: Significant difference (p ≤ 0,05) of viability on calcium silicate based cement containing steroid groupwas found, compared to control and MTA group. Conclusion: Steroid additiondecrease viability. There was an increase in 72 hours, marking cells proliferation.;Background: Calcium silicate based materials are being developed continuously,one of them is calcium silicate based cement containing steroid. Objective: Toanalyze the effect of steroid addition in calcium silicate based cement onfibroblast cells viability. Methods: Chicken embryonic fibroblast cells wereimmersed in extract solution of calcium silicate based cement containing steroidand MTA. Viability was analyzed by MTT Assay. Results: Significant difference (p ≤ 0,05) of viability on calcium silicate based cement containing steroid groupwas found, compared to control and MTA group. Conclusion: Steroid additiondecrease viability. There was an increase in 72 hours, marking cells proliferation."

"Injeksi PGE2 pada mukosa bukal bersamaan dengan tekanan ortodonti dapat mempercepat pergerakan gigi. Namun metode ini mempunyai kekurangan yaitu resorpsi tulang alveolar dan akar gigi yang besar serta rasa sakit. Gel digunakan sebagai media penghantar, menggantikan bentuk injeksi. Stabilitas PGE2 dalam gel, efek aplikasi gel PGE2 pada pergerakan gigi, konsentrasi RANKL pada GCF dan serum serta resorpsi tulang alveolar dan resorpsi akar gigi belum pernah diketahui. Penelitian ini eksperimental laboratorium in vitro untuk uji stabilitas gel PGE2 lyophillized dan in vivo pada Macaca fascicularis. Mukosa bukal kaninus kanan dioleskan gel PGE2, sedangkan kaninus kiri dioleskan gel tanpa PGE2, keduanya disertai tekanan ortodonti, pada awal, jam kedua dan keempat, selama dua menit. Pengolesan gel, pengukuran pergerakan gigi, pengambilan darah dan GCF, dilakukan setiap minggu. Macaca dieuthanasia, dinekropsi lalu dibuat sediaan histologi dan dievaluasi dengan TRAP. Gel PGE2 lyophillized tidak stabil, sehingga dibuat resenter paratus. Gel PGE2 dapat mempercepat pergerakan gigi 1,8 kali, RANKL dan resorpsi tulang alveolar lebih besar dari kontrol, serta resorpsi akar sama dengan kontrol. Gel PGE2 mempunyai prospek sebagai medikasi topikal untuk mempercepat pergerakan gigi ortodontik.

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The injection of PGE2 on buccal mucosa along with orthodontic force could accelerate orthodontic tooth movement. Nevertheless, this method also has adverse effects such as pain, over resorption of the alveolar bone and root structure. PGE2 gel to substitute the necessity of injection. Hence, the effect of PGE2 gel on the rate of tooth movement and RANKL concentration in GCF and blood serum also alveolar bone and root resorption is yet to be determined.

This study was an experimental laboratory in vitro to know the stability of PGE2 gel lyophillized and in vivo in Macaca fascicularis. PGE2 gel was applied on buccal mucosa of right canine along with orthodontic force and non- PGE2 gel on left canine on beginning, second, and fourth hour each for two minutes. Gel application, tooth movement measurement, blood sample, and GCF were done every week. Macaca euthanized, and made histology ​​ and evaluated by TRAP. PGE2 gel was made resenter paratus due to instability.

Results showed that PGE2 gel enhanced tooth movement 1.8 times, RANKL and alveolar bone resorption were greater than control and root resorption was similar to control. PGE2 gel had a good prospect as topical medication to enhance tooth movement in orthodontics."

"Latar Belakang: Ekstrak etanol temulawak (Curcuma xanthorrhiza Roxb.) telah terbukti secara in vitro memiliki khasiat sebagai anti Candida albicans (C.albicans). Dalam upaya pengembangan tanaman obat tersebut sebagai obat herbal terstandar anti C.albicans, ekstrak etanol temulawak telah diformulasikan menjadi obat tetes oromukosa. Temulawak mengandung kurkumin yang merupakan senyawa polifenolik berwarna kuning yang dapat menyebabkan diskolorasi gigi. Tujuan: Mengetahui pengaruh paparan obat tetes ekstrak etanol temulawak terhadap warna email gigi. Metode: Gigi premolar tanpa karies dan defek struktural dicelupkan dalam obat tetes ekstrak etanol temulawak, CHX 0,2%, dan akuades selama 1 menit kemudian dibilas dan direndam dalam akuades selama 10 menit pada suhu 37oC. Tahapan dilakukan sebanyak 42 siklus (simulasi penggunaan 2 minggu) dan 63 siklus (simulasi penggunaan 3 minggu). Analisis warna dilakukan menggunakan colorimeter pada 3 tahap waktu yaitu sebelum paparan, setelah paparan, dan setelah penyikatan gigi. Nilai yang didapatkan berupa ΔE yang menunjukkan selisih nilai pengukuran warna email sebelum dan setelah paparan obat serta sebelum dan setelah penyikatan. Hasil: Pada tahap waktu T1-T3 simulasi penggunaan 2 minggu dan 3 minggu, nilai ΔE>3.3 pada ketiga kelompok sehingga terlihat adanya perubahan warna yang signifikan antara warna gigi awal dan setelah penyikatan gigi. Terdapat perubahan warna gigi yang signifikan setelah dilakukan penyikatan dengan pasta gigi. Kesimpulan: Obat tetes ekstrak etanol temulawak mengakibatkan perubahan warna email gigi yang signifikan. Penyikatan gigi dapat mengurangi efek perubahan warna pada email gigi.

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Background: Javanese Turmeric (Curcuma xanthorrhiza Roxb.) ethanol extract is known to have antifungal properties against Candida albicans (C.albicans) based on in vitro studies. The next step in developing a standardised herbal medicine is by formulating Javanese Turmeric Ethanol Extract into oromucosal drops. Curcumin found in javanese turmeric is a yellowish polyphenolic compound that has the potential to cause staining on the enamel.

Objective: This study is aimed to evaluate the effect Javanese Turmeric ethanol extraxt oromucosal drops on discoloration of the dental enamel.

Method: Premolars with no caries and structural defects are immersed in the Javanese Turmeric ethanol extract oromucosal drops, a 0,2% CHX mouthwash, and distilled water for 1 minute. After rinsing, they are then immersed in distilled water for 10 minutes at 37oC. The method mentioned is repeated for 42 cycles (2-week simulation) and 63 cycles (3-week simulation). Color assessment is done using a colorimeter at three different time points: before immersion, after immersion, and after brushing. Results will be shown as ΔE which is the color difference of enamel before and after immersion, as well as before and after toothbrushing.

Result: At time point T1-T3 for the 2-week and 3-week simulation, the ΔE score is greater than 3.3 on all three groups indicating a significant color difference before immersion and after toothbrushing. A significant color difference is observed after toothbrushing with toothpaste.

Conclusion: Javanese Turmeric ethanol extract oromucosal drops cause a significant tooth discoloration. Brushing had significant effect on removal of induced stains."

"ABSTRAKPemutihan gigi sudah menjadi kebutuhan banyak orang untuk menunjangpenampilan estetika. Pada prosedur pemutihan gigi, biasanya menggunakanbahan-bahan pemutih seperti hidrogen peroksida, karbamid peroksida, dankarbopol. Namun bahan-bahan pemutih gigi tersebut dapat menimbulkan efeksamping seperti sensitifitas gigi paska tindakan serta iritasi pada rongga mulut danmukosa saluran cerna bila tertelan. Buah alpukat, apel, mangga, nanas, dan pisangadalah jenis buah yang diketahui mengandung hidrogen peroksida. Penelitian inibertujuan untuk mengetahui efek pada jus buah alpukat, apel, mangga, nanas, danpisang dalam memutihkan gigi yang mengalami diskolorisasi ekstrinsik. Gigipremolar post-ekstraksi yang telah diskolorisasi teh dan diskolorisasi kopi diberiperlakuan jus buah selama 14 hari. Hasil uji menunjukkan bahwa terjadiperubahan rata-rata skala warna pada kelompok teh dengan perlakuan jus buahalpukat, apel, mangga, nanas, dan pisang dari skala 12 menjadi rata-rata sebesar5,4 ± 0,51; 4,4 ± 1,07; 4,9 ± 1,07; 4,5 ± 0,97 dan 4,8 ± 1,13. Sedangkan padakelompok kopi dengan perlakuan jus buah alpukat, apel, mangga, nanas, danpisang dari skala 9 menjadi rata-rata sebesar 1,6 ± 0,69; 2,2 ± 1,54; 2,2 ± 1,31; 1,5± 1,84; 1,37 ± 1,06.

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ABSTRACTTeeth whitening has become a need for many people to support the aestheticappearance. In the teeth whitening procedure, usually using bleaching ingredientssuch as hydrogen peroxide, carbamide peroxide, and carbopol. However theingredients of teeth whitening can cause side effect such as tooth sensitivity andirritation after the action in the oral cavity and gastrointestinal mucosa if ingested.Avocado, apple, mango, pineapple, and bananas are the types of fruit are knownto contain hydrogen peroxide. This study aims to determine the effect on fruitjuice avocado, apple, mango, pineapple, and banana in the teeth whiteningexperience extrinsic discoloration. Post-extraction of premolars that haddiscoloration of tea and coffee discoloration of the treated fruit juice for 14 days.The test results showed that the average changes color scale on tea grouptreatment with avocado fruit juices, apple, mango, pineapple, and banana of thescale of 12 to an average of 5.4 ± 0.51; 4.4 ± 1.07; 4.9 ± 1.07; 4.5 ± 0.97 and 4.8 ±1.13. Whereas in the coffee group treated fruit juice with avocado, apple, mango,pineapple, and banana of the scale of 9 to an average of 1.6±0.69; 2.2 ± 1.54; 2.2± 1.31, 1.5 ± 1.84; 1.37 ± 1.06."

"Latar Belakang: Untuk menilai status kesehatan gigi dan mulut, selama puluhan tahun para ahli studi epidemiologi kesehatan komunitas menggunakan indeks Decayed, Missing, and Filled Teeth (DMF-T). Berdasarkan data Riset Kesehatan Dasar pada tahun 2018, rerata skor indeks DMF-T penduduk Indonesia sebesar 7,1 yang tergolong tinggi. Kehilangan gigi merupakan kondisi oral ireversibel yang dideskripsikan sebagai indikator final mengenai keparahan kondisi kesehatan gigi dan mulut. Kehilangan gigi menyebabkan kerusakan fungsional, estetika, dan sosial-psikologis serta berdampak sangat besar terhadap kualitas hidup individu. Kehilangan gigi dapat disebabkan oleh berbagai faktor. Maka dari itu, diperlukan data mengenai pengaruh berbagai faktor risiko terhadap kehilangan gigi pada berbagai kelompok usia.Tujuan: Memperoleh data hubungan faktor risiko dan rerata jumlah kehilangan gigi pada subjek usia 31-75 tahun dari radiograf panoramik digital. Metode: Penelitian ini menggunakan data sekunder berupa 375 sampel radiograf panoramik digital subjek usia 31-75 tahun di Rumah Sakit Khusus Gigi dan Mulut Fakultas Kedokteran Gigi Universitas Indoneisa (RSKGM FKGUI). Subjek dibagi menjadi 3. kategori: 31-45 tahun, 46-60 tahun, dan 61-75 tahun. Untuk mendapatkan jumlah kehilangan gigi dan data mengenai faktor risiko umur, jenis kelamin, karies/jumlah restorasi/lesi periapikal, dan kehilangan tulang/penyakit periodontal, dilakukan interpretasi radiograf panoramik digital. Kemudian dilakukan uji reliabilitas intraobserver dan interobserver dengan t-test dan Bland Altman. Hasil: Median, nilai minimum, dan nilai maksimum jumlah kehilangan gigi pada kelompok usia 31-45 tahun sejumlah 1 (0-5) gigi, usia 46-60 tahun sejumlah 5 (0-19) gigi, dan usia 61-75 tahun sejumlah 10 (2-28) gigi. Jumlah kehilangan gigi antar kelompok usia berbeda bermakna (p<0.05 berdasarkan uji Kruskal Wallis). Jumlah kehilangan gigi bertambah seiring penuaan usia. Analisis korelasi faktor-faktor risiko terhadap kehilangan gigi menunjukkan bahwa usia dan status periodontal berhubungan sangat kuat dengan kehilangan gigi, jumlah karies gigi dan lesi periapikal memiliki hubungan sedang dengan kehilangan gigi, dan jenis kelamin dan jumlah restorasi gigi memiliki hubungan lemah dengan kehilangan gigi. Kesimpulan: Jumlah kehilangan gigi pada usia 31-45 tahun berbeda bermakna dibandingkan pada usia 46-60 dan 61-75 tahun. Kehilangan gigi cenderung bertambah seiring penuaan usia. Faktor risiko yang hubungannya sangat kuat dengan kehilangan gigi adalah usia dan kehilangan tulang.

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Background: To assess community oral health status, for several decades, epidemiologists have always used Decayed, Missing, and Filled Teeth (DMF-T) index. Based on the 2018 Basic Health Research, the mean of DMF-T index of Indonesia’s population was 7.1, which was considered high. Tooth loss is an irreversible oral condition that is often described as the final indicator of oral health status that causes functional, aesthetics, and social-psychological damage that greatly affects life quality. Tooth loss is a multi-factorial phenomenon. Thus, a concrete data is needed to assess the impact of risk factors on tooth loss in several age categories.

Objective: To obtain the data of tooth loss risk factors and the mean of missing teeth in 31-75-year-old subjects from digital panoramic radiograph.

Methods: This study was completed using secondary data of 375 digital panoramic radiographs in Universitas Indonesia Dental Hospital (RSKGM FKGUI). The subjects were devided into 3 categories: 31-45 years old, 46-60 years old, and 61-75 years old. In order to obtain the data of tooth loss and its risk factors: age, gender, caries/restoration/periapical disease, and periodontitis, the digital panoramic radiographs were interpreted. Then, the reliability test for both intraobserver and interobserver were conducted using t-test and Bland Altman test.

Results: The median, minimum, and maximum of tooth loss in the 31-45 years old group is 1 (0-5) teeth, 46-60 years old group is 5 (0-19) teeth, and 61-75 years old group is 10 (2-28) teeth. The number of tooth loss in all age groups are statistically different (p<0.05 in Kruskal Wallis test). The number of tooth loss increases as aging continues. Correlation analysis of the tooth loss risk factors showed that age and periodontitis have a very strong correlation with tooth loss, the number of tooth caries and periapical disease have a moderate correlation with tooth loss, and gender and restoration have a weak correlation with tooth loss.

Conclusion: The number tooth loss occurred in 31-45 years old group subject is significantly different compared to the number of tooth loss in 46-60 and 61-75 years old group. Tooth loss is strongly correlated with age and bone loss."