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Acil Aryadi
Perbandingan efektifitas antara lisinopril dan amlodipin terhadap penurunan tekanan darah pada pasien hipertensi ras melanesia = Effectiveness comparison between lisinopril and amlodipine in melanesian patients with hypertension
"Latar Belakang : Keberhasilan pengobatan antihipertensi dipengaruhi banyak hal, salah satunya adalah faktor genetik, termasuk perbedaan ras dan aktivitas renin plasma (ARP). Perbedaan ras, berkaitan dengan ARP, mungkin dapat memberikan perbedaan respon terhadap obat antihipertensi. Aktivitas renan plasma dan perbandingan efektifitas obat antihipertensi (lisinopril dan amlodipin) pada ras melanesia di Provinsi Papua belum pernah diteliti.
Tujuan : Mengukur aktivitas renin plasma dan membandingkan efektifitas obat lisinopril dan amlodipin pada pasien hipertensi ras melanesia untuk menurunkan tekanan darah.
Metode : Pada awal penelitian, 68 subjek berhasil direkrut, dilakukan randomisasi dan dibagi ke dalam dua kelompok. Sebanyak 34 subjek mendapat lisinopril 5 mg dan 34 subjek mendapat amlodipine 2.5 mg. Tekanan darah, ARP dan karakteristik dasar lainnya diukur sebelum intervensi, dan kemudian di follow up tiap minggu. Subjek yang belum mencapai target tekanan darah akan diberikan peningkatan dosis obat, lisinopril 10 hingga 20 mg dan amlodipin 5 hingga 10 mg. Pada akhir penelitian (minggu keempat), tekanan darah diukur sebagai luaran klinis. Sebanyak 7 subjek drop out, 4 subjek pada kelompok lisinopril dan 3 subjek pada kelompok amlodipin.
Hasil : Aktivitas renin plasma pada populasi penelitian ini 1.6 ng/ml/jam (normal). Karakteristik dasar klinis tidak berbeda antara kedua kelompok, termasuk rerata tekanan darah sebelum intervensi dan ARP. Pada kedua kelompok didapatkan penurunan tekanan darah yang signifikan setelah intervensi, baik pada tekanan darah sistolik (TDS), distolik (TDD) dan tekanan nadi (TN). Namun, pada penelitian ini, perbedaan respon penurunan tekanan darah antara kelompok lisinopril dan amlodipin tidak berbeda (TDS 24.6 ± 9.3 vs 25.9 ± 8.9 mmHg, p=0.56; TDD 13.3 ± 5.5 vs 11.4 ± 4.8 mmHg, p=0.15; TN 17.1 ± 5.6 vs 16.3 ± 5.0 mmHg, p=0.55).
Kesimpulan : Aktivitas renin plasma pada pasien hipertensi ras melanesia normal dan pemberian lisinopril tidak menunjukkan perbedaan penurunan respon penurunan tekanan darah dibandingkan dengan amlodipin.
Background: The success of antihypertensive treatment are influenced by many factors, one of which are genetic factors, including differences in race and plasma renin activity (PRA). Racial differences, regarding PRA, may give different response to antihypertensive drugs. Plasma renin activity and comparison of the effectiveness of antihypertensive medications (lisinopril and amlodipine) in the Melanesian race in the province of Papua have not been investigated.
Objectives: To measure plasma renin activity and compare the effectiveness of lisinopril and amlodipine in melanesian hypertensive patients to reduce blood pressure.
Methods: Sixty eight subjects were randomly assigned into 2 groups, those receiving lisinopril 5 mg (34 subjects) and amlodipine 2.5 mg (34 subjects). Blood pressure, PRA and other baseline characteristics were measured before the intervention, and then evaluated every week. Dose of lisinopril and amlodipine will be increased in subjects who have not achieved blood pressure target, 10 mg to 20 mg and 5 mg to 10 mg, respectively. At the end of the fourth week, blood pressure is measured as the main clinical outcome. Seven subjects were drop out, four from lisinopril group and three from amlodipin group.
Results: Plasma renin activity in this study population was 1.6 ng/ml/h (normal). Baseline characteristics did not differ between two groups, including blood pressure and PRA before intervention. Significant decrease in blood pressure occurred in both group after the intervention, including systolic blood pressure (SBP) , diastolic (DBP) and mean arterial pressure (MAP). However, there are no differences in blood pressure reduction between lisinopril and amlodipine groups. (SBP 24.6 ± 9.3 vs 25.9 ± 8.9 mmHg, p=0.56; DBP 13.3 ± 5.5 vs 11.4 ± 4.8 mmHg, p=0.15; MAP 17.1 ± 5.6 vs 16.3 ± 5.0 mmHg, p=0.55).
Conclusion: Plasma renin activity in melanesian hypertensive patients was normal and administration of lisinopril showed no difference in blood pressure reduction compared with amlodipine."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Ayuthia Putri Sedyawan
Perbandingan efek lisinopril dan amlodipin terhadap kekakuan pembuluh arteri pada pasien hipertensi yang belum pernah diobati = aortic stiffness in native hypertension amlodipin versus lisinopril administration ashalina study
"[ABSTRAK
Latar belakang. Hipertensi adalah faktor risiko kardiovaskular yang penting. Kekakuan arteri meningkat seiring dengan peningkatan usia, hipertensi, diabetes mellitus, aterosklerosis, dan lainnya. Kekakuan arteri dapat diukur secara non-invasif dengan menggunakan alat carotid-femoral pulse wave velocity (CF-PWV), dimana alat ini mengukur kecepatan gelombang nadi yang berjalan dari arteri karotis komunis ke arteri femoralis. Obat antihipertensi telah diketahui memiliki kemampuan terhadap kekakuan arteri, namun berbeda efektifitasnya.
Tujuan. Melihat perbandingan efek pemberian penghambat enzim pengubah angiotensin dan penyekat kanal kalsium terhadap kekakuan arteri pada pasien hipertensi yang belum pernah diobati sebelumnya.
Metode. Uji klinis acak dengan tersamar ganda, dilakukan di RS Pusat Jantung dan Pembuluh Darah Harapan Kita (Maret-Mei 2015) terhadap 54 subyek usia 30-50 tahun. Subyek dibagi menjadi dua grup, grup lisinopril (n=27) dan amlodipin (n=27). Tekanan darah dan CF-PWV diukur sebelum dan setelah intervensi.
Hasil. Terdapat penurunan tekanan darah dan sesudah terapi untuk kedua grup. Delta penurunan CF-PWV untuk kedua intervensi menujukkan hasil yang signifikan (P value <0.001). Lisinopril memiliki penurunan delta CF-PWV yang lebih signifikan dibandingkan amlodipin. (P value <0.001 IK 95% 0.2 - 0.5).
Kesimpulan. Penelitian ini membuktikan adanya perbedaan bermakna terhadap CF-PWV pada grup yang diberikan lisinopril dan amlodipin, dimana lisinopril memiliki delta penurunan PWV yang lebih signifikan.
ABSTRACT
Background. Hypertension is a well-recognized cardiovascular risk factors. Arterial stiffness increases with age, hypertension, diabetes mellitus, atherosclerosis, etc. Arterial stiffness can be assessed noninvasively by carotid-femoral pulse wave velocity (CF-PWV) measurement, that is, the velocity of the pulse wave to travel a given distance between carotid and femoral artery. Antihypertensive drugs have been implicated in arterial stiffness diminishment but vary in effectiveness.
Objective. To examine the difference in arterial stiffness reduction in young native hypertensive subjects that was given ace-inhibitor or calcium channel blocker.
Methods. A double blind randomized clinical trial was conducted in National Cardiovascular Centre Harapan Kita to 54 subjects (30-50 years old), from March to May 2015. Subjects were divided into lisinopril 5mg (n=27) and amlodipine 5mg (n=27) groups. Blood pressure and CF-PWV were measured before and 4 weeks post therapy.
Results. Blood pressure reduction was found before and after treatment for both groups. CF-PWV for lisinopril and amlodipine showed significant reduction (p-value <0.001). Lisinopril had more significant decrease in CF-PWV (P value <0.001 CI 95% 0.2 - 0.5).
Conclusion. There was a statistically significant difference in CF-PWV reduction between lisinopril and amlodipin administration to patients with native hypertension, with lisinopril having the larger effect., Background. Hypertension is a well-recognized cardiovascular risk factors.
Arterial stiffness increases with age
subjects with diabetes mellitus,
and hypertension
and is also enhanced in
atherosclerosis,
and end-stage renal disease.
Arterial stiffness can be assessed noninvasively with the use of carotid-femoral
pulse wave velocity (CF-PWV) measurement, that is, the velocity of the pulse
wave to travel a given distance between carotid and femoral artery.
Antihypertensive drugs have been implicated in arterial stiffness diminishment
but vary in their degree of effect. The calcium channel blocker having its
“destiffening” effect have been widely known to reduce arterial stiffness.
However, the renin-angiotensin system inhibitors proved to be superior to all
other antihypertensive drugs in reducing arterial stiffness.
Objective. The aim of this study was to examine the difference in arterial stiffness
reduction in native hypertensive subjects that was given ace-inhibitor or calcium
channel blocker for four weeks, by measuring the CF-PWV.
Methods. A double blind randomized clinical trial was conducted in National
Cardiovascular Centre Harapan Kita (NCCHK) to 54 subjects with native
hypertension between the age of 30-50 years old, from March to May 2015.
Subjects were divided into two groups: lisinopril 5mg (n=27) and amlodipine 5mg
(n=27). Blood pressure and CF-PWV were measured before and after 4 weeks of
therapy. Statistical analysis was done using bivariat and multivariat analisis to
determine the significance of arterial stiffness reduction.
Results. There was a reduction in blood pressure (systole, diastole, mean arterial
pressure) before and after the treatment for both groups. However although it was
clinicaly significant, statistically it was not (P value >0.05). Nonetheless, CFPWV
for
lisinopril
and
amlodipin
showed
significant
reduction
with
both
p-value
were
<0.001 (2.09±0.280, CI 95% 1.80-2.2 and 1.77±0.340, CI 95% 1.6-1.9).
When both drugs were compared using multivariate analysis, lisinopril was
proved to have a more significant decrease in CF-PWV (P value <0.001 CI 95%
0.2 - 0.5).
Conclusion. This study proved that there was a statistically significant difference
in CF-PWV reduction between lisinopril and amlodipin administration to patients with native hypertension, with lisinopril having the larger effect. ]"
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Yusak Alfrets Porotuo
Respon tekanan darah pasien hipertensi ras Melanesia dan ras non Melanesia dengan pemberian penyekat enzim angiotensin = Blood pressure response in hypertensive patients Melanesian race and non Melanesian race with angiotensin converting enzyme inhibitors
"ABSTRAK
Latar belakang. Hipertensi merupakan salah satu kondisi yang paling banyak
ditemukan pada pelayanan kesehatan primer yang dapat meningkatkan mortalitas dan
morbidita apabila tidak mendapatkan pengobatan yang tepat. Beberapa penelitian
menunjukkan respon penurunan tekanandarah pada ras kulit hitam berbeda dibanding
ras kulit putih dengan antihipertensi golongan penyekat EKA, hal ini ditunjang
dengan perbedaan PRA pada kedua kelompok ras ini. Belum terdapat data tentang
respon tekanan darah pasien hipertensi ras melanesiadengan pemberian penyekat
EKA yang ditunjang dengan pemeriksaan kadar PRA pada kelompok ras ini.
Objektif. Menilai apakah terdapat perbedaan respon terapi terhadap penyekat enzim
konversi angiotensin (EKA) pada pasien hipertensi ras melanesia dan ras non
melanesia.
Metode. Penelitian ini adalah penelitian kohort prospektif yangdilakukan di kota
Jayapura bulan September-November 2015terhadap 85 subyek usia 30 sampai 55
tahun dengan hipertensi yang belum pernah diobati sebelumnya. Subyek terbagi atas
2 grup yaitu ras Melanesia (n=34) dan ras Non Melanesia(n=51). Kedua grup tersebut
diberikan lisinopril dosis awal 5 mg. Pemeriksaan tekanan darah dilakukan pada awal
dan diulangi setiap 7 hari selama 4 minggu berturut-turut.
Hasil. Terdapat perbedaan respon tekanan darah pasien hipertensi ras Melanesia dan
ras Non Melanesia. Perbedaan tekanan darah sistolik sebesar 24,5 ± 9,4 mmHg pada
subyek ras Melanesia dan pada subyek Non Melanesia sebesar 34,5 ± 13,5 mmHg
(p<0,001). Perbedaan tekanan darah diastolik subyek ras Melanesia sebesar 13,3±5,5
mmHg dan pada subyek Non Melanesia sebesar 22,6±9,3 mmHg (p<0,001).
Perbedaan tekanan rerata arteri pada subyek ras Melanesia sebesar 17,1±5,6 mmHg
dan pada subek ras Non Melanesia sebesar 26,21±8,8 mmHg (p<0,001). Reratakadar
Plasma Renin Activity (PRA) pada subyek ras Melanesia sebesar 1,48[1,86]
ng/ml/jam dan pada subyek ras Non Melanesia rerata kadar PRA sebesar 1,1[1,47]
ng/ml/jam. Tidak terdapat hubungan yang bermakna rerata kadar PRA pada kedua
kelompok ras ini (p=0,564).
Kesimpulan. Terdapat perbedaan penurunan tekanan darah (sistolik, diastolik dan
tekanan rerata arteri) dengan pemberian penyekat EKA pada kelompok ras Melanesia
dan kelompok ras Non Melanesia dan hal ini tidak berhubungan bermakna dengan
rerata kadar PRA pada kedua kelompok ini sehingga kemungkinan terdapat faktor lain yang mempengaruhi respon penurunan tekanan darah dengan penyekat EKA.ABSTRACT
Hypertension is one of the most commonconditionsin primary health
care that increase mortality and morbidity if it does not receive appropriate therapy.
Several studies show that blacks response differently compared with white in
conjunction with a decrease of blood pressure in response to administer ACE
inhibitor. The studies supported by PRA differences in both group of race. There are
no data ofblood pressure response in hypertensive patientsinMelanesian race by
administeringACE inhibitor supported withPRA levels examination in thisgroup of
race.
Objective. To compare therapeutic response ofangiotensin converting enzyme
blockers (ACE)inhibitorinreducing blood pressure between MelanesianandNon
Melanesian hipertensive patients.
Method. This study is a prospective cohort study conducted in the city of
Jayapura September to November 2015. We found85 subjects aged 30 to 55 years
oldwith hypertensionnever be treated before. Subjects are divided into two
groups, namely the Melanesian race (n = 34) and non Melanesian race (n = 51).
Both groups were given an initial dose of 5 mg of lisinopril. Blood pressure
checks performed at baseline and repeated every 7 days for 4 weeks in a row.
Results. There are differences in the response of blood pressure in hypertensive
patientofMelanesian race and Non Melanesiarace. Reduction ofsystolic blood
pressure of 24.5 ± 9.4 mmHg in subject Melanesian race and on the subject of
Non Melanesian 34.5 ± 13.5 mmHg (p < 0.001). Reduction ofdiastolic blood
pressure of subjectsMelanesians of 13.3 ± 5.5 mmHg, and on the subject of Non
Melanesia 22.6 ± 9.3 mmHg (p<0.001). Reduction ofmean arterial pressure in
subjectMelanesian race at 17.1 ± 5.6 mmHg andNon Melanesian race at 26.21 ±
8.8 mmHg (p < 0.001). Mean Plasma Renin Activity (PRA) on the subject of the
Melanesian race at 1.48 [1.86] ng/ml/h and on the subject of nonMelanesian race
PRA average level of 1.1 [1.47] ng/ml/hr. There was no significant relationship
mean PRA levels in both these racial groups (p = 0.564).
Conclusion. There aredifferences in blood pressure reduction (systolic, diastolic
pressure and mean arterial pressure) with administer of ACE inhibitor in
Melanesianand Non Melanesiagroup of race. There is no significant relation with
averagePRAlevels in both group of race. Another factors affectsresponses of reduction blood pressure with administer ofACEinhibitor may be considered.;Background. Hypertension is one of the most commonconditionsin primary health
care that increase mortality and morbidity if it does not receive appropriate therapy.
Several studies show that blacks response differently compared with white in
conjunction with a decrease of blood pressure in response to administer ACE
inhibitor. The studies supported by PRA differences in both group of race. There are
no data ofblood pressure response in hypertensive patientsinMelanesian race by
administeringACE inhibitor supported withPRA levels examination in thisgroup of
race.
Objective. To compare therapeutic response ofangiotensin converting enzyme
blockers (ACE)inhibitorinreducing blood pressure between MelanesianandNon
Melanesian hipertensive patients.
Method. This study is a prospective cohort study conducted in the city of
Jayapura September to November 2015. We found85 subjects aged 30 to 55 years
oldwith hypertensionnever be treated before. Subjects are divided into two
groups, namely the Melanesian race (n = 34) and non Melanesian race (n = 51).
Both groups were given an initial dose of 5 mg of lisinopril. Blood pressure
checks performed at baseline and repeated every 7 days for 4 weeks in a row.
Results. There are differences in the response of blood pressure in hypertensive
patientofMelanesian race and Non Melanesiarace. Reduction ofsystolic blood
pressure of 24.5 ± 9.4 mmHg in subject Melanesian race and on the subject of
Non Melanesian 34.5 ± 13.5 mmHg (p < 0.001). Reduction ofdiastolic blood
pressure of subjectsMelanesians of 13.3 ± 5.5 mmHg, and on the subject of Non
Melanesia 22.6 ± 9.3 mmHg (p<0.001). Reduction ofmean arterial pressure in
subjectMelanesian race at 17.1 ± 5.6 mmHg andNon Melanesian race at 26.21 ±
8.8 mmHg (p < 0.001). Mean Plasma Renin Activity (PRA) on the subject of the
Melanesian race at 1.48 [1.86] ng/ml/h and on the subject of nonMelanesian race
PRA average level of 1.1 [1.47] ng/ml/hr. There was no significant relationship
mean PRA levels in both these racial groups (p = 0.564).
Conclusion. There aredifferences in blood pressure reduction (systolic, diastolic
pressure and mean arterial pressure) with administer of ACE inhibitor in
Melanesianand Non Melanesiagroup of race. There is no significant relation with
averagePRAlevels in both group of race. Another factors affectsresponses of reduction blood pressure with administer ofACEinhibitor may be considered.;Background. Hypertension is one of the most commonconditionsin primary health
care that increase mortality and morbidity if it does not receive appropriate therapy.
Several studies show that blacks response differently compared with white in
conjunction with a decrease of blood pressure in response to administer ACE
inhibitor. The studies supported by PRA differences in both group of race. There are
no data ofblood pressure response in hypertensive patientsinMelanesian race by
administeringACE inhibitor supported withPRA levels examination in thisgroup of
race.
Objective. To compare therapeutic response ofangiotensin converting enzyme
blockers (ACE)inhibitorinreducing blood pressure between MelanesianandNon
Melanesian hipertensive patients.
Method. This study is a prospective cohort study conducted in the city of
Jayapura September to November 2015. We found85 subjects aged 30 to 55 years
oldwith hypertensionnever be treated before. Subjects are divided into two
groups, namely the Melanesian race (n = 34) and non Melanesian race (n = 51).
Both groups were given an initial dose of 5 mg of lisinopril. Blood pressure
checks performed at baseline and repeated every 7 days for 4 weeks in a row.
Results. There are differences in the response of blood pressure in hypertensive
patientofMelanesian race and Non Melanesiarace. Reduction ofsystolic blood
pressure of 24.5 ± 9.4 mmHg in subject Melanesian race and on the subject of
Non Melanesian 34.5 ± 13.5 mmHg (p < 0.001). Reduction ofdiastolic blood
pressure of subjectsMelanesians of 13.3 ± 5.5 mmHg, and on the subject of Non
Melanesia 22.6 ± 9.3 mmHg (p<0.001). Reduction ofmean arterial pressure in
subjectMelanesian race at 17.1 ± 5.6 mmHg andNon Melanesian race at 26.21 ±
8.8 mmHg (p < 0.001). Mean Plasma Renin Activity (PRA) on the subject of the
Melanesian race at 1.48 [1.86] ng/ml/h and on the subject of nonMelanesian race
PRA average level of 1.1 [1.47] ng/ml/hr. There was no significant relationship
mean PRA levels in both these racial groups (p = 0.564).
Conclusion. There aredifferences in blood pressure reduction (systolic, diastolic
pressure and mean arterial pressure) with administer of ACE inhibitor in
Melanesianand Non Melanesiagroup of race. There is no significant relation with
averagePRAlevels in both group of race. Another factors affectsresponses of reduction blood pressure with administer ofACEinhibitor may be considered."
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Makalah dan Kertas Kerja  Universitas Indonesia Library
cover
Pius A.L. Berek
Efektifitas slow deep breathing terhadap penurunan tekanan darah pada pasien hipertensi primer di Atambua Nusa Tenggara Timur : a randomized controlled trial = Effectiveness of slow deep breathing on decreasing blood pressure in primary hypertension patients at Atambua East Nusa Tenggara : a randomized controlled trial
"Slow deep breathing (SDB) adalah tindakan nonfarmakologis untuk menurunkan tekanan darah pasien hipertensi primer. Penelitian ini bertujuan untuk mengetahui efektifitas SDB terhadap penurunan tekanan darah pasien hipertensi primer. Metode penelitian ini menggunakan desain Randomized Clinical Trial dengan pretest dan post test control group. Sampelnya 142 responden, meliputi 33 responden kelompok rendah garam (RG), 37 responden kelompok SDB, 39 responden kombinasi kelompok SDB dan RG; dan 33 responden kelompok kontrol. Sampel diambil dengan cara randomisasi.
Hasil penelitian menunjukan penurunan tekanan darah secara bermakna terutama pada kelompok SDB. Tekanan darah sistolik menurun 28,59 mmHg (P value=0,002) dan tekanan darah diastolik 16,92 mmHg (P value=0,007). Analisis dengan uji Tukey diketahui tekanan darah sistolik yang berbeda secara bermakna yaitu antara SDB dan kelompok kontrol (P value=0,001). Tekanan darah diastolik yang berbeda secara bermakna, yaitu: RG dan SDB-RG (P value=0,046); RG dan kelompok kontrol (P value=0,003); SDB dan SDB-RG (P value=0,038) serta SDB dan kelompok kontrol (P value=0,005). Penelitian ini merekomendasikan penerapan SDB untuk membantu menurunkan prevalensi hipertensi sehingga meminimalkan komplikasi yang mungkin timbul.
Slow deep breathing is a nonpharmacology therapy to reduce blood pressure in patients with primary hypertension. The purpose of this study was to determine the effectiveness of slow deep breathing exercise to reduce blood pressure in patients with primary hypertension in Atambua East Nusa Tenggara. The method of this research was a quantitative research: a randomized clinical trial design with pretest and post test control group. The sample was 142 respondents, which consisted of 33 respondents in the lower salt (RG) group, 37 respondents in the slow deep breathing (SDB) group, 39 respondents in the combination of SDB-RG group; and 33 respondents in the control group. The method of sampling used a randomization.
The results showed that there were differences in the reduction of systolic blood pressure in SDB group for 28.59 mm Hg and diastolic blood pressure for 16.92 mmHg. The result of Anova analysis showed that there was a significant decrease on average of systolic blood pressure (p = 0.002) and diastolic blood pressure (p = 0.007). Further analysis by Tuckey test of systolic blood pressure found that between SDB group and control group were significantly different, however the other groups was not significant. (P = 0.001). After undergoing further Tukey analysis we found that the systolic blood pressure of four groups has significant differences. The SDB and controlling groups have P value=0,001 differences. RG and the controlling groups have P value=0,003 differences. SDB and SDB-RG groups have P value=0,038 differences. And SDB and controlling groups have P value=0,005 differences. This research would like to suggest applied non-pharmacological actions particularly toward SDB groups in order to decrease the prevalence of hypertension. This will minimize consequences caused by this problem."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2010
T29384
UI - Tesis Open  Universitas Indonesia Library
cover
Abdul Hakim
Pengaruh pemberian Metformin terhadap Variabilitas tekanan darah pada subyek Hipertensi dengan Prediabetes yang Mendapat Lisinopril = The Effect of Metformin Administration on Blood Pressure Variability in Hypertensive Subjects with Prediabetes Receiving Lisinopril
"Latar belakang: Hipertensi dan prediabetes adalah komponen mayor sindroma metabolik dan juga faktor risiko penyakit kardiovaskular. Variabilitas tekanan darah menjadi salah satu faktor untuk penyakit kardiovaskular, beberapa data menunjukan peningkatan variabilitas tekanan darah berhubungan dengan meningkatnya kejadian stroke, penyakit jantung koroner, dan semua penyebab kematian. Variabilitas tekanan darah pada populasi prediabetes memiliki variabilitas yang lebih tinggi dibandingkan populasi normal.
Tujuan: Mengetahui efek pemberian metformin pada lisinopril selain sebagai obat oral antidiabetes memiliki efek antihipertensi dan pengaruh terhadap variabilitas tekanan darah pada populasi hipertensi dan prediabetes.
Metode: Penelitian ini merupakan uji klinis acak yang dilakukan di Rumah Sakit Jantung dan Pembuluh Darah Harapan Kita (RSJPDHK) pada karyawan yang hipertensi dengan prediabetes. Dibagi 2 kelompok yang mendapat Lisinopril 5 mg (terbuka) dan Metformin 2 x 500 mg (tersamar) atau plasebo selama 8 minggu. Dilakukan pemeriksaaan Home Blood Pressure Monitoring (HBPM) sebelum dan setelah terapi diberikan.
Hasil: Total terdapat 64 pasien menyelesaikan penelitian (31 kelompok plasebo, 33 kelompok metformin). Setelah 8 minggu follow up, variabilitas tekanan darah kelompok metformin memiliki variabilitas tekanan darah yang lebih rendah (3,8 ± 2,2 mmHg, p 0,03) dibandingkan kelompok plasebo. Perubahan rerata mean tekanan darah sistolik dan diastolik pagi kelompok metformin mengalami penurunan signifikan (p < 0,05 )
Kesimpulan: Penambahan metformin pada Subyek hipertensi dengan prediabetes yang mendapat lisinopril mengalami penurunan variabilitas tekanan darah pagi dan rerata tekanan darah pagi yang bermakna secara statistik.
Background: Hypertension and prediabetes are major components of metabolic syndrome and also risk factors for cardiovascular disease. Variability of blood pressure is one factor for cardiovascular disease, some data show an increase in blood pressure variability associated with increased incidence of stroke, coronary heart disease, and all causes of death. Blood pressure variability in the prediabetes population has a higher variability than the normal population.
Objective: To determine the effect of adding metformin to lisinopril as well as an oral antidiabetic drug that has antihypertensive effects and influence on blood pressure variability in the hypertensive population and prediabetes.
Method: This study was a randomized clinical trial conducted at National Cardiac Center Harapan Kita Hospital (NCCHK) in hypertensive employees with prediabetes. Divided into 2 groups that received Lisinopril 5 mg (open) and Metformin 2x500 mg (disguised) or placebo for 8 weeks. Examination of Home Blood Pressure Monitoring (HBPM) is carried out before and after therapy is given.
Results: A total of 64 patients completed the study (31 placebo groups, 33 metformin groups). After 8 weeks of follow-up, the blood pressure variability of the metformin group had lower blood pressure variability (3.8±2.2 mmHg, p=0.03) than in the placebo group. The mean change in mean systolic and diastolic blood pressure in the metformin group decreased significantly (p<0.05)
Conclusion: Addition of metformin to hypertensive subjects with prediabetes who received lisinopril decreased morning blood pressure variability and morning mean blood pressure which was statistically significant."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
cover
Agus Setiawan
Penurunan Ansietas Dan Tekanan Darah Melalui Pranic Healing Pada Pasien Hipertensi = Reduction Of Anxiety And Blood Pressure Through Pranic Healing In Hypertension Patients
"Latar belakang :Hipertensi merupakan salah satu penyakit yang banyak diderita yang memiliki komplikasi yang berbahaya. Dampak ansietas pada hipertensi tidak tertangani maka dapat memperburuk kondisi hipertensi. Tujuan: Penelitian bertujuan mengetahui pengaruh pranic healing terhadap ansietas, tekanan darah dan nadi pasien hipertensi. Metode: Penelitian ini quasi eksperiment pretest-postest control group dengan simple random sampling. Berdasarkan data kunjungan ke puskesmas di acak kedalam kelompok pranic healing dan kelompok kontrol. Kelompok pranic healing 37 diberikan perlakuaan pranic healing setiap pekan selama 4 pekan. Kelompok kontrol 36 diberi tindakan dasar setiap pekan selama 4 pekan. Ansietas diukur menggunakan Hamilton Anxiety Rating Scale (HARS). Analisis data menggunakan menggunakan Mann Whitney dan Independen T test. Hasil: perbedaan perubahan skor sesudah perlakuan pada kelompok intervensi dan kelompok kontrol. Pada ansietas kelompok intervensi sebesar 10 dan pada kelompok kontrol 14, dengan p = 0,001. Tekanan sistolik kelompok intervensi rerata 138,6 mmHg dan kelompok kontrol 146,0 mmHg dengan p = 0,001. Tekanan diastolik kelompok intervensi sebesar 84 mmHg dan pada kelompok kontrol 88,5 mmHg, dengan p = 0,001. Nadi kelompok intervensi sebesar 86 x/mnt dan pada kelompok kontrol 87,5 x/mnt, dengan p = 0,117. Kesimpulan: pranic healing menurunkan ansietas dan tekanan sistolik dan diastolik, pranic healing dapat digunakan pada penderita hipertensi
Background: Hypertension is one of the most common diseases that has dangerous complications. The impact of anxiety in hypertension is not handled, it can worsen the condition of hypertension. Objective: The study aims to determine the effect of pranic healing on anxiety, blood pressure, and pulse of hypertensive patients. Methods: This research is a quasi-experiment pretest-postest control group with simple random sampling. Based on data on visits to the health center, patients were randomized into a pranic healing group and a control group. The pranic healing group 37 was given pranic healing treatment every week for 4 weeks. The control group 36 was given basic care every week for 4 weeks. Anxiety was measured using the Hamilton Anxiety Rating Scale (HARS). Data analysis using Mann Whitney and Independent T-test. Results: differences in changes in scores after treatment in the intervention group and control group. In the intervention group anxiety was 10 and in the control group 14, with p = 0.001. The systolic pressure of the intervention group averaged 138.6 mmHg and the control group 146.0 mmHg with p = 0.001. The diastolic pressure of the intervention group was 84 mmHg and in the control group 88.5 mmHg, with p = 0.001. The pulse rate of the intervention group was 86 x/min and that of the control group was 87.5 x/min, with p = 0.117. Conclusion: Pranic healing reduces anxiety and systolic and diastolic pressure, pranic healing can be used in patients with hypertension."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2024
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UI - Tesis Membership  Universitas Indonesia Library
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Nyimas Rodiah
Perbandingan efek akupunktur telinga dengan akupunktur tubuh terhadap tekanan darah dan kadar nitrit oksida pada pasien hipertensi esensial di Puskesmas Kecamatan Jatinegara = The comparison of effects among ear acupuncture and body acupuncture on blood pressure and nitric oxide level in patients with essential hypertension at Puskesmas Kecamatan Jatinegara
"Umumnya penelitian akupunktur pada hipertensi menggunakan kombinasi akupunktur tubuh dan telinga yang dibandingkan dengan obat atau plasebopunktur dan belum ada yang membandingkan efektivitas antara akupunktur tubuh dengan akupunktur telinga. Selain itu di Indonesia belum ada yang meneliti efek akupunktur terhadap kadar nitrit oksida (NO) serum pada penderita hipertensi esensial.
Penelitian ini bertujuan untuk mengetahui perbandingan efek antara akupunktur telinga dengan akupunktur tubuh terhadap tekanan darah (TD) serta apakah penusukan titik akupunktur tubuh dan akupunktur telinga memiliki efek meningkatkan kadar NO serum pada penderita hipertensi esensial.
Metode penelitian yang digunakan adalah uji klinis acak terkontrol. Penelitian dilakukan pada 32 pasien hipertensi esensial yang dibagi menjadi dua kelompok yaitu kelompok A (akupunktur telinga) dan kelompok B (akupunktur tubuh).
Hasil menunjukkan rerata penurunan TD sistolik dan diastolik serta kadar NO serum antara kedua kelompok tidak berbeda bermakna (p=0.916; p=0.592; p=0.576). Dengan demikian akupunktur telinga dan akupunktur tubuh memiliki efek yang sebanding dalam menurunkan TD pada pasien hipertensi esensial meskipun hal tersebut tidak diikuti dengan peningkatan kadar NO serum.
Generally the study of acupuncture on hypertension using a combination of the body and ear acupuncture compared with medication or placebopuncture. The study comparing of efficacy body acupuncture with ear acupuncture not performed yet. In Indonesia no one has studied the effects of acupuncture on levels of nitric oxide (NO) serum in patients with essential hypertension.
This study aims to determine the comparative effects of ear acupuncture with body acupuncture on blood pressure (BP) thus whether the insertion of the acupuncture points of the body acupuncture and ear acupuncture has the effect of increasing levels of serum NO in patients with essential hypertension.
On this study used randomized clinical trial method. The research was conducted on 32 patients with essential hypertension and divided into two groups which are group A (ear acupuncture) and group B (body acupuncture).
From the results show that there were no significant differences between the ear acupuncture with body acupuncture on reducing systolic and diastolic BP and serum NO levels (p=0.916; p=0.592; p=0.576). Thus ear acupuncture and body acupuncture have the same effect in lowering blood pressure in patients with essential hypertension although this effect was not accompanied by increased levels of serum NO."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2012
T58488
UI - Tesis Membership  Universitas Indonesia Library
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Suhana
Pengaruh penanaman benang catgut terhadap kadar nitrit oksida dan tekanan darah pada pasien hipertensi esensial = The influence of catgut embedding on the nitric oxide concentration and blood pressure in essential hypertension patients
"Hipertensi sering dijumpai dalam praktek sehari-hari dan prevalensinya di Indonesia cukup tinggi (31,7%). Penanaman benang catgut terbukti menurunkan tekanan darah, tetapi belum ada penelitian untuk mengukur kadar nitrit oksida (NO). Penelitian ini bertujuan mengetahui pengaruh penanaman benang catgut terhadap kadar NO serum dan tekanan darah pada hipertensi esensial.
Disain penelitian adalah uji klinis acak tersamar tunggal dengan kontrol. Melibatkan 40 pasien hipertensi yang dibagi menjadi dua kelompok. Kelompok kontrol mendapatkan obat antihipertensi. Kelompok kasus mendapatkan obat antihipertensi dan penanaman benang catgut, kemudian pada kedua kelompok dilakukan penilaian kadar NO dan tekanan darah.
Hasil penelitian menunjukkan terdapat perbedaan rerata kadar NO kelompok kasus dibandingkan kontrol (p<0,05), terdapat perbedaan rerata tekanan darah sistolik dan diastolik kelompok kasus dibandingkan kontrol (p<0,05). Dapat disimpulkan bahwa penanaman benang catgut memiliki pengaruh terhadap kadar NO serum dan tekanan darah pada pasien hipertensi esensial.
Hypertension is commonly seen in daily practice and its prevalence in indonesia is fairly high (31,7%). Catgut embedding is proven to reduce blood pressure, but until now there has not been any research to evaluate concentration of nitric oxide (NO). This research was to assess the effect of catgut embedding on serum NO concentration and blood pressure in essential hypertension.
Research design was single blind random controlled clinical trial, involving 40 hypertension patients randomly assigned to two groups. Control group received anti hypertension drugs whereas case group received anti hypertension drugs and catgut embedding and then the two groups evaluated for NO concentration and blood pressure.
Result showed that there was a mean difference of NO concentration between case group and control group (p<0,05) and mean difference of systolic and diastolic blood pressure between case group and control group (p<0,05). In conclusion, catgut embedding can influence serum NO concentration and blood pressure in essential hypertension patients."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Tugas Akhir  Universitas Indonesia Library
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Tasya Wijayanti
Analisis Efektivitas Biaya Amlodipin dibandingkan Kaptopril pada Pasien Hipertensi Rawat Jalan di Rumah Sakit Umum Daerah Ciracas Tahun 2020-2021 = Cost Effectiveness Analysis of Amlodipine Compared to Captopril in Treatment for Hypertension Outpatients at the Ciracas Regional General Hospital in the Period 2020-2021
"Hipertensi adalah penyakit dengan prevalensi tinggi di Indonesia dengan persentase 34,11% pada populasi lebih dari 18 tahun. Penelitian terdahulu di Indonesia menyatakan bahwa Amlodipin lebih cost-effective apabila dibandingkan dengan kaptopril. Penelitian ini bertujuan untuk menganalisis efektivitas biaya yang lebih baik antara terapi Amlodipin dan Kaptopril pada pasien Hipertensi rawat jalan di RSUD Ciracas. Pada penelitian ini digunakan desain penelitian Cross Sectional dengan menggunakan data rekam medis pasien, yaitu nilai tekanan darah, jenis kelamin, usia, dan komorbiditas. Selain itu, digunakan data billing pasien dilihat dari perspektif rumah sakit yang terdiri atas biaya obat, biaya obat lain, biaya laboratorium, biaya administrasi, dan total biaya pengobatan. Sampel yang digunakan pada penelitian ini sebanyak 60 sampel, yang terdiri atas 40 sampel kelompok amlodipin dan 20 sampel kelompok kaptopril. Berdasarkan hasil penelitian, didapatkan nilai inkremental efektivitas antara kedua terapi sebesar 20%. Kemudian didapatkan nilai inkremental biaya antara kedua terapi sebesar Rp84.079. Sementara itu, berdasarkan perhitungan didapatkan Rasio Efektivitas Biaya (REB) untuk amlodipin adalah sebesar Rp394.124 dan untuk terapi kaptopril adalah sebesar Rp384.572. Berdasarkan tabel efektivitas biaya, hasil analisis menunjukkan bahwa terapi amlodipin dan kaptopril memiliki efektivitas dan biaya yang setara.
Hypertension is a disease with high prevalence in Indonesia with a percentage of 34,11% in the population over 18 years. Previous research in Indonesia stated that amlodipine is more cost-effective when compared to kaptopril. This study aims to analyze the better cost-effectiveness of amlodipine and captopril therapy in hypertension outpatients at the Ciracas Regional General Hospital in the period 2020-2021. This study used a cross sectional research design which using patient medical record data, consist of blood pressure value, gender, age, and commorbidities. In addition, this study used patient billing data from a hospital perspective, consist of drug costs, other drug costs, laboratory costs, administration, and the total cost of treatment. The samples used in this study were 60 samples, consisting of 40 samples from the amlodipine group and 20 samples from the captopril group. Based on the results of the study, the incremental value of effectiveness between the two therapies was 20%. Then the incremental cost value between the two therapies was Rp84,079. Meanwhile, based on the calculation of the Average Cost Effectiveness Ratio (ACER) for amlodipine group was Rp394,124 and for captopril group was Rp384,572. Based on the cost-effectiveness table, the results of the analysis show that amlodipine and captopril therapy have the same effectiveness and cost."
Depok: Fakultas Farmasi Universitas Indonesia, 2022
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UI - Skripsi Membership  Universitas Indonesia Library
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Tri Cahyo Sepdianto
Pengaruh latihan slow deep breathing terhadap penurunan tekanan darah dan tingkat kecemasan pasien hipertensi primer di Kota Blitar = The effect of slow deep breathing exercise on decreasing blood pressure and anxiety level of patients with primary hypertension / Tri Cahyo Sepdianto
"ABSTRAK
Slow deep breathing adalah tindakan non farmakologi pada pasien hipertensi primer yang
dapat menurunkan tekanan darah dan tingkat kecemasan. Tujuan penelitian untuk
mengidentifikasi penurunan tekanan darah dan tingkat kecemasan pasien hipertensi primer
setelah melakukan latihan slow deep breathing antara kelompok intervensi dan kelompok
kontrol di Puskesmas Kepanjen Kidul dan Sukorejo Kota Blitar. Metodologi penelitian ini
merupakan penelitian kuantitatif dengan desain Quasi-Experimental Pretest-Posttest
Control Group. Sampel penelitian terdiri dari 56 responden, 28 responden menjadi
kelompok intervensi dan 28 responden menjadi kelompok kontrol. Pengambilan sampel
dilakukan dengan cara purposive sampling. Hasil penelitian menunjukkan perbedaan
penurunan rata-rata tekanan darah sistolik sebesar 15,5 mmHg, perbedaan penurunan ratarata
tekanan darah diastolik sebesar 9,9 mmHg dan perbedaan penurunan rata-rata skor
tingkat kecemasan sebesar 3,2. Analisis lebih lanjut menunjukkan ada perbedaan penurunan
yang signifikan rata-rata tekanan darah sistolik, tekanan darah diastolik dan tingkat
kecemasan antara kelompok intervensi dengan kelompok kontrol (p = 0,000,  = 0,05).
Penelitian ini menyimpulkan latihan slow deep breathing dapat menurunkan secara
signifikan tekanan darah dan tingkat kecemasan pasien hipertensi primer di Puskesmas
Kepanjen Kidul dan Sukorejo Kota Blitar. Latihan Slow deep breathing dalam pelayanan
keperawatan dapat digunakan sebagai intervensi keperawatan mandiri dalam memberikan
asuhan keperawatan pada pasien hipertensi primer. Rekomendasi dari penelitian ini adalah
perlu dilakukan penelitian lanjutan dengan jumlah sampel yang lebih besar dan kondisi
pasien yang lebih kompleks serta melihat perubahan pada tanda-tanda vital yang lain
seperti denyut nadi dan frekuensi pernafasan.
ABSTRACT
Slow deep breathing is a non pharmacological intervention for patients with primary
hypertension. The intervention can reduce blood pressure and anxiety level. The purpose of
this study was to identify the reduction of blood pressure and anxiety level of patients with
primary hypertension after slow deep breathing exercise between intervention and control
groups at Puskesmas Kepanjen Kidul and Sukorejo Blitar. This research utilized a Quasi-
Experimental Pre – post test Control Group design. There were 56 respondents participated
in the study, consisted of 28 subjects for each group; intervention and control groups using
a purposive sampling method. The result showed that there was a decrease of 9.9 mm Hg in
the average of systolic blood pressure and the anxiety level of 3.2 after the intervention.
Further result demonstrated that there was a significant reduction of the average systolic
and diastolic pressure, and anxiety level between intervention and control groups (p=0.00,
=0.05). The findings revealed that the slow deep breathing exercise decreased the blood
pressure and anxiety level in patients with primary hypertension at Kepanjen Kidul and
Sukorejo Blitar. Therefore, the slow deep breathing exercise could be applied as one of the
independent nursing therapies in nursing care of patients with primary hypertension.
Anyhow, a further research with larger number of samples, involving more variables to
examine such as pulse and respiration rate, and also in patients with more complex
condition is recommended."
Fakultas Ilmu Keperawatan Universitas Indonesia, 2008
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UI - Tesis Open  Universitas Indonesia Library
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