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"[Munculnya berbagai tantangan baru dalam pengendalian TB, salah satunya multidrug resistant tuberculosis (TB MDR). TB MDR adalah salah satu jenis resistensi TB yang disebabkan oleh bakteri Mycobacterium tuberculosis yang tidak merespon (resisten), setidaknya, isoniazid dan rifampicin yang merupakan dua jenis obat yang paling efektif pada lini pertama obat anti TB (OAT). Penelitian bertujuan untuk mengetahui faktor-faktor yang mempengaruhinyakonversi kultur sputum pada pasien TB Paru MDR. Penelitian dilakukan di dilakukan di RSUD Labuang Baji Kota Makassar dimulai dari bulan April 2015-Juni 2015. Desain penelitian adalah kohort retrospektif. Jumlah sampel dalam penelitian ini yakni 183 pasien, 139 pasien (76,0%) yang mengalami konversi kultur sputum, 4 pasien (2,2%) yang tidak mengalami konversi kultur sputum, dan 40 pasien (21,8%) yang loss to follow up. Dari penelitian ini diketahui bahwa probabilitas konversi kultur sputum pasien TB paru MDR sebesar 95,52%. Hasilanalisis multivariat menunjukkan bahwa interupsi pengobatan (HR:0,45; 95%CI: 0,26-0,79), status diabetes melitus (DM) sebelum 33 hari (HR:0,75; 95%CI: 0,29- 1,95) dan setelah 33 hari yakni (HR:1,95; 95%CI: 0,90-7,60), serta riwayat pengobatan yang pernah mendapatkan OAT lini I (HR:0,32; 95%CI: 0,12-0,90) serta yang pernah mendapatkan OAT lini II (HR:0,27; 95%CI: 0,10-0,77). Diperlukan penanganan secara intensif dan lengkap pada pasien TB paru MDR di Poli TB MDR dengan memperhatikan interupsi pengobatan, status DM, dan riwayat pengobatan sebelumnya;One of the new emerging challenges in TB controlling is multidrug resistant tuberculosis (MDR TB). MDR TB is a type of TB resistant caused by the unresponsiveness (resistancy) of Mycobacterium tuberculosis to at least isoniazid and rifampicin in which both are the most effective anti-TB drugs in first line. This study was aimed to determine the influencing factors for the timing ofsputum culture conversion among pulmonary MDR TB patients. This study was conducted in Labuang Baji General Hospital, Makassar City started from April 2015 to June 2015. Cohort-retrospective design was performed in this study. There were 183 patients involved in this study consisted of 139 (76,0%) patients with sputum culture conversion, 4 (2,2%) patients with no sputum culture conversion, and 40 (21,8%) patients were loss to follow up. The result of the study shows that the probability of sputum culture conversion of Pulmonary MDR TB was 95,52%. Multivariate analysis showed that the interruption of treatment(HR:0,45; 95%CI: 0,26-0,79), Diabetes Mellitus (DM) before 33 days (HR:0,75; 95%CI: 0,29-1,95), DM after 33 days (HR:1,95; 95%CI: 0,90-7,60), previously treated with FLDs (HR:0,32; 95%CI: 0,12-0,90), and previously treated with SLDs (HR:0,27; 95%CI: 0,10-0,77) were found to be the influencing factors for the sputum culture conversion among pulmonary MDR TB. Complete and intensive care are needed among pulmonary MDR TB in MDR TB polyclinic by observing the interruption of treatment, DM, and history of previous treatment.;One of the new emerging challenges in TB controlling is multidrug resistanttuberculosis (MDR TB). MDR TB is a type of TB resistant caused by theunresponsiveness (resistancy) of Mycobacterium tuberculosis to at least isoniazidand rifampicin in which both are the most effective anti-TB drugs in first line.This study was aimed to determine the influencing factors for the timing ofsputum culture conversion among pulmonary MDR TB patients. This study wasconducted in Labuang Baji General Hospital, Makassar City started from April2015 to June 2015. Cohort-retrospective design was performed in this study.There were 183 patients involved in this study consisted of 139 (76,0%) patientswith sputum culture conversion, 4 (2,2%) patients with no sputum cultureconversion, and 40 (21,8%) patients were loss to follow up. The result of thestudy shows that the probability of sputum culture conversion of Pulmonary MDRTB was 95,52%. Multivariate analysis showed that the interruption of treatment(HR:0,45; 95%CI: 0,26-0,79), Diabetes Mellitus (DM) before 33 days (HR:0,75;95%CI: 0,29-1,95), DM after 33 days (HR:1,95; 95%CI: 0,90-7,60), previouslytreated with FLDs (HR:0,32; 95%CI: 0,12-0,90), and previously treated withSLDs (HR:0,27; 95%CI: 0,10-0,77) were found to be the influencing factors forthe sputum culture conversion among pulmonary MDR TB. Complete andintensive care are needed among pulmonary MDR TB in MDR TB polyclinic byobserving the interruption of treatment, DM, and history of previous treatment.;One of the new emerging challenges in TB controlling is multidrug resistanttuberculosis (MDR TB). MDR TB is a type of TB resistant caused by theunresponsiveness (resistancy) of Mycobacterium tuberculosis to at least isoniazidand rifampicin in which both are the most effective anti-TB drugs in first line.This study was aimed to determine the influencing factors for the timing ofsputum culture conversion among pulmonary MDR TB patients. This study wasconducted in Labuang Baji General Hospital, Makassar City started from April2015 to June 2015. Cohort-retrospective design was performed in this study.There were 183 patients involved in this study consisted of 139 (76,0%) patientswith sputum culture conversion, 4 (2,2%) patients with no sputum cultureconversion, and 40 (21,8%) patients were loss to follow up. The result of thestudy shows that the probability of sputum culture conversion of Pulmonary MDRTB was 95,52%. Multivariate analysis showed that the interruption of treatment(HR:0,45; 95%CI: 0,26-0,79), Diabetes Mellitus (DM) before 33 days (HR:0,75;95%CI: 0,29-1,95), DM after 33 days (HR:1,95; 95%CI: 0,90-7,60), previouslytreated with FLDs (HR:0,32; 95%CI: 0,12-0,90), and previously treated withSLDs (HR:0,27; 95%CI: 0,10-0,77) were found to be the influencing factors forthe sputum culture conversion among pulmonary MDR TB. Complete andintensive care are needed among pulmonary MDR TB in MDR TB polyclinic byobserving the interruption of treatment, DM, and history of previous treatment.;One of the new emerging challenges in TB controlling is multidrug resistanttuberculosis (MDR TB). MDR TB is a type of TB resistant caused by theunresponsiveness (resistancy) of Mycobacterium tuberculosis to at least isoniazidand rifampicin in which both are the most effective anti-TB drugs in first line.This study was aimed to determine the influencing factors for the timing ofsputum culture conversion among pulmonary MDR TB patients. This study wasconducted in Labuang Baji General Hospital, Makassar City started from April2015 to June 2015. Cohort-retrospective design was performed in this study.There were 183 patients involved in this study consisted of 139 (76,0%) patientswith sputum culture conversion, 4 (2,2%) patients with no sputum cultureconversion, and 40 (21,8%) patients were loss to follow up. The result of thestudy shows that the probability of sputum culture conversion of Pulmonary MDRTB was 95,52%. Multivariate analysis showed that the interruption of treatment(HR:0,45; 95%CI: 0,26-0,79), Diabetes Mellitus (DM) before 33 days (HR:0,75;95%CI: 0,29-1,95), DM after 33 days (HR:1,95; 95%CI: 0,90-7,60), previouslytreated with FLDs (HR:0,32; 95%CI: 0,12-0,90), and previously treated withSLDs (HR:0,27; 95%CI: 0,10-0,77) were found to be the influencing factors forthe sputum culture conversion among pulmonary MDR TB. Complete andintensive care are needed among pulmonary MDR TB in MDR TB polyclinic byobserving the interruption of treatment, DM, and history of previous treatment.;One of the new emerging challenges in TB controlling is multidrug resistanttuberculosis (MDR TB). MDR TB is a type of TB resistant caused by theunresponsiveness (resistancy) of Mycobacterium tuberculosis to at least isoniazidand rifampicin in which both are the most effective anti-TB drugs in first line.This study was aimed to determine the influencing factors for the timing ofsputum culture conversion among pulmonary MDR TB patients. This study wasconducted in Labuang Baji General Hospital, Makassar City started from April2015 to June 2015. Cohort-retrospective design was performed in this study.There were 183 patients involved in this study consisted of 139 (76,0%) patientswith sputum culture conversion, 4 (2,2%) patients with no sputum cultureconversion, and 40 (21,8%) patients were loss to follow up. The result of thestudy shows that the probability of sputum culture conversion of Pulmonary MDRTB was 95,52%. Multivariate analysis showed that the interruption of treatment(HR:0,45; 95%CI: 0,26-0,79), Diabetes Mellitus (DM) before 33 days (HR:0,75;95%CI: 0,29-1,95), DM after 33 days (HR:1,95; 95%CI: 0,90-7,60), previouslytreated with FLDs (HR:0,32; 95%CI: 0,12-0,90), and previously treated withSLDs (HR:0,27; 95%CI: 0,10-0,77) were found to be the influencing factors forthe sputum culture conversion among pulmonary MDR TB. Complete andintensive care are needed among pulmonary MDR TB in MDR TB polyclinic byobserving the interruption of treatment, DM, and history of previous treatment., One of the new emerging challenges in TB controlling is multidrug resistanttuberculosis (MDR TB). MDR TB is a type of TB resistant caused by theunresponsiveness (resistancy) of Mycobacterium tuberculosis to at least isoniazidand rifampicin in which both are the most effective anti-TB drugs in first line.This study was aimed to determine the influencing factors for the timing ofsputum culture conversion among pulmonary MDR TB patients. This study wasconducted in Labuang Baji General Hospital, Makassar City started from April2015 to June 2015. Cohort-retrospective design was performed in this study.There were 183 patients involved in this study consisted of 139 (76,0%) patientswith sputum culture conversion, 4 (2,2%) patients with no sputum cultureconversion, and 40 (21,8%) patients were loss to follow up. The result of thestudy shows that the probability of sputum culture conversion of Pulmonary MDRTB was 95,52%. Multivariate analysis showed that the interruption of treatment(HR:0,45; 95%CI: 0,26-0,79), Diabetes Mellitus (DM) before 33 days (HR:0,75;95%CI: 0,29-1,95), DM after 33 days (HR:1,95; 95%CI: 0,90-7,60), previouslytreated with FLDs (HR:0,32; 95%CI: 0,12-0,90), and previously treated withSLDs (HR:0,27; 95%CI: 0,10-0,77) were found to be the influencing factors forthe sputum culture conversion among pulmonary MDR TB. Complete andintensive care are needed among pulmonary MDR TB in MDR TB polyclinic byobserving the interruption of treatment, DM, and history of previous treatment.]"

"Penyakit TB MDR merupakan salah satu penyakit infeksi yang prevalensinya semakin meningkat dari tahun ke tahun di Indonesia dengan angka keberhasilan pengobatan 45%. Konversi kultur sputum merupakan suatu prediktor kuat dari awal keberhasilan terapi. Waktu konversi yang lambat akan memperpanjang periode penularan dan memprediksi tingkat kegagalan pengobatan yang tinggi. Terdapat beberapa faktor risiko yang berhubungan dengan konversi kultur sputum pasien TB MDR. Penelitian terkait faktor risiko kadar albumin dengan waktu konversi kultur sputum masih sangat terbatas. Tujuan penelitian ini adalah untuk mengetahui hubungan kadar albumin dengan waktu konversi kultur sputum di poli MDR terpadu RS Paru Dr M Goenawan Partowidigdo tahun 2022. Penelitian ini menggunakan studi cohort retrospektif dengan sampel yang diambil dari catatan rekam medis dan SITB pasien poli MDR. Variabel yang diteliti adalah kadar albumin < 3,5 gram/dl dan ≥ 3,5 gram/dl dengan variabel covariat usia, jenis kelamin, pendidikan, index masa tubuh, status merokok, gradasi sputum bta, komorbid, regimen pengobatan, dan kepatuhan minum obat . Hasil penelitian berdasarkan analisis multivariat menunjukkan kadar albumin < 3,5 mg/dl memiliki kecepatan waktu konversi 41,8% lebih lambat dengan (HR=0,582, 95% CI 0.344-0.984) untuk mengalami konversi dibanding dengan pasien TB MDR dengan kadar albumin ≥ 3,5 mg/dl setelah memperhitungkan status merokok dan kepatuhan minum obat. Perlunya memperbaiki kadar albumin yang rendah pada pasien TB MDR di rumah sakit dan memberikan penyuluhan kepada keluarga pasien agar turut berpartisipasi memantau asupan makan pasien yaitu makanan yang mengandung tinggi protein seperti ikan gabus serta ekstra putih telur untuk membantu meningkatkan kadar albumin pasien yang dapat berguna untuk terjadinya konversi kultur sputum.

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MDR TB disease is an infectious disease whose prevalence is increasing from year to year in Indonesia with a treatment success rate of 45%. Sputum culture conversion is a strong predictor of initial therapeutic success. Slow conversion time will prolong the period of transmission and predict a high rate of treatment failure. There are several risk factors associated with sputum culture conversion in MDR TB patients. Research related to risk factors for albumin levels and sputum culture conversion time is still very limited. The aim of this study was to determine the relationship between albumin levels and sputum culture conversion time at the integrated MDR polyclinic at Dr M Goenawan Partowidigdo Pulmonary Hospital in 2022. This study used a retrospective cohort study with samples taken from medical records and SITB patients at poly MDR. The variables studied were albumin levels < 3.5 mg/dl and ≥ 3.5 mg/dl with the covariate variables age, sex, education, body mass index, smoking status, sputum gradation, co-morbidities, medication regimens, and drinking adherence drug . The results of the study based on multivariate analysis showed that albumin levels < 3.5 mg/dl had a 41.8% slower conversion time (HR=0.582, 95% CI 0.344-0.984) to experience conversion compared to MDR TB patients with albumin levels ≥ 3.5 mg/dl after taking into account smoking status and medication adherence. It is necessary to improve low albumin levels in MDR TB patients at the hospital and provide counseling to the patient's family to participate in monitoring the patient's food intake, namely foods that contain high protein such as snakehead fish and extra egg whites to help increase the patient's albumin levels which can be useful for the occurrence of sputum culture conversion."

"ABSTRAKLatar Belakang : Tuberkulosis (TB) adalah penyakit infeksi menular yang disebabkan oleh bakteri Mycobacterium tuberculosiss (MTB) dan merupakan masalah kesehatan utama didunia.1World Health Organization (WHO) pada tahun 2018 melaporkan 10 juta orang terdiagnosis TB di seluruh dunia. Indonesia merupakan negara dengan insiden TB tertinggi ketiga di dunia, terjadi peningkatan kasus baru sebesar 70% dari 331.703 menjadi 563.879 antara tahun 2015-2018 dan kasus TB MDR/TB RR, rata-rata 8.8 per 100.000 populasi, 2.4 % merupakan kasus baru dan dan 13% merupakan TB pengobatan ulang.2Berdasarkan data WHO tingkat kegagalan pengobatan pada pasien TB MDR cukup besar (lebih dari 50%), juga terjadi di Indonesia yang disebabkan tinggi nya angka kematian (17%) dan loss to follow up (26%). Kegagalan pengobatan mengakibatkan pengobatan dihentikan dan diperlukan penggantian rejimen. Komorbiditas, Efek samping obat, resistensi obat merupakan faktor yang mempengaruhi kegagalan pengobatan dan dinilai melalui konversi sputum yang merupakan indikator respons pengobatan dan digunakan sebagai indikator keberhasilan pengobatan atau kegagalan pengobatan.Tujuan : Mengetahui hubungan konversi sputum pasien TB MDR dengan berbagai faktor non genetic dan genetic yang terjadi selama fase intensif yang sedang diobati di RS paru DR.M.Goenawan Partowidigdo.Metode: Data diambil secara kohort retrospektif melalui rekam medis TB MDR (1 Oktober 2018 sampai 31 Maret 2019). Data yang terkumpul dilakukan uji statistik.Hasil : SP yang mendapat terapi jenis STR memiliki karakteristik rerata usia sebesar 35,11 tahun dengan jenis kelamin laki-laki sedikit lebih banyak dibanding perempuan (57,9% vs 42,1%), sebagian besar memiliki riwayat pengobatan TB sebelumnya (84,2%) namun tidak memiliki riwayat kontak dengan pasien TB aktif (87,7%). Terdapat 32 SP yang tidak memiliki riwayat pengobatan dan tidak memiliki riwayat kontak tetapi terinfeksi kuman TB MDR sebanyak sepertiga SP memiliki komorbiditas DM.SP yang mendapat terapi jenis konvensional memiliki karakteristik rerata usia sebesar 40,22 tahun, lebih banyak berjenis kelamin laki-laki (61,5%), dengan riwayat pengobatan TB sebelumnya (73,5%) namun tidak memiliki riwayat kontak dengan pasien TB aktif (86,3%), sebanyak sepertiga SP memiliki komorbiditas DMSubjek yang tidak mememiliki komorbiditas dan tidak konversi sputum sebesar 18,4% sedangkan yang tidak memiliki komorbiditas dan tidak konversi sputum sebesar 55,2% dimana hasil ini bermakna secara statistik (p=0,016, RO 2,23 IK95% 1,15 - 4,32). SP dengan DM memiliki risiko 2,23 kali untuk tidak terjadi konversi sputum. Jumlah efek samping obat anti tuberkulosis lebih dari 2 jenis yang mengalami konversi sputum sebesar 43,1 % sedangkan yang jumlah efek sampingnya ≤ 2 mengalami konversi sputum sebesar 23,6 % dimana hasil ini bermakna secara statistik (p<0,001, RO 0,11 IK95% 0,05 -0,25). Pada akhir bulan keenam dan dilakukan kultur dan DST dan LPA lini dua didapatkan perubahan sifat resistensi, bisa akibat mutasi atau pasien terinfeksi oleh 2 strain yang berbeda.Kesimpulan: Konversi kultur sputum yang tertunda mengakibatkan waktu pengobatan yang diperpanjang dan beresiko kegagalan pengobatan. DM, efek samping onat dan resistensi adalah salah satu Faktor yang menyebabkan waktu konversi sputum lebih lama, sehingga resiko kegagalan terapi menyebabkan resiko mortalitas meningkat.

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ABSTRACTBackground: Tuberculosis (TB) is an infection caused by Mycobacterium tuberculosis (MTB) and is a main health problem in the world.1 The World Health Organization (WHO) in 2018 reported 10 million people diagnosed with TB worldwide. Indonesian is country with the third highest incidence of TB in the world, an increase in new cases is 70% from 331,703 to 563,879 between 2015-2018 and MDR TB cases an average of 8.8 per 100,000 population, 2.4% is a new cases and 13% is a re-treatment of TB cases.2Based on WHO data, the treatment failure rate in MDR TB patients is quite large (more than 50%), also occurring in Indonesia which causes high mortality (17%) and loss to follow-up (26%). Treatment failure causes the treatment being stop and replacement regimen are needed. Many factors that influence treatment and approved through sputum conversion which is an indicator of treatment response and is used as an indicator of treatment success or treatment failure.Objective: To know the relation of sputum conversion in patients with various factor non genetic and genetic that occur during intensive phase while in the process of treatment in pulmonary hospital of Dr. M. Goenawan Partowidigdo.Methods: Data were collected in retrospective cohort through MDR TB medical records (1 October 2018 until 31 March 2019). The data collected is done by statistical tests.Results: SP who received STR type therapy had characteristic a mean age of 35.11 years with sex of male more slightly than female (57.9% vs 42.1%), most had a history medication of previous treatment TB (84, 2%) but do not have a contact history with active TB patients (87.7%). There were 32 SPs who had no history of treatment and had no contact history but were infected with MDR TB as much as one third of SP have comorbid DM.SP who received individua type of therapy had a mean age of 40.22 years, most are male (61.5%), with a history of previous TB treatment (73.5%) but had no contact history with active TB patients (86.3%), as many as one third of SP have comorbid DM.Subjects who did not have comorbidity and no sputum conversion were 18.4% while those who did not have comorbidity and had no sputum conversion were 48.9% where these results were statistically significant (p = 0.016, RO 2.23 IK95% 1.15 - 4 , 32). SP with DM has a risk of 2.23 times for not occur sputum conversion. The number of side effects of anti tuberculosis drugs more than 2 types be through sputum conversion was 43.1% while the number of side effects ≤ 2 be through sputum conversion was 23.6% where these results were statistically significant (p <0.001, RO 0.11 IK95 % 0.05 - 0.25). At the end of the sixth month and culture had be done and DST and LPA line two, there was a change of characteristic resitence, it could be due to mutations or the patient was infected by 2 different strains.Conclusion: Delayed conversion of sputum culture causes the time extended of treatment and risk treatment failure. DM, drugs side effects and resistance are one of the factors that cause a longer sputum conversion time, so the risk of therapy failure causes an increased risk of mortality."

"Penyakit tuberkulosis masih menjadi masalah kesehatan masyarakat yang utama di Indonesia baik dalam hal prevalensinya maupun masalah-masalah lainnya yang ditimbulkannya. Upaya dalam penanggulangan penyakit tuberkulosis masih terus dilakukan. Namun dalam perjalanannya banyak hambatan dalam upaya tersebut, salah satunya adalah adanya fenomena tuberkulosis multidrug resistant (TB-MDR). Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berpengaruh terhadap kejadian TB-MDR. Desain penelitian yang digunakan adalah kasus-kontrol dengan populasinya pasien TB di RSUP Persahabatan tahun 2013. Penelitian ini menghasilkan bahwa faktor-faktor yang berpengaruh terhadap kejadian TB-MDR di RSUP Persahabatan adalah umur (OR 1,7; 95%CI 0,7-4,1), konsumsi alkohol (OR 1,5; 95%CI 0,5-4,5), riwayat kontak TB (OR 2,1; 95%CI 0,8-5,2), kepatuhan minum obat (OR 10,8; 95%CI 4,4-26,8), status gizi (OR 3,3; 95%CI 1,4-7,8) dan diabetes mellitus (OR 2,1; 0,7-5,8). Penelitian tersebut menunjukkan bahwa untuk mendukung pelaksanaan program DOTS, penderita TB harus terus dimonitoring dan dikontrol selama pengobatannya terutama dalam hal kepatuhan dalam minum obat.

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Tuberculosis remains a major problem of public health in Indonesia, both in terms of prevalence and other problems it causes. An attempt of the tuberculosis prevention is still underway. But along the way there are a lot of obstacles in it, one of which is a phenomenon of multidrug-resistant tuberculosis (MDR-TB). This study intended to find the factors that affecting the MDR-TB. The design study is a case-controland the population is patients with TB at RSUP Persahabatan in 2013.

This study found that affected is the factors in MDR-TB at RSUP Persahabatan are the age (OR 1.7; 95%CI 0.7-4.1), alcohol consumption (OR 1.5; 95%CI 0.5-4.5), history of TB contact (OR 2.1; 95%CI 0.8-5.2), medication compliance (OR 10.8; 95%CI 4.4-26.8), nutritional status (OR 3.3; 95%CI 1.4-7.8) and diabetes mellitus (OR 2.1; 95%CI 0.7-5.8). The study showed that to support the implementation of DOTS program, TB patients should be closely monitored and controlled during treatment, especially in terms of medication compliance. "

"Latar Belakang: Anemia diketahui sebagai salah satu komplikasi pada penyakit TB. Konsentrasi hemoglobin yang rendah diasosiasikan dengan keterlambatan waktu konversi kultur sputum pada pasien TB namun hubungannya pada pasien TB MDR masih belum diketahui. Konversi kultur sputum pasien TB MDR dari positif menjadi negatif merupakan prediktor utama indicator keberhasilan pengobatan. Penelitian ini bertujuan untuk mengetahui apakah kondisi anemia pada pasien TB MDR dapat memperlambat waku konversi sputum. Metode: Penelitian ini menggunakan desain studi kohort retrospektif dengan metode total sampling untuk memperoleh data pemeriksaan hematologis, status klinis, dan status demografis dari rekam medis pasien TB MDR di RSUP Persahabatan selama tahun 2016. Data mengenai waktu konversi sputum diperoleh dari database online Indonesia, e-TB-Manager, di bawah pengawasan pihak yang berwenang di RSUP Persahabatan. Hasil: Dari seluruh 363 rekam medis, terdapat 201 data yang memenuhi kriteria inklusi dengan keterangan sebanyak 83/118 41.3 mengalami anemia. Analisis data dengan uji kesintasan menunjukkan bahwa status anemia memiliki pengaruh yang signifikan terhadap keterlambatan konversi sputum, sedangkan klasifikasi dan jenis anemia tidak memiliki pengaruh yang signifikan terhadap proses konversi sputum. Kesimpulan: Kondisi anemia meningkatkan risiko konversi sputum yang lebih lama pada pasien TB MDR dibandingkan dengan pasien tanpa diserta anemia. Oleh karena itu, perlu adanya upaya perbaikan status gizi dan profil hematologis pada pasien TB MDR yang disertai dengan anemia.

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Background: Anemia was known to be the complication of Tuberculosis TB . Low hemoglobin concentration was associated with prolonged time of culture sputum conversion in TB but the association in MDR TB is still unknown. Sputum culture conversion in MDR TB was the main predictor of successful therapy outcome. This study aims to understand whether anemia amongs MDR TB patients could prolong the time for sputum conversion.

Method: This retrospective cohort study used total sampling method to obtain hematological laboratory data, clinical status, and demographic status from medical records of MDR TB patients in Persahabatan Hospital during the year of 2016. The time of sputum conversion was obtained from Indonesian online database e TB Manager under supervision of Persahabatan Hospital authorized staffs.

Result: Of the 363 medical records within a year, only 201 datas fitted into inclusion criteria in which 83 of 118 MDR TB patients 41.3 have anemia. Survival analysis rate showed a significant rate difference in conversion time based on the anemic status. However, there is no significant relation of classification and types of anemia towards the conversion time.

Conclusion: Anemia increased the risk of prolonged time in spuum conversion in MDR TB patients compared to those without anemia. Therefore, there should be an effort in improving the nutritional status and hematological profile in MDRt TB patients with anemia."

"Tuberkulosis (TB) Paru merupakan salah satu penyakit penyebab utama kesakitan dan kematian di seluruh dunia. Pada tahun 2020 penyakit TB menempati peringkat kedua penyebab utama kematian akibat infeksi agen tunggal. Infeksi TB pada anak masih menjadi salah satu penyebab mortalitas dan morbiditas sehingga dibutuhkan tindakan preventif dan promotif yang tepat untuk menurunkan angka insiden TB salah satunya dengan mengevaluasi faktor-faktor risiko kejadian TB paru pada anak. Tujuan penelitian ini adalah untuk mengetahui faktor risiko yang berhubungan dengan kejadian TB paru pada anak di Kota Bekasi tahun 2022. Penelitian ini menggunakan studi kasus-kontrol dengan sampel 135 kasus dan 135 kontrol yang diambil berdasarkan data SITB Kota Bekasi. Variabel yang diteliti antara lain usia, jenis kelamin, status gizi, status vaksinasi BCG, riwayat kontak serumah dengan penderita TB, tingkat pendidikan orang tua, pekerjaan orang tua, kepadatan hunian, ventilasi rumah, dan sumber pencahayaan. Hasil penelitian berdasarkan analisis multivariat menunjukkan faktor risiko usia 0 - ≤5 tahun (OR 2,27; 95% CI: 1,22-4,22), status vaksinasi BCG negatif (OR 7,96; 95% CI: 2,02-31,40), status gizi kurang (OR 13,24; 95% CI: 5,44-32,22), riwayat kontak TB serumah lebih dari 4 minggu (OR 4,52; 95% CI: 2,41-8,48), dan pencahayaan rumah tidak memenuhi syarat (OR 2,39; 95% CI: 1,17-4,84) memiliki hubungan yang bermakna dengan kejadian TB paru pada anak di Kota Bekasi tahun 2022.

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Tuberculosis (TB) is one of the main causes of morbidity and mortality in worldwide. In 2020 TB disease is the second leading cause of death due to single agent infection. TB infection in children is still one of the causes of mortality and morbidity, so appropriate preventive and promotive measures are needed to reduce the incidence of TB, one of which is by evaluating the risk factors for pulmonary TB in children. The purpose of this study was to determine the risk factors associated with the incidence of pulmonary TB in children in Bekasi City in 2022. This study used a case-control study with a sample of 135 cases and 135 controls taken based on SITB from Bekasi City. The variables studied included age, gender, nutritional status, BCG immunization status, history of household contact with TB, parents' education level, parents' occupation, occupancy density, house ventilation, and lighting sources. The results of the study based on multivariate analysis showed that the risk factors were age 0 - ≤5 years (OR 2,27; 95% CI: 1,22-4,22), negative BCG immunization status (OR 7,96; 95% CI: 2,02-31,40), malnutrition status (OR 13,24; 95% CI: 5,44-32,22), history of contact with TB in the household for more than 4 weeks (OR 4,52; 95% CI: 2,41-8,48), and house lighting not requirements (OR 2,39; 95% CI: 1,17-4,84) has a significant relationship with the incidence of pulmonary TB in children in Bekasi City in 2022."

"Penanganan tuberkulosis (TB) di Indonesia masih dihadapkan pada keterlambatan pendeteksian terapi yang tidak adekuat. Secara klinis, kenaikan berat badan dianggap sebagai salah satu indikasi perbaikan klinis penderita TB yang praktis. Namun, apakah kenaikan berat badan benar berhubungan dengan kesembuhan klinis pasien TB masih perlu dibuktikan. Oleh karena itu, dalam upaya menilai potensi berat badan sebagai indikator klinis terapi TB, dilakukan riset yang bertujuan untuk melihat asosiasi antara penambahan berat badan dengan konversi sputum pada akhir fase inisial pengobatan anti-TB dengan kategori 1. Studi ini menggunakan desain kohort retrospektif dengan mengumpulkan data sekunder dari rekam medis pasien di RS Persahabatan pada tahun 2009 (n=102). Hasil menunjukkan bahwa 75,49% (n=77) pasien TB mengalami konversi sputum pada akhir fase inisial. Penambahan berat badan ditemukan pada sekitar setengah sampel dari grup dengan konversi sputum (51,95%) dan juga pada hampir setengah dari grup tanpa konversi sputum (dua belas dari 25). Studi ini menunjukkan bahwa penambahan berat badan tidak memiliki asosiasi yang signifikan dengan konversi sputum pada akhir fase inisial pengobatan anti-TB dengan kategori 1 selama dua bulan di RS Persahabatan (p= 0.732), namun studi lebih lanjut disarankan untuk meneliti asosiasi tersebut pada periode terapi yang lebih lama dan juga dengan mempertimbangkan IMT pasien.

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Tuberculosis (TB) management in Indonesia was facing delayed detection of inadequate therapies. Clinically, weight gain was considered as one of the simple indicators pointing towards clinical improvement of TB patients. However, whether weight gain was really associated with clinical recovery of TB patients was yet to be proven. Therefore, as an effort to assess the possibility of observing weight gain to evaluate anti-TB therapy, a research was conducted aiming to assess the association between weight gain and sputum conversion at the end of initial phase category 1 anti-TB therapy. This study used a retrospective cohort design by collecting secondary data from the medical records of TB patients in Persahabatan hospital in 2009 (n=102).

Results showed that 75.49% (n=77) of TB patients underwent sputum conversion at the end of second month of therapy. Regardless of sputum conversion, weight gain was observed in approximately half of both groups with (51.95%) and without (twelve out of 25) sputum conversion. This study revealed that weight gain was not significantly associated with sputum conversion at the end of two months initial phase category 1 anti-TB therapy in Persahabatan hospital (p= 0.732), however future studies were encouraged to explore the association in longer therapy period and with considering patients BMI."

"Tuberkulosis paru adalah salah satu penyakit yang muncul sebagai pembunuh yang disebabkan oleh salah satu jenis kuman yaitu Mycrobucterium tuberculosis. Delapan juta penduduk dunia diperkirakan mengidap penyakit TB Paru dengan tingkat kematian penderita sekitar tiga juta orang (33,3 %). Penyakit ini 75 % menyerang kelompok usia produktif (15-50 tahun) dan kematian yang diakibatkannya merupakan 25 % dan seluruh kematian yang sebenarnya dapat dicegah. Indonesia pada tahun 1999 menempati peringkat ketiga sebagai negara yang jumlah penderita TB Paru terbanyak setelah India dan Cina. Peningkatan kasus tuberkuliosis, dari hasil beberapa penelitian yang teiah dilakukan selama ini, dapat dipengaruhi oleh faktor-faktor lingkungan diantaranya adalah lingkungan fisik, karakteristik ,individu dan lingkungan sosial yang ada disekilar pemukinnan atau perumahan penduduk. Di Kabupaten Bengkulu Utara telah dilaksanakan upaya penemuan kasus secara terus-menerus, upaya ini mampu menemukan suspek TB Paru. Tahun 2001 dari 1307 suspek, diperiksa 5,121 specimen dan ditemukan penderita BTA (+) sebanyak 220 orang. Periode bulan Januari 2002 sampai dengan Desember 2002, jumlah specimen diperiksa sebanyak 5.343 specimen dari 1.781 orang dan ditemukan BTA (+) sebanyak 261 orang, sedangkan periode tahun 2003 dari 1687 suspek dan 5.061 specimen yang diperiksa ditemukan 258 orang dengan BTA (+). Penelitian ini menggunakan desain case control dengan menggunakan data primer dan sekunder, penelitian dilakukan di 16 (enam helas) Puskesmas wilayah Kabupeten Bengkulu yaitu Puskesmas Penimnas, Kota Arga Makmur, Air Lais, Air Bintunan, Lubuk Durian, Pekik Nearing, Lubuk Pinang, Sebelat, Napa] Putih, Ketahun, D6 Ketahun, Karang Pulau, Kerkap, Karang Tinggi, Taba Penanjung dan Puskesmas Kembang Seri, Pengambilan sampel dilakukan dengan Cara random sederhana sebanyak 182 sampel yang terdiri dari 91 sampel kasus dan 9I sampel bukan kasus. Uji hipotesis dalam penelitian ini menggunakan tahapan analisis univariat, bivariat dan multivariate. Variabel independen dalam penelitian adalah karakteristik individu (usia, jenis'kelamin, kontak penderita, riwayat imunisasi, perilaku, status gizi), lingkungan fisik (ventilasi, suhu, pencahayaan, kclembaban), lingkungan social (kepadatan penghuni, pendidikan, pengetahuan, penghasi]an). Hasil penelitian menunjukkan bahwa penghuni rumah kebun yang pcrnah kontak dengan penderita TB paru BTA (+) mcmpunyai risiko 5,09 kali, status gizi yang kurang mempunyai risiko 2,26 kali, kelembaban tidak memenuhi syarat mempunyai risiko 3,56 kali, kepadatan hunian tidak memenuhi syarat mempunyai risiko 2,716 kali, tingkat pengetahuan tentang penyakit TBC yang kurang mempunyai risiko 2,37 kali untuk terkena TB paru BTA (+). Saran yang dapat disampaikan, agar kegiatan program terkait di lingkungan Dinas Kesehatan Kabupaten Bengkulu Utara dapat melakukan penanganan masalah TB paru di rumah kebun ini melalui kegiatan pendataan dan pemetaan rumah kebun yang ada di tiap wilayah Puskesmas sehingga diperoleh gambaran populasi yang berisiko, penempatan fasilitas pelayanan kesehatan terdekat dengan rumah kebun,. melakukan koordinasi program gizi, P2M dan kesehatan Iingkungan serta promosi kesehatan.

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Pulmonary tuberculosis (TB) is a severe disease caused by the bacterium Mycobacterium tuberculosis. Around 8 million people suffer from pulmonary TB with a death rate of 3 million people (3,3 %). Approximately 75 % of the pulmonary TB cases occur in the productive age group (15-50 year old) and 23 % of deaths are actually preventable.

Indonesia in 1999 occupy the third rank as a country that have the most cases of pulmonary TB after India and China. From previous studies, there are several environmental factors that influence the increase of pulmonary TB cases, such as physical environment, individual characteristics, and the social environment surrounding the residences.

In north Bengkulu, continuous efforts have yielded new cases suspected as being pulmonary TB sufferer. In 200], out of 1,707 people suspected, 5,121 specimens were examined and those with BTA (+) were 220 people. During January to December 2002, there were 5,343 specimens examined from 1,78I people, end there were 261 of of those with BTA (+). In 2003, of of 1687 suspected, 5,061 specimens were examined and those with BTA (+) were 258 people.

Design of this studying case control study using primary an d secondary data, and was undertaken in 16 public health centers in Bengkulu district, namely Perumnas, Kota Arga Makmur, Air Lais, Air Bintunan, Lubuk Durian, Pekik Nyaring, Lubuk Pinang, Sebelat, Napa! Putih, Ketahun, D6 Ketahun, Karang Pulau, Kerkap, KarangTinggi, Taba Penanjung and Kembang Seri. Samples were collected using a sample random method, and there are 91 case 91 case samples and 91 control sample.

Hypothesis testing was done through univariate, bivariate. and multivariate analysis. Independent variables of this study include individual characteristics (age, sex, Ievel of education, knowledge, contact with TB sufferer, history of immunization, behavior, and nutritional status), physical environment (ventilation, temperature, the amount of light entering the house, and humidity), and social environment (density of house occupants, and income).

The result of the study show that occupant of plantation house that have had contact with a pulmonary TB BTA (-i) sufferer are 5.09 times more likely to suffer from pulmonary TB BTA (t]. There are risks 2,26 times more for those with poor nutritional status, 3.56 times for poor humadity, 2.72 times for high density of occupants, and 237 times for a lack of knowledge about pulmonary TB.

Recommendations that can be derived from this study are the implementation of programs by the district health service of North Bengkulu that include data recording of plantation houses in the areas around various public health centers, thus enabling the District Health Service to determine the population at risk for pulmonary TB. as well as building several several health service facilities that can be easily accessed from the plantation houses, coordinating programs on nutrition, control of infectious diseases, environment health and health promotion."

"Tuber kulosis paru merupakan masalah kesehatan utama dinegara berkembang penyakit ini merupakan penyebab kematian no 3 di Indonesia setelah radang pernafasan bawah, penyakit kardiovaskuler. Di negara berkembang setiap tahun 4 - 5 juta kasus penyakit TB paru menular yang timbul setiap tahun, dimana 8 juta penduduk terserang, 3 juta diantaranya meninggal dunia. Di Indonesia preevalensi TB paru dengan BTA + sebesar 0,29 % dari jumlah penduduk, kematian akibat TB paru lebih kurang 175 ribu penderita setiap tahun. Sumatera Barat prevalensi TB paru usia produktif adalah 5,3 %, cukup tinggi dari pada angka nasional. Keberhasilan pengobatan dan penyembuhan penyakit berhubungan dengan kepatuhan Penderita minum obat selama 2 bulan fase awal dan 4 bulan fase lanjutan sehingga memberikan dukungan dalam keberhasilan pengobatan. Tujuan penelitian ini untuk melihat faktor-faktor yang berhubungan dengan kepatuhan berobat penderita di poliklinik paru Rumah Sakit Dr. Ahmad Muchtar Bukit Tinggi tahun 2000. Waktu penelitian adalah dari bulan Januari 2000 sampai dengan Agustus 2000 dengan desain penelitian adalah potong lintang (cross sectional) populasi penelitian adalah penderita TB paru yang berobat di poliklinik Rumah Sakit Dr.Ahmad Muchtar Bukit Tinggi dengan jumlah sampel 100 orang dan pengumpulan data dilakukan dengan menggunakan kuesioner dan wawancara langsung. Hasil penelitian menunjukan 69 orang (69%) patuh dan 31 orang (31 %) penderita tidak patuh berobat. Analisis menghasilkan 5 variabel yaitu umur, pengetahuan, pendidikan, jarak rumah penderita, dan dukungan keluarga yang mempunyai hubungan bermakna (p 0,05) dengan kepatuhan berobat. Pertama umur, yang lebih 50 tahun berhubungan dengan kepatuhan berobat dengan odds Ratio 2,78 (95% CI; 1,16 - 6,05). Kedua hubungan antara pengetahuan yang kurang dengan kepatuhan berobat dimana Odds Ratio 14,74 (95% CI; 3,96 - 54,85). Ketiga pendidikan rendah berhubungan dengan kepatuhan berobat Odds Ratio 7,31 (95 % CI; 2,65 - 20,28). Keempat hubungan antara jarak rumah penderita dengan kepatuhan berobat Odds Ratio 3,20 (95% CI; 1,32 --1,75). Kelima hubungan antara dukungan keluarga dengan kepatuhan berobat Odds Ratio 2,57 (95% CI; 1,05 - 6,27). Dari hasil multivariat dengan metode regresi logistik dari 10 variabel bebas, hanya 8 variabel yang masuk sebagai kandidat untuk dianalisis. Hasilnya hanya 1 variabel yang dominan yaitu umur, pengetahuan pendidikan, pekerjaan, jenis kelamin, jarak, hubungan keluarga. Setelah dikontrol dengan variabel bebas lainnya beberapa kali, ternyata variabel determinan yaitu pendidikan dan jarak rumah ke rumah sakit. Untuk mengatasi ini perlu diadakan penerangan terus manerus bagi pengunjung poliklinik paru sebelum diadakan pelayanan pengobatan kesehatan serta perlu di bentuk pusat-pusat pelayanan penderita TB paue agar penderita tidak terlalu jauh datang ke poliklinik paru Rumah Sakit Dr.Ahmad Muchtar Bukit Tinggi.

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Lung Tuberculosis as main public health problem in the developing country. Indonesia is one of the country with high prevalence of tuberculosis disease, is third -death after cardiovascular disease, lower respiratory infection. In developing countries 4-5 million peoples were covered every year, which are 3 million is dead. Indonesia prevalence Lung Tuberculosis with Acid Flaccid Bacteria positive about 0,29% cases of people and death ± 175.000 peoples every year. West Sumatera more than national prevalence is 5,3% of productive age. Successfulness of disease of control and treatment program is related closely to patients compliance.

The aim of research to evident compliance treatment in polyclinic of Dr. Ahmad Muchtar Hospital Bukittinggi year 2000. The study was conducted on January to August 2000 by using cross sectional design. The population of this study was patients of Tuberculosis treatment with short course regiment at polyclinic of Dr. Ahmad Muchtar Hospital, have got Tuberculosis drugs for 6 month. Sample of 100 patients were taken from the perspective population. Data were collected by interviewing Tuberculosis patients using structured questionnaire. The result of the study showed that only 69 (69%) patient compliance to the treatment and 31 (31%) incompliance.

The result of analysis found 5 variables significantly to treatment compliance (p c 0,05). First younger more compliance than older with OR 2,78 (95%CI 1,10 - 6,05). Second, good knowledge compliance than low knowledge with OR 14,74 (95%C13,96 - 34,05). Third high education compliance with CR 7,31 (95%CI 7,65 - 20,28). Fourth closely distance, compliance with CR 3,20 (95%CI 1,32 - 1,75). Fifth family supported, compliance with OR 2,57 (95%CI 1,05 - 6,27).

The result of multivariate analysis with logistic regression method found 8 candidate variables of 10 independent variables and 2 variables statistically significant (p < 0,05), they are education with DR 7,31 (p = 0,000) and close distance with OR 3,20 (p = 0,0024). The analysis was controlling by the other variable, such as age, knowledge, job, sex, perception of service and family support. The study concluded that education and distance patient home have more contribution to treatment compliance of Tuberculosis disease in hospital than the other variables. Based on the result of the study, it is recommended to increase patients knowledge in Tuberculosis by health education, to increase patients compliance and make new Tuberculosis centre beside coordinate with health centre where is the patient live."

"MDR-TB menjadi masalah yang penting di Indonesia karena besarnya angka kematian dan morbiditas. Dengan mencari tahu alasan perkembangan tuberculosis menjadi MDR-TB, insidensi dari penyakit mematikan ini dapat dikurangi. Pengumpulan data dilakukan di RS Persahabatan dalam jangka waktu dari Desember 2009 sampai Agustus 2010 dan bertujuan untuk mengukur angka kepatuhan dalam pengobatan tuberculosis primer dan efek dari pembagian OAT secara gratis terhadap kepatuhan pasien. Pasien MDR-TB akan diwawancara secara retrospektif untuk mencari tahu derajat kepatuhan mereka saat pengobatan primer dulu. Hasil wawancara menunjukkan bahwa 46% dari pasien MDR-TB tidak mematuhi regimen pengobatan primer dulu. Angka ini jauh lebih buruk dari data tuberculosis pada umumnya. Hasil juga menyimpulkan bahwa hubungan antara pembagian obat secara gratis dan kepatuhan pasien sebagai non-signifikan.

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The problem of Multi-Drug Resistant Tuberculosis in Indonesia is of high importance due to its high mortality and morbidity rate. Finding clues as to how MDR-TB develops from susceptible strains of TB will help Indonesia in eliminating the menace that is MDR-TB. Data collection is done in RS Persahabatan, Jakarta during the period of December 2009 until August 2010, and aims to measure the rate of compliance in the primary TB treatment of confirmed MDR-TB patients. The study also looks at the effect of free medication on patient compliance. Interview sessions will be set for MDR-TB patients to look in retrospect towards their primary TB treatment. Results show that 46% of patients did not comply in their primary treatment, a lot higher than normal. It also proves of the relationship between compliance and the accessibility of free drugs to be non-significant."