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Sitompul, Jos Iswadi
"Gaya hidup masyarakat perkotaan saat ini cenderung kearah konsumsi makanan yang tidak sehat dan serba instan. Kehadiran makanan cepat saji, makanan berlemak, dan mengandung kolesterol yang tinggi dapat menyebabkan terjadinya kolelitiasis. Karya ilmiah akhir Nesr ini menggambarkan pemberian intervensi keperawatan berupa edukasi diet rendah lemak pada pasien dengan kolelitiasis. Perawat mempunyai peranan yang penting dalam meningkatkan pengetahuan klien untuk dapat memilih makanan yang tepat dan sehat. Pemberian pendidikan kesehatan ini diharapkan dapat meningkatkan pemahaman klien serta merubah perilaku kearah gaya hidup sehat.

Lifestyle of today?s urban society tends towards the consumption of unhealthy foods and almost instantaneous. The prensence of fast fod, fatty foods, and high cholesterol can lead to cholelithiasis. This papers describe the nursing implementations such as the provision of education low-fat diet in patiens with cholelithiasis. Nurses have an importan role in increasing knowledge of the clien to be able to choose the right foods and healthy. The provision of health education is expected to increase client understanding and changing behaviour towards a healthier lifestyle."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2014
PR-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Anindita Nazhifa
"Penelitian ini bertujuan untuk mengukur kualitas pola makan anak usia sekolah di SDN Pondok Cina 03 Depok dan perbedaan faktor-faktor yang berhubungan dengan kualitas pola makan. Penelitian ini menggunakan desain studi cross sectional. Kualitas pola makan diukur menggunakan modifikasi the Healthy Eating Index dengan rentang skor 0-100. Pengukuran asupan menggunakan 3x24 Hour Food Recall dan Status Gizi (IMT/U) dengan mengukur berat badan menggunakan timbangan digital dan tinggi badan menggunakan microtoice. Hasil penelitian menunjukkan lebih separoh responden (62.55%) memiliki kualitas pola makan kurang (skor HEI 51-80) dan 37.5% memiliki kualitas pola makan buruk (skor HEI <51). Rata-rata kualitas pola makan adalah 51.67±1.04. Terdapat perbedaan yang signifikan pada asupan energi, karbohidrat, lemak, lemak jenuh, porsi makanan pokok, lauk hewani, sayur, buah dan susu antar kelompok kualitas pola makan. Tidak terdapat perbedaan signifikan pada jenis kelamin, asupan protein, konsumsi nabati dan status gizi antar kelompok kualitas pola makan. Dapat disimpulkan bahwa kualitas pola makan siswa SDN Pondok Cina berkualitas kurang. Kualitas pola makan dapat diperbaiki dengan meningkatkan konsumsi makanan pokok, lauk hewani, sayur, buah dan susu. Disarankan kepada pihak sekolah untuk mengedukasi, mengawasi dan menyediakan kantin sehat. Kepada pihak orang tua untuk menyediakan makanan dan minuman sehat guna membentuk kualitas pola makan yang sehat.

The background of this study is to assess the overall diet quality among students at SDN Pondok Cina 03 Depok and to find the differences in associated factors between its category groups. The design of this study was cross sectional. Diet quality was assessed using the modification of healthy eating index. Dietary data was obtained using 3 days 24 hour food recall and nuritional status was measured by a digital scale and microtoice to get weight and height measurement. The results was more than half of praticipants (62.5%) had diet that “needs improvement” (HEI score 51-80) and others (32.7%) had diet that “poor” (HEI Score <51). The overall mean score of diet quality in this study was 51.67±1.04. Moreover, the overall diet quality catagories were significantly differences in intake of energy, carbohydrate, total fat and saturated fat, and serving size of grains, meat, vegetables, fruits, and milks. On the other hand there were no significant differences in intake of protein and serving size of beans between the groups. In conclusion, overall diet quality among fourth and fifth grade students was found to have diet that “needs improvement”. Increasing intake of grains, vegetables and fruits could improve the quality of overall diet. It is important for the school to monitor, educate, and provide healthy foods and drinks. Also for the parents to provide their children healthy foods and drinks at home so they can achieve the best quality on their overall diet.
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Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2015
S59147
UI - Skripsi Membership  Universitas Indonesia Library
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Aria Kekalih
"LATAR BELAKANG: Peningkatan jumlah ibu bekerja secara konsisten dapat berdampak positif meningkatkan status ekonomi rumah tangga, sebaliknya dapat berdampak negatif bagi pola asuh, asupan makanan serta pertumbuhan anak. Studi menganalisis praktik keragaman makanan (dietary diversity) sebagai komponen penting Makanan Pendamping ASI (MP-ASI) pada anak usia 6-23 bulan khususnya pada tiga tingkatan ibu bekerja: tenaga kerja/buruh tidak terampil, tenaga terlatih, tingkat professional dan ibu tidak bekerja sebagai pembanding. Studi juga menilai hubungan kondisi ibu bekerja dan keragaman makanan dalam menjelaskan mekanisme terjadinya stunting.
METODE: Kompilasi Survei Demografi Kesehatan Indonesia (SDKI) serta Riset Kesehatan Dasar (Riskesdas) periode tahun 2002 - 2012 digunakan untuk menganalisis ketepatan praktik konsumsi keragaman pangan pada anak serta determinannya. Sebagai studi kombinasi bertahap (sequential mixed method), hasil kuantitatif diperjelas kajiannya dengan studi kualitatif melalui wawancara mendalam kepada ibu dari berbagai tingkatan pekerjaan.
HASIL: Anak dengan keragaman makanan tepat yaitu minimum 4 jenis makanan dari usia 6 bulan hanya 18-24%, sedangkan selebihnya terlambat dikenalkan variasi makanan terutama sumber protein hewani. Ibu bekerja pada tingkat terendah (tenaga kerja tidak terampil) justru berhubungan dengan pola asupan yang kurang baik dan memburuknya stunting, padahal jumlahnya mencapai 40% dari ibu bekerja. Kesejahteraan rumah tangga, akses informasi, pelayanan kesehatan, pendidikan dan pekerjaan orang tua adalah faktor yang berasosiasi terhadap prilaku asupan yang baik. Studi kualitatif mendapatkan bahwa pada komunitas ibu bekerja sebagai buruh tidak terampil, tumbuh persepsi yang kompromi terhadap pemberian makanan seadanya karena keterbatasan sumber daya pengasuhan anak, disamping keharusan mereka untuk tetap bekerja memenuhi kebutuhan rumah tangga.
Analisis pathway mendapatkan bahwa ibu bekerja sebagai buruh tidak terampil secara langsung berhubungan dengan kurangnya keragaman makanan dan secara tidak langsung dengan stunting. Untuk menindaklanjuti kelompok ibu dan rumah tangga yang memerlukan intervensi edukasi, studi mengembangkan kuesioner skrining untuk mengidentifikasi rumah tangga yang tidak mampu memberikan keragaman makanan yang baik dengan akurasi 70% .
KESIMPULAN: Di Indonesia, banyaknya ibu bekerja sebagai tenaga kerja tidak terampil berpotensi memperburuk masalah stunting. Anak-anak usia 6-23 bulan mengalami masalah kurangnya dan terlambatnya diberikan keragaman makanan yang cukup. Penting untuk keluarga, terutama dengan ibu bekerja dengan anak masih dibawah 2 tahun, untuk meningkatkan kesadaran pengasuhan anak dan ketrampilan pemberian MP-ASI dengan keragaman pangan yang cukup sejak anak berusia 6 bulan, selain ASI eksklusif. Edukasi gizi dapat dilakukan tidak hanya kepada ibu, keluarga dan pengasuh anak, namun juga terhadap komunitas ibu bekerja dengan pemberdayaan program perusahaan sayang ibu dan bayi.

BACKGROUND: Consistent increasing number of working mothers can positively impact on household economy improvement, but otherwise may negatively affect parenting, child feeding and child growth. This study analyzed dietary diversity practice, as one important component of complementary feeding in children aged 6-23 months, and its determinants especially at the three levels of maternal occupation: unskilled labor, skilled labor, professional and also included non-working mother as reference. Study also analyzed direct and indirect association of maternal occupation and dietary diversity practices to explain mechanism of stunting.
METHODS: Compilation of Indonesian Demographic and Health Survey (IDHS) and the Basic Health Research (Riskesdas) from 2002 to 2012 were used to analyze the appropriateness of dietary diversity practice in children and its determinants. As sequential mixed method study, result of quantitative study were further explored by a qualitative study in the form of in-depth interviews
RESULTS: Children with timely minimum 4 food groups-dietary diversity (DD) since 6 months were only 18-24%, while the others had delayed introduce of animal source food. Mother worked at the lowest level (unskilled labor) lead to poorer dietary diversity and severe stunting, whilst their number was 40% of working mother. Household wealth, media exposure, access to health care, mother and father education and employment were factors associated to minimum DD. Qualitative studies found that unskilled labor mother community tend to compromise child feeding quality especially dietary diversity, due to limited child care resources, despite necessity to keep working to fulfill household needs. Pathway analysis found that mother working as unskilled labor directly caused poorer dietary diversity and indirectly caused stunting. To assess mother and household that required further education intervention related to DD importance, this study developed a scoring model for identifying household with high risk of inadequate dietary diversity with accuracy of 70%.
CONCLUSION: In Indonesia, the number of mothers who work as unskilled labor could potentially exacerbate the problem of stunting. Children aged 6-23 month old had inadequate and delayed timing for minimum dietary diversity in their diet. It is important for family, especially when the mother decided to work yet have under-two children, to re-develop parental awareness about the importance of complementary feeding with appropriate dietary diversity practice, beside exclusive breastfeeding. Nutrition education must not only be targeted to mother, family and caregiver, but also to working mother community via empowerment of mother and baby friendly company program.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
D-pdf
UI - Disertasi Membership  Universitas Indonesia Library
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Stephanie Yesica
"Tesis ini membahas program pemberian makanan tambahan berupa biskuit pabrikan bagi balita gizi kurang (pengukuran perbandingan berat badan menurut panjang atau tinggi badan balita) yang  telah dilakukan Pemerintah Indonesia sejak tahun 2004-2022. Pada praktiknya Pemberian Makanan Tambahan Pemulihan (PMT-P) berupa biskuit pabrikan juga diberikan bagi balita dengan berat badan kurang (pengukuran perbandingan berat badan menurut umur). Perlu adanya analisis untuk mengetahui hubungan pemberian makanan tambahan dengan Prevalensi Balita Berat Badan Kurang dan Gizi Kurang di Indonesia Tahun 2022. Penelitian ini merupakan studi kuantitatif dengan menggunakan data sekunder dengan desain cross-sectional. Data yang digunakan adalah Data Sekunder Sigizi Terpadu/EPPGBM dari Kementerian Kesehatan RI. Data  tersebut meliputi  jumlah balita penerima PMT-P dan balita dengan berat badan sangat kurang (severely underweight), berat badan kurang (underweight) dan gizi kurang (moderate wasted) seluruh provinsi di Indonesia tahun 2022. Hasil penelitian menunjukkan  ada hubungan antara pemberian makanan tambahan dengan prevalensi balita berat badan kurang (underweight) nilai P = 0,026 (CI = 0,007-0,101), sangat kurang (severely underweight) nilai P = 0,026 (CI = -0,101 s/d -0,007) dan gizi kurang (moderate wasted) nilai P = 0,021(CI = 0,056-0,650). Seluruh nilai P <0.005 menunjukkan ada hubungan prevalensi balita berat badan kurang dan gizi kurang. Penelitian menyarankan program pemberian makanan tambahan berupa biskuit dilanjutkan diikuti dengan program pendekatan keluarga bagi balita gizi kurang dan adanya penambahan pelaporan faktor determinan kejadian balita gizi kurang di aplikasi EPPGBM.

This thesis discusses the supplementary feeding program in the form of manufactured biscuits for malnourished toddlers (measurement of the ratio of body weight according to the length or height of toddlers) that has been carried out by the Government of Indonesia from 2004-2022. In practice, supplementary feeding in the form of manufactured biscuits is also given to toddlers with underweight (a measure of the ratio of body weight to age). An analysis is needed to determine the relationship between supplementary feeding and the Prevalence of Underweight and Malnourished Children in Indonesia in 2022. This research is a quantitative study using secondary data with a cross-sectional design. The data used is Integrated Nutrition Secondary Data / EPPGBM from the Indonesian Ministry of Health. The data includes the number of toddlers receiving PMT-P and severely underweight, underweight and wasted toddlers in all provinces in Indonesia in 2022. The results show that there is a relationship between supplementary feeding and prevalence of underweight toddlers P value = 0.026 (CI = 0.007-0.101), severely underweight P value = 0.026 (CI = -0.101 to -0.007) and moderate wasted P value = 0.021(CI = 0.056-0.650). All P values <0.005 indicated that there was a relationship between the prevalence of underweight and malnutrition. The research suggested that the supplementary feeding program in the form of biscuits be continued followed by a family approach program for undernourished toddlers and additional reporting of the determinants of the incidence of undernourished toddlers in the EPPGM application."
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2023
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UI - Tesis Membership  Universitas Indonesia Library
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Arif Ridwan
"Hipertensi merupakan salah satu masalah kesehatan yang terjadi di perkotaan pada lansia sebagai populasi yang rentan (vulnerable) karena salah satu faktor risiko yaitu pola diet. Penelitian ini dilakukan bertujuan untuk menggambarkan hasil asuhan keperawatan pada lansia hipertensi dengan intervensi keperawatan pengaturan menu diet DASH (Dietary Approaches to Stop Hypertension). Metode penelitian yang digunakan adalah praktik lapangan. Hasil yang didapatkan adalah terjadi penurunan tekanan darah selama proses intervensi dilakukan. Penelitian ini merekomendasikan pengaturan diet DASH sebagai salah satu cara untuk mengontrol dan menurunkan tekanan darah pada lansia.

Hypertension is one of the health problems that occur in the elderly as a vulnerable population at urban areas because of dietary patterns as risk factor. The purpose of this study is to describe the nursing care outcomes in older adult with hypertension using nursing intervention settings of DASH diet (Dietary Approaches to Stop Hypertension). The method used was practice field. The results obtained were a decreased in blood pressure during the intervention process. This study reccomended DASH diet as a way to control and lower blood pressure in the elderly.
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Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2014
PR-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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"Long-term health benefits can be achieved by vegetarian including a lower risk of
cardiovascular disease, some fomms of cancer, and hypertension. Some vegetarians
worry, that they're not getting enough nutrients when they are pregnant. In fact,
there is nothing to be worried about. Pregnant vegetarian could meet good
nutritional status by knowing key nutrients they should eat. Key nutrients for
vegetarian pregnancy include protein, iron, zinc, calcium, vitamin D, vitamin B12,
iodine, and omega-3 fatty acids. A vegetarian or vegan diet can meet requirements
for all of these nutrients although in some instances, fortified foods or supplements
can be especially useful in meeting recommendations. The nutrient content of
supplements targeted to pregnant vegetarians should be evaluated to make sure
nutrient needs are being met. Other important aspect concerning vegetarian diet is
gestational weight gain. Optimal birth weight and outcome are influenced by maternal
weight gain. Low gestational weight gain is associated with poor fetal growth and
risk of pretemi delivery while excessive weight gain affects infant growth, body
fatness in childhood, and the potential for postpartum weight retention and future
obesity. Vegetarian women should also be counseled to follow standard weight gain
recommendations. Ideally, weight gain recommendations should be individualized to
promote the best outcomes while reducing risk for excessive postpartum weight
retention and reducing the risk of later chronic disease for the child and adult. Some
studies (Rosso, 1985; Umniyati, 2009) stated an optimal weight gain for pregnancy
outcome is 20% of ideal matemal weight. In order to calculate a recommendation of
optimal weight gain to be achieved by pregnant mothers, pre-pregnancy weight
should be known. By understanding these aspects, optimal weight gain and
important nutrients needs, vegetarian pregnant mother can get optimal pregnancy
outcomes."
[FKM UI, Universitas Indonesia], 2009
MK-Pdf
UI - Makalah dan Kertas Kerja  Universitas Indonesia Library
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Zuraidah Hanifah
"Konsumsi sayur dan buah masyarakat Indonesia masih jauh dari kategori cukup. Remaja ditemukan sebagai kelompok umur dengan persentase tertingi untuk konsumsi sayur dan buah yang kurang. Konsumsi sayur dan buah yang kurang pada saat remaja akan mempengaruhi status kesehatan di masa mendatang. Penelitian ini bertujuan untuk mengetahui faktor dominan yang berhubungan dengan konsumsi sayur dan buah pada kelompok remaja di Jakarta. Penelitian ini menggunakan disain cross sectional pada bulan April hingga Mei 2018 di SMAN 39 Jakarta. Responden terdiri dari siswa kelas X dan kelas XI. Pengambilan data menggunakan kuesioner dan FFQ dengan metode angket.
Hasil penelitian ini menunjukkan bahwa terdapat 68,4 responden termasuk ke dalam kategori kurang konsumsi sayur dan buah. Uji chi square yang dilakukan menghasilkan bahwa terdapat hubungan antara pengaruh orangtua OR=2,436; CI=1,293-4,587 dan keterlibatan dalam berbelanja OR=2,045; CI=1,091-3,834 dengan konsumsi sayur dan buah pada responden. Analisis lebih lanjut berupa analisis multivariat dengan uji regresi logistic ganda menunjukkan hasil bahwa pengaruh orangtua menjadi faktor dominan yang berhubungan dengan konsumsi sayur dan buah pada siswa.

Consumption of vegetables and fruits of Indonesian society is still far from sufficient category. Adolescents are found as the age group with the highest percentage for less vegetable and fruit consumption. Consumption of less vegetables and fruits during adolescence will affect health status in the future. This study aims to determine the dominant factors associated with consumption of vegetables and fruits in groups of adolescents in Jakarta. This study used cross sectional design in April to May 2018 at SMAN 39 Jakarta. Respondents consisted of students of class X and class XI. Data collection using self administered questionnaire and.
The results of this study indicate that there are 68.4 of respondents included into the category of less consumption of vegetables and fruits. The chi square test performed resulted in a relationship between parental influence OR 2,436 CI 1,293 4,587 and shopping involvement OR 2,045 CI 1,091 3,834 with consumption of vegetables and fruits in the respondents. Further analysis in the form of multivariate analysis with multiple logistic regression test showed that the influence of parents became the dominant factor related to the consumption of vegetables and fruit in the students.
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Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2018
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UI - Skripsi Membership  Universitas Indonesia Library
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Rini Fauzia Astuti
"Semakin bertambahnya jumlah penduduk semakin bertambah pula masalah terkait kesehatan, terutama di wilayah perkotaan yang pertambahan penduduknya setiap tahun meningkat. Karya Ilmiah Akhir ini memberikan gambaran mengenai asuhan keperawatan keluarga pada keluarga Ibu A dengan masalah ketidakefektifan pemeliharaan kesehatan pada lansia. Implementasi yang telah dilakukan bersifat kognitif, afektif, dan psikomotor. Implementasi yang lebih efektif mengontrol tekanan darah lansia yaitu diet rendah garam. Hasil evaluasi setelah kunjungan selama enam minggu yaitu tekanan darah pada Nenek K mengalami penurunan 30 mmHg pada tekanan darah sistolik dan 10 mmHg pada tekanan darah diastolik. Pemberdayaan keluarga dan kader penting dalam merawat lansia dengan hipertensi.

Increasing number of the population also has made increasing problems about healthy, especially in urban area where the population increasing every year. This final assignment describes about nursing care process at Mrs. A’s family with ineffectiveness of health care in elderly. Implementation has been done are cognitive, affective, and psychomotor. Implementation more effective to control blood pressure in elderly is low-salt diet. The result of the evaluation after six weeks visit was blood pressure at Mrs. K has decreased 30 mmHg for systolic blood pressure and 10 mmHg for diastolic blood pressure. Empowerment family and cadre are important to caring elderly with hypertension.
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Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2014
PR-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Farisa Milla Shabrina
"Kalsium merupakan zat gizi yang berperan penting dalam pertumbuhan. Skripsi ini bertujuan untuk mengetahui perbedaan asupan kalsium berdasarkan frekuensi konsumsi susu, frekuensi konsumsi sumber kalsium lain, preferensi rasa susu, kebiasaan sarapan, aktivitas fisik, jenis kelamin, pengetahuan mengenai kalsium, dan uang saku. Desain penelitian yang digunakan adalah cross sectional dan dilakukan pada 120 siswa SMP Islam PB Soedirman Jakarta Timur selama bulan April 2016. Pengumpulan data dilakukan melalui pengisian kuesioner dan asupan kalsium diukur dengan wawancara food recall 2x24 jam. Data dianalisis dengan menggunakan uji t-test independent.
Hasil penelitian ini menunjukkan 46% memiliki asupan kalsium kurang dengan rata-rata asupan kalsium 428± 340,3 mg. Analisis bivariat menunjukkan terdapat perbedaan asupan kalsium yang signifikan berdasarkan frekuensi konsumsi susu, preferensi rasa susu, jenis kelamin, dan pengetahuan mengenai kalsium.

Calcium plays a central role in human's growth. This research aims to explore and determine the differences of calcium intake based on milk consumption frequency, other calcium-rich foods sources frequency, milk-taste preferences, breakfast habit, physical activity, sex, calcium-related knowledge, and pocket money. This research adapts cross-sectional design with a total of 120 students of PB Soedirman Islamic Junior High School in West Jakarta during April 2016. Data was collected using questionnaire and food recall (2x24 hours) method to measure calcium intake. The data was analyzed using t-test independent test.
The results showed that 46% of the students had calcium intake below 924 mg/day and the average calcium intake was 428±340.3 mg. Bivariate analysis results showed significant mean-difference of calcium intake based on milk consumption frequency, milk taste preference, sex, and calcium-related knowledge.
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Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2016
S65433
UI - Skripsi Membership  Universitas Indonesia Library
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Audina Khalda Nabilah
"PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) merupakan regulator Low-Density Lipoprotein (LDL) melalui perannya dalam degradasi Low-Density Lipoprotein Receptor (LDLR) sehingga PCSK9 dapat dijadikan target terapi yang menjanjikan sebagai agen penurun lipid. Inhibitor PCSK9 yang tersedia memiliki beberapa kekurangan. Untuk itu, banyak peneliti mengembangkan obat inhibitor PCSK9 lainnya. Dalam pengembangan obat, model hewan PCSK9 yang sejalan pada manusia dibutuhkan dan dikembangkan melalui induksi suatu nutrisi, misalnya fruktosa. Penelitian efek diet tinggi fruktosa terhadap kadar PCSK9 plasma dan ekspresi PCSK9 otak masih sangat terbatas dan perlu diteliti lebih lanjut. Pada penelitian ini, tikus diberikan diet tinggi fruktosa dengan variasi durasi, yaitu 3 minggu, 4 minggu, dan 5 minggu untuk melihat efeknya terhadap kadar PCSK9 dan ekspresi PCSK9. Pengukuran kadar PCSK9 plasma dan otak dilakukan menggunakan metode ELISA dan ekspresi PCSK9 otak dianalisis menggunakan metode western blot. Hasil menunjukkan bahwa terjadi perubahan kadar PCSK9 pada plasma dan otak tikus dibandingkan kelompok normal. Kadar PCSK9 plasma menunjukkan peningkatan signifikan (p<0,05) pada kelompok 3 minggu dan 4 minggu dibandingkan kelompok kontrol dan kadar PCSK9 plasma tertinggi teramati pada durasi induksi 4 minggu. Kadar PCSK9 otak menunjukkan penurunan signifikan (p<0,05) pada kelompok 3 minggu dan 4 minggu dibandingkan kelompok kontrol. Ekspresi PCSK9 pada otak menunjukkan pola penurunan dibandingkan dengan kelompok kontrol. Berdasarkan hasil, dapat disimpulkan bahwa model hewan PCSK9 pada tikus berpotensi digunakan sebagai model hewan PCSK9.

PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) is a Low-Density Lipoprotein (LDL) regulator through its role in Low-Density Lipoprotein Receptor (LDLR) degradation, making PCSK9 a promising therapeutic target as a lipid-lowering agent. The currently available PCSK9 inhibitors have drawbacks. As a result, many researchers have developed PCSK9 other inhibitor drugs. PCSK9 animal model is required in drug development and develops through the induction of a nutrient, such as fructose. Research on the effect of a high-fructose diet on circulating PCSK9 levels and brain PCSK9 expression is still limited dan further research is needed. Thus, in this study, rats were fed a high-fructose diet for 3 weeks, 4 weeks, and 5 weeks to see how it affected PCSK9 levels and expression. The ELISA method was used to measure plasma and brain PCSK9 levels and the western blot method was used to analyze brain PCSK9 expression. The results showed plasma PCSK9 levels increased significantly (p<0,05) in the 3-week and 4-week groups compared to the control group, with the 4-week induction duration producing the highest plasma PCSK9 levels. Brain PCSK9 levels decreased significantly (p<0,05) in the 3-week and 4-week groups when compared to the control group. PCSK9 expression in the brain also decreased when compared to the control group. Based on the findings, the PCSK9 animal model in rats has the potential to be used as a PCSK9 animal model."
Depok: Fakultas Farmasi Universitas Indonesia, 2023
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
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