Hasil Pencarian  ::  Simpan CSV :: Kembali

""Kaplan and Pesce's Clinical Chemistry: Theory, Analysis, Correlation, Fifth Edition is a comprehensive, readable text that is designed for clinical laboratory science students but also works as a great resource for practitioners and pathology residents. You'll stay up-to-date with new information and revised sections reflecting recent advances in the field. The test is divided into two parts ensuring that you'll learn about all areas of clinical chemistry. Part 1 focuses on Laboratory Techniques and Laboratory Management whereas Part 2, Physiology and Pathophysiology, provides descriptions of how specific diseases affect the human body. The text provides chapter outlines, key terms, key concepts, and section objectives to aid students with studying."--BOOK JACKET."

"Osteosarkoma merupakan salah satu tumor ganas tulang primer yang paling sering ditemukan. Kemoterapi neoadjuvan merupakan salah satu alternatif terapi yang dapat meningkatan luaran dan kesintasan pasien. Studi ini dilakukan untuk menilai luaran klinis, histopatologis, dan radiologis pada pasien osteosarkoma yang menjalani kemoterapi neoadjuvan beserta faktor-faktor yang mempengaruhinya. Penelitian ini merupakan suatu studi potong lintang yang menggunakan data pasien dengan diagnosis osteosarkoma yang telah menjalani kemoterapi neoadjuvan di RSUPN dr. Cipto Mangunkusumo pada bulan Januari 2017 hinggal Juli 2019. Terdapat 58 subjek dalam penelitian ini. Sebanyak 38 (65,5%) subjek berjenis kelamin laki-laki dengan median usia seluruh subjek 16 (5 hingga 67) tahun. Sebanyak 10 (17,2%) subjek merupakan good responder kemoterapi neoadjuvan. Dari hasil analisis data didaapatkan perbedaan bermakna kadar laboratoris ALP (p=0,002), LED (p=0,002), dan NLR (p<0,001) sebelum dan sesudah kemoterapi. Derajat nekrosis berkorelasi negatif dengan perubahan nilai LDH sebelum dan sesudah kemoterapi (r=-0,354; p=0,006), namun tidak didapatkan hubungan yang bermakna dengan parameter lain seperti perubahan kadar ALP (r=-0,186; p=0,162) dan LED (r=-0,104;  p=0,437). Secara radiologis didapatkan peningkatan nilai ADC yang bermakna (p=0,028) setelah pemberian kemoterapi neoadjuvan, namun perubahannya tidak berhubungan dengan persentase nekrosis tumor (r=-0,300; p=0,433). Pada pasien osteosarkoma yang menjalani kemoterapi neoadjuvan di RSUPN dr. Cipto Mangunkusumo bulan Januari 2017 hingga Juli 2019, didapatkan perbedaan bermakna kadar penanda inflamasi dan parameter radiologis berupa ADC sebelum dan sesudah pemberian kemoterapi adjuvan.

---

Osteosarcoma is one of the most prevalent primary tumors of the bone. Neoadjuvant chemotherapy has been administered in osteosarcoma cases to increase the survival rate and improve outcomes. This study is conducted to investigate the clinical, histopathological, and radiological outcome of osteosarcoma patients who underwent neoadjuvant chemotherapy, as well as the various factors that contributes to said outcome. This study is a cross-sectional study that involves the data of patients diagnosed with osteosarcoma who underwent neoadjuvant chemotherapy in RSUPN dr. Cipto Mangunkusumo from January 2017 up to July2019. A total of 58 subjects was admitted in this study. Thirty-eight (65,5%) subjects are male, with the median age of all subjects being 16 years old (5 to 67). We found that 10 subjects (17,2%) is a good responder to neoadjuvant chemotherapy. From the data analysis, significant differences were observed in ALP (p=0,002), ESR (p=0,002) and NLR (p=<0,001) levels before and after neoadjuvant chemotherapy. The degree of necrosis is inversely correlated with the change in LDH level before and after neoadjuvant chemotherapy (r=-0,354; p=0,006), however, no significant correlation was observed in ALP (r=-0,186; p=0,162) dan ESR (r=-0,104;  p=0,437). Radiologically, there is an increase in ADC value (p=0,028) after neoadjuvant chemotherapy. However, this is not correlated with the degree of necrosis (r=-0,300; p=0,433) observed pathologically. There is a significant difference in inflammatory markers and radiological parameter (ADC) pre and post neoadjuvant chemotherapy among osteosarcoma patients in RSUPN dr. Cipto Mangunkusumo from January 2017 up to July 2019."

"Penelitian telah menunjukkan pentingnya jaringan berkeratin di sekitar implan untuk mencegah penyakit peri-implan. Penelitian ini bertujuan untuk menganalisis hubungan mukosa-gingiva berkeratin di sekitar implan dan gigi dengan skor parameter klinis dan kadar TNF-α. Sebuah studi potong lintang dari 20 orang dewasa dengan 20 implan gigi dan 20 gigi kontralateral yang telah berfungsi supra-struktur selama lebih dari tiga bulan, tanpa penyakit sistemik. Jaringan keratin di sekitar implan dan gigi diukur. Pemeriksaan klinis meliputi Plaque Index (PI), Papilla Bleeding Index (PBI), dan Pocket Depth (PD). Peri-implant Sulcus Fluid (PISF) dan Gingival Crevicular Fluid (GCF) dikumpulkan untuk mengukur kadar TNF-α menggunakan ELISA. Uji Spearman digunakan untuk menganalisis korelasi. Perbedaan signifikan antara jaringan keratin lebar dan sempit di sekitar implan terlihat pada PI (p=0,003), PBI (p=0,000), dan PD (p=0,004), tetapi tidak menunjukkan perbedaan pada kadar TNF-α (p=0,606). Perbandingan antara jaringan berkeratin lebar dan sempit di sekitar gigi kontralateral menunjukkan perbedaan pada PI (p=0,020) dan PBI (p=0,027), tetapi tidak ada perbedaan pada PD (p=0,160) dan kadar TNF-α (0,236). Tidak ada perbedaan skor parameter klinis dan kadar TNF-α antara gigi implan dan kontralateral dengan jaringan berkeratin lebar atau sempit. Korelasi kuat ditemukan antara setiap skor parameter klinis dan lebar jaringan keratin dari jaringan peri-implan dengan PI (r=-0,630), PBI (r=-0,881), dan PD (r=-0,636). Skor parameter klinis antara jaringan berkeratin lebar dan sempit di sekitar implan menunjukkan korelasi yang kuat terutama pada PBI. Hal ini menyimpulkan pentingnya jaringan keratin yang memadai di sekitar implan untuk menjaga stabilitas implan.

---

Studies have shown the importance of keratinized tissue around implant to prevent peri-implant diseases. This study aims to analyze the correlation of keratinized tissue around implant and tooth with clinical parameter scores and TNF-α levels. A cross-sectional study of 20 adults with 20 dental implants and 20 contralateral teeth which had functioned supra-structure for more than three months, without any systemic diseases. Keratinized tissue around implant and tooth were measured. The clinical examinations included Plaque Index (PI), Papilla Bleeding Index (PBI), and Pocket Depth (PD). Peri-implant Sulcus Fluid (PISF) and Gingival Crevicular Fluid (GCF) were collected to measure TNF-α levels using ELISA. Spearman’s test was used to analyse the correlation. Significant differences between wide and narrow keratinized tissue around implant exhibit in PI (p=0.003), PBI (p=0.000), and PD (p=0.004), but showed no difference in TNF-α levels (p=0.606). Comparison between wide and narrow keratinized tissue around contralateral teeth showed differences in PI (p=0.020) and PBI (p=0.027), but there was no difference in PD (p=0.160) and TNF-α levels (0.236). There was also no difference in clinical parameter scores and TNF-α levels between the implant and contralateral tooth with wide or narrow keratinized tissue. Strong correlations were found between each clinical parameter score and keratinized tissue width of peri-implant tissue with PI (r=-0.630), PBI (r=-0.881), and PD (r=-0.636). Clinical parameters score between wide and narrow keratinized tissue around implant showed strong correlation particularly in PBI. This concludes the importance of adequate keratinized tissue around implant to maintain implant stability. "

"This richly illustrated book presents a straightforward non-instrumental method of clinical facial analysis in preparation for aesthetic surgery, orthognathic surgery, and orthodontic treatments. After discussion of various practical aspects of facial examination and photography, analysis of different regions of the face and dentofacial deformities is discussed in a series of detailed chapters. At the end of each of these chapters, multiple-choice checklists are included that will help the reader to perform step-by-step regional analysis. Important features of the book are its multidisciplinary approach and the emphasis placed on the relationship between different parts of the face. This second edition has been thoroughly updated and includes a new chapter on recording and documentation relating specifically to aesthetic facial surgery."