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Azma Rosida
Gambaran Immature Reticulocyte Fraction dan status Besi pada remaja putri setelah suplementasi Besi oral = Profile of Immature Raticulocyte Fraction and Iron status within girls post Iron supplementation per oral
"Defisiensi besi merupakan keadaan dimana jumlah total besi tubuh berkurang yang bila berlanjut menyebabkan anemia defisiensi besi. Saat ini tersedia parameter immature reticulocyte fraction (IRF) yang menunjukkan fraksi retikulosit muda di sirkulasi yang bermanfaat menilai aktivitas eritropoiesis. Tujuan penelitian ini untuk mengetahui korelasi IRF dengan kadar besi dan feritin serum, dan saturasi transferin, serta korelasi feritin dan hepsidin serum. Penelitian dengan desain penelitian potong lintang ini melibatkan 77 subyek remaja putri sekolah yang telah haid dan mendapat suplementasi besi oral 2 kali seminggu selama 12 minggu. Dilakukan pemeriksaan kadar hemoglobin, hitung retikulosit absolut, IRF, kadar besi, feritin, dan hepsidin serum serta saturasi transferin. Didapatkan korelasi bermakna dengan kekuatan sedang antara IRF dan kadar besi dan feritin serum, serta saturasi transferin (berturut-turut p<0,0001, r = -0,443; p = <0,0001, r = -0,439, dan p<0,0001, r = -0,423), dan antara kadar feritin dan hepsidin serum (p<0,001, r = 0,371). Dapat disimpulkan bahwa IRF memiliki hubungan bermakna dengan status besi tubuh.
Decreased total body iron will cause iron deficiency, which could end up to iron deficiency anemia. Currently, immature reticulocyte fraction (IRF) was introduced as a parameter to show young reticulocyte fraction in the circulation, as a useful tool to evaluate erythropoiesis activity. The aim of this study was to investigate the correlation between IRF with serum iron and ferritin concentrations, and with transferin saturation, and between serum ferritin with hepcidin concentration. A cross sectional study was conducted in Pramuka island involving 77 post-menarchal adolescent school girls, who had received twice weekly iron supplementation for 12 weeks. Serum concentrations of iron, ferritin, and hepsidin, haemoglobin concentration, transferin saturation, absolute reticulocyte count, and IRF were determined. There were significance correlations between IRF with serum iron and ferritin, concentrations, and with transferin saturation (p<0.0001, r = - 0.443; p<0.0001, r = -0.439 ; and p = <0.0001, r = -0.423, respectively), and between serum hepsidin and ferritin concentrations (p<0.001, r = 0.371). It can be concluded that IRF had significant correlation with iron status."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Ni Putu Veny Kartika Yantie
Peran prostaglandin E2, vascular endothelial growth factor immature platelet fraction dan efek pemberian ibuprofen oral pada duktus arteriosus paten neonatus cukup bulan = The Role of prostaglandin vascular endothelial growth factor immature platelet fraction and efficacy of oral ibuprofen in patent ductus arteriosus of full term neonates
"Latar belakang: Morbiditas akibat duktus arteriosus paten (DAP) pada neonatus cukup bulan (NCB) cukup tinggi. Peran prostaglandin E2 (PGE2), trombosit (immature platelet fraction, IPF), dan vascular endothelial growth factor (VEGF) pada penutupan DA secara fungsional dan anatomis pada NCB belum banyak diteliti. Patofisiologi terjadinya DAP dapat memengaruhi tata laksana farmakologi dini yang belum terstandardisasi pada NCB. Penggunaan obat antiinflamasi nonsteroid seperti ibuprofen dimungkinkan dapat menghambat jalur sintesis prostaglandin dengan efek samping minimal.
Tujuan: Mengkaji peran prostaglandin E2, VEGF, IPF, dan efek pemberian ibuprofen oral dalam proses penutupan DA pada NCB.
Metode: Penelitian dilakukan di rumah sakit (RS) Sanglah Denpasar, RS Prima Medika Denpasar, dan RS Umum Daerah Wangaya Denpasar, dalam periode Maret sampai Agustus 2015. Penelitian terdiri dari 2 desain, pertama desain potong lintang pada pasien dengan DAP dan tanpa DAP secara consecutive sampling dan desain kedua uji klinis acak terkontrol ganda pada pasien DAP usia ≥ 48 jam. Pasien dengan DAP kemudian dimasukkan dalam uji klinis, dilakukan randomisasi untuk diberikan perlakuan ibuprofen oral dosis hari pertama 10 mg/kg, hari kedua dan ketiga 5 mg/kg atau plasebo. Pemantauan hemodinamik dan efek samping obat dilakukan selama pemberian perlakuan. Pemeriksaan ekokardiografi, PGE2, VEGF, IPF, dan kreatinin dilakukan pada hari pertama dan keempat pascapemberian perlakuan.
Hasil: Terdapat 64 subjek yang diteliti pada desain pertama dan 32 subjek pada desain kedua. Rerata kadar PGE2 lebih tinggi pada kelompok dengan DAP dibanding tanpa DAP, sedangkan rerata kadar VEGF dan IPF tidak berbeda. Ibuprofen oral tidak terbukti menurunkan diameter DA pascaperlakuan, tidak terdapat perbedaan rerata diameter pada kedua kelompok. Terdapat hubungan positif sedang terhadap perubahan kadar PGE2 dengan perubahan diameter DAP pascaperlakuan. Tidak terdapat perubahan hemodinamik atau efek samping akibat pemberian ibuprofen oral atau plasebo pada NCB dengan DAP.
Simpulan: Tingginya kadar PGE2 terbukti berperan dalam patensi DA pada NCB. Ibuprofen oral dosis 10 - 5 - 5 mg/kgBB tidak mengecilkan diameter DAP.
Background: Serious morbidity impact due to patent ductus arteriosus (PDA) in full-term neonates remains high. The functional role of prostaglandin E2 (PGE2), platelet (immature platelet fraction, IPF), and vascular endothelial growth factor (VEGF) has not been studied in the closure mechanism of ductus arteriosus (DA). Understanding of pathophysiology of PDA may influence early pharmacological treatments, which have not been standardized in full-term neonates. The use of non-steroidal anti-inflammatory drugs such as ibuprofen can be beneficial as a pharmacological agent in enhancing the closure of PDA with minimal adverse effects.
Objectives: To evaluate the role of prostaglandin E2, VEGF, IPF, and the effect of oral ibuprofen in the process of DA closure in full-term neonates.
Methods: This study was conducted in Sanglah General Hospital, Prima Medika Hospital, and Wangaya Hospital Denpasar. The study consisted of two designs, the first was cross-sectional design in subjects with and without PDA using consecutive sampling and the second was double blind randomized controlled trial in full-term infant aged ≥ 48 hours. Subjects with PDA were randomized to oral ibuprofen and placebo administration, in which ibuprofen was given consecutively 10 - 5 - 5 mg/kg. All subjects underwent echocardiography, PGE2, VEGF, and IPF assays. Hemodynamics monitoring was evaluated during trial and adverse effect due to ibuprofen was recorded by measuring urine volume and plasma creatinine level.
Results: From March to August 2015, there were 64 subjects recruited for the first design and 32 subjects in the second design. The mean level of PGE2 was higher significantly in the group with PDA than non PDA group, while the mean levels of VEGF and IPF showed no difference. In the second design, oral ibuprofen showed no effect in reducing DA diameter after treatment. There were no differences in mean diameter of DA in both groups before and after treatments. There was moderate positive relationship between levels of PGE2 and the change of PDA diameter. There were neither hemodynamic changes nor adverse effect due to the administration of oral ibuprofen or placebo.
Conclusions: A high level of PGE2 appears to play a pivotal role in DA patency of full-term neonates. Administration of oral ibuprofen in 10 - 5 - 5 mg/kg schedule could not induce PDA closure in full-term neonates."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Disertasi Membership  Universitas Indonesia Library
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Eka Siyanti Sumarlan
Status besi, prevalens, dan faktor risiko anemia defisiensi besi pada remaja perempuan usia 12-15 tahun di Sekolah Menengah Pertama di Jakarta Pusat = Iron status, prevalence, and risk factors of iron deficiency anemia in 12 to 15-year old adolescents girls in Junior High School in Central Jakarta
"Latar Belakang: Anemia defisiensi besi (ADB) merupakan jenis anemia yang tersering pada remaja. Dampak defisiensi besi mulai dari berkurangnya kemampuan kerja fisis hingga gangguan fungsi kognitif. Pada saat memasuki kehamilan, ADB dapat meningkatkan mortalitas dan morbiditas pada ibu maupun pada bayi. Faktor risiko ADB pada remaja multifaktorial.
Tujuan: Mengetahui status besi, prevalens dan faktor risiko ADB pada remaja perempuan usia 12-15 tahun di Jakarta Pusat.
Metode: Studi potong lintang pada remaja perempuan usia 12-15 tahun di Sekolah Menengah Pertama (SMP). Subjek dibagi menjadi kelompok status sosial ekonomi (SSE) menengah-keatas dan menengah-kebawah. Pada subjek dinilai status gizi, status dan karakteristik menstruasi, pekerjaan, pendidikan, dan penghasilan orangtua, serta asupan besi. Pada subjek juga dilakukan pemeriksaan laboratorium hematologis, biokimia besi, dan (C-reactive protein) CRP. Uji tuberkulin dilakukan untuk menyingkirkan APK akibat tuberkulosis, penyakit kronik tersering di Indonesia.
Hasil: Diantara 163 subjek, prevalens status besi normal sebesar 69,3%. Prevalens defisiensi besi non anemia lebih tinggi (17,2%, berupa deplesi (3,1%) dan defisiensi besi (14,1%) dibandingkan prevalens ADB (13,5%). Prevalens ADB pada kelompok status sosial ekonomi (SSE) menengah-keatas lebih rendah daripada SSE menengah-kebawah (11,5% dan 15,8%). Tidak didapatkan hubungan yang bermakna antara prevalens ADB dengan status gizi, status dan karakteristik menstruasi, SSE, dan pendidikan maupun penghasilan orangtua. Asupan besi bioavailable pada seluruh subjek kurang dari angka kecukupan gizi (AKG), namun tidak didapatkan hubungan yang bermakna dengan prevalens ADB.
Simpulan: Prevalens deplesi dan defisiensi besi yang lebih tinggi dari prevalens ADB berpotensi meningkatkan prevalens ADB pada masa mendatang. Meskipun tidak didapatkan hubungan yang bermakna antara prevalens ADB dengan faktor risikonya, namun asupan besi yang kurang dari AKG pada seluruh subjek perlu diperhatikan. Suplementasi besi sesuai rekomendasi Ikatan Dokter Anak Indonesia perlu dilaksanakan dalam upaya pencegahan dan penanggulan defisiensi besi pada remaja.
Background: Iron deficiency anemia (IDA) is the most common anemia in adolescents. Iron deficiency cause decreased physical performance as well as cognitive impairment. In pregnancy, IDA increases maternal and fetal mortality and morbidity. Risk factors of IDA in adolescents are multifactorials.
Objectives: To identify iron status, prevalence dan risk factors of IDA in 12 to 15-year old adolescents girls in Central Jakarta.
Methods: Cross-sectional study in 12 to 15-year old adolescent girls who study in Junior High School. Subjects were classified into higher and lower social economy status (SES). Assessment of nutritional status, menstruation status and characteristics, occupation, parents education level and income, as well as iron intake. Subjects were undergo supporting examinations, such as hematological, iron parameters and C-reactive protein (CRP). Tuberculin test was done to rule out anemia of chronic disease due to tuberculosis, the most common chronic disease in Indonesia.
Results: Out of 163 subjects, prevalence of normal iron status was 69,3%. Non anemia iron deficiency prevalence was higher (17,2%, consists of 3,1% iron depletion and 14,1% iron deficiency) than IDA prevalence (13,5%). Prevalence of IDA in higher SES was lower than that in lower SES (11,5% and 15,8%). There was no significant association betwen prevalence of IDA and nutritional status, menstruation status and characteristics, SES, as well as parents’ education level and income. Bioavailable iron intake in all subjects was less than RDA, no significant association betwen bioavailable iron intake and IDA prevalence.
Conclusions: Non anemic iron deficiency prevalence that was higher than prevalence of IDA is potensial to increase prevalence of IDA in the future. Altough there is no significant association betwen IDA and its risk factors, iron intake that is less than RDA in all subjects requires more attention. Iron supplementation based on Indonesian Pediatric Society need to be reinforced to prevent and overcome iron deficiency in adolescent."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
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UI - Tugas Akhir  Universitas Indonesia Library
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Melita Adiwidjaja
Nilai batasan reticulocyte hemoglobin equivalent untuk skrining status besi pada anak usia 6 sampai 18 tahun = Cut-off value of reticulocyte haemoglobin equivalent for iron status screening among children aged 6 until 18 years old
"Defisiensi besi adalah defisiensi mikronutrien yang paling sering ditemui. Jika tidak diobati, dapat menyebabkan anemia defisiensi besi dan gangguan kognitif, terutama pada anak usia sekolah, yang ireversibel. Diagnosis defisiensi besi rumit, tidak praktis, dan mahal. Organisasi AAP merekomendasikan RET-He sebagai pemeriksaan laboratorium untuk skrining defisiensi besi. Tujuan penelitian adalah untuk mencari nilai batasan RET-He untuk skrining status besi pada anak usia 6 – 18 tahun. Studi ini merupakan studi potong lintang terhadap 207 anak sehat usia 6 - 18 tahun di Indonesia. Penelitian ini mencari nilai batasan RET-He untuk skrining status besi, kemudian dibandingkan dengan hemoglobin, mean corpuscular volume, feritin, dan saturasi transferin. Kurva ROC dikerjakan untuk menentukan nilai batasan RET-He untuk skrining status besi dengan menggunakan IBM SPSS versi 22. Pemeriksaan RET-He mendapatkan nilai batasan ≤ 30,3 pg (sensitivitas 100%, spesifisitas 19,7%, NDN 100%, NDP 5,4%) untuk skrining deplesi besi; nilai batasan RET-He ≤ 28,9 pg (sensitivitas 78,9%, spesifisitas 56,2%, NDN 92,2%, dan NDP 28,9%) untuk defisiensi besi; dan nilai batasan RET-He ≤ 27 pg (sensitivitas 75%, spesifisitas 80%, NDN 98,1%, dan NDP 18,7%) untuk anemia defisiensi besi. Peneliti menarik kesimpulan bahwa RET-He dapat digunakan sebagai parameter skrining defisiensi besi dengan nilai batasan ≤ 28,9 pg. Skrining untuk anemia defisiensi besi dapat menggunakan RET-He dengan nilai batasan ≤ 27 pg, namun harus dilakukan dengan parameter lain, seperti Hb. Pemeriksaan RET-He dengan nilai batasan ≤ 30,3 pg tidak dapat digunakan untuk skrining deplesi besi.
Iron deficiency (ID) is the most common micronutrient deficiency in the world. Left untreated, ID will lead to iron deficiency anemia (IDA) and other irreversible consequences. Screening iron deficiency is complex, impractical, and expensive. The AAP recommended RET-He as an alternative laboratory examination to screen ID. The objective is to find RET-He cut-off value to screen for iron status in healthy children, aged 6 – 18 years old. This study is a cross-sectional study of 207 children aged 6 – 18 years old in Indonesia. RET-He was compared with hemoglobin, mean corpuscular volume, ferritin to assess iron status in children. Receiver operating curve was performed to determine the optimal cut-off value for RET-He using IBM SPSS 22. Reticulocyte hemoglobin equivalent with cut-off value ≤ 30.3 pg was established to screen iron depletion (100% sensitivity, 19.7% specificity, 100% NPV, 5.4% PPV); meanwhile RET-He ≤ 28.9 pg to screen iron deficiency (78.9% sensitivity, 56.2% specificity, 92.2% NPV, 28.9% PPV); and RET-He ≤ 27 pg to screen IDA (75% sensitivity, 80% specificity, 98.1% NPV, 18.7% PPV). The researcher concluded that RET-He can be used as an iron deficiency screening parameter with a cut-off value ≤ 28.9 pg. Screening for IDA with RET-He ≤ 27 pg need to be done with other parameters, such as Hb. RET-He ≤ 30.3 pg cannot be used for iron depletion."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
T59203
UI - Tesis Membership  Universitas Indonesia Library
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Rhyno Febriyanto
Status besi remaja usia 15-17 tahun dengan obesitas = Iron status on adolescence 15-17 years old with obesity
"Latar belakang: Remaja merupakan kelompok risiko tinggi defisiensi besi. Adanya obesitas pada remaja meningkatkan risiko defisiensi besi disebabkan perbedaan pola asupan dan inflamasi kronis derajat rendah.
Tujuan: Mengetahui status besi remaja usia 15 -17 tahun dengan obesitas.
Desain penelitian: Penelitian potong lintang pada remaja usia 15 ? 17 tahun di dua SMU Jakarta Pusat pada bulan September ? November 2015. Subjek dibagi 2 kelompok berdasar indeks massa tubuh (IMT). Subjek obes bila IMT≥P95 dan non-obes bila IMT ≥P5 -
Hasil penelitian: Diperoleh 100 subyek yang memenuhi kriteria inklusi dan eksklusi. Berdasarkan indeks massa tubuh (IMT) diperoleh 52 subjek obes dan 48 subjek non-obes. Tidak terdapat perbedaan bermakna secara statistik proporsi defisiensi besi dan anemia defisiensi besi pada kelompok obes dan non-obes (9,6% vs 16,7%; p=0,295). Tidak terdapat perbedaan bermakna asupan besi total kelompok obes dan non-obes ( 8 (2,6 ? 95,9) mg/hari vs 10 (1,8 ? 83,4) mg/hari; p=0,188). Persentase asupan besi heme kelompok obes lebih tinggi dibandingkan kelompok non-obes ( 31 (0,0 ? 95,6)% vs 20 (15,2 ? 100,0)%; p=0,029).
Simpulan: Tidak terdapat perbedaan bermakna secara statistik proporsi defisiensi besi dan anemia defisiensi besi remaja usia 15 ? 17 tahun dengan obes dan non-obes. Tidak terdapat perbedaan rerata asupan besi remaja usia 15 - 17 tahun dengan obes dan non obes.
Background. Adolescent period is high risk group of iron deficiency. Obesity can increase the risk of iron deficiency. It was caused by low iron intake and low grade chronic inflammation.
Objective. To assess whether obese adolescents, who often have poor dietary habits, are at increased risk of iron deficiency.
Methods: Cross-sectional study on adolescence 15 to 17 years old in Senior High School in Central Jakarta between September to November 2015. Subject was divided into 2 groups based on body mas index (BMI). Obese group if BMI ≥P95 and non-obese group if BMI ≥P5 -
Results. There are 100 subjects that meet the inclusion and exclusion criteria. There was no significance difference proportion of iron deficiency and iron deficiency anemia between obese and non-obese group (9,6% vs 16,7%; p=0,295). Both groups did not significantly differ in total iron intake ( 8 (2,6 ? 95,9) mg/day vs 10 (1,8 ? 83,4) mg/ day; p=0,188). Obese groups have higher heme iron intake than non-obese groups ( 31 (0,0 ? 95,6)% vs 20 (15,2 ? 100,0)%; p=0,029).
Conclusion. Proportions of iron deficiency and iron deficiency anemia were same in both adolescence group. There was no difference in iron intake in obese and non-obese adolescence."
Depok: Universitas Indonesia, 2016
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Anton Dharma Saputra
Kadar Immature Platelet Fraction pada Pasien Anak dengan Immune Thrombocytopenia dan Leukemia = Immature Platelet Fraction among Pediatric Immune Thrombocytopenia and Leukemia Patients
"Latar belakang: Immune thrombocytopenia (ITP) didiagnosis dengan mengekslusi penyebab lain trombositopenia. Mekanisme trombositopenia terjadi melalui 2 mekanisme, yaitu destruksi trombosit seperti pada pasien ITP dan penurunan produksi trombosit pada pasien leukemia. Aspirasi sumsum tulang merupakan metode yang dapat membedakan mekanisme trombositopenia yang terjadi, tetapi karena invasif tidak rutin dilakukan untuk diagnosis. Seiring dengan perkembangan zaman, dapat dilakukan pemeriksaan trombosit muda dengan teknik flouresensi untuk menilai kadar immature platelet fraction (IPF). Penelitian ini dilakukan untuk membandingkan kadar IPF pada pasien ITP dibandingkan dengan leukemia.
Metode: Studi potong-lintang kadar IPF pasien anak dengan ITP dan leukemia, yang dilaksanakan dari 2017-2020 di RSUPN Cipto Mangunkusumo, Jakarta. Sampel penelitian adalah pasien anak umur kurang dari 18 tahun, yang menderita ITP dan leukemia, yang belum mendapatkan kemoterapi ataupun imunosupresan. Data penelitian diambil dari rekam medis atau pemeriksaan darah rutin.
Hasil: Dari 42 pasien, didapatkan 21 pasien ITP dan 21 pasien leukemia. Terdapat perbedaan bermakna (16,6 poin) dari rerata kadar IPF pasien ITP dibandingkan pasien leukemia (P<0,001). Pasien ITP memiliki kadar rerata IPF sebesar 18,6%(SB 12,1%). Pasien leukemia memiliki kadar IPF 2%(SB 1,31%).
Kesimpulan: Terdapat perbedaan bermakna kadar IPF pada pasien ITP dibandingkan pasien leukemia akut.
.Background and aim: Immune thrombocytopenia (ITP) is diagnosed by excluding other causes of thrombocytopenia. The thrombocytopenia itself could occur through 2 mechanisms, which were platelet destruction as in ITP, and decrease platelet production as in leukemia. Bone marrow aspiration used to be done to distinguish the mechanism of thrombocytopenia, but it has not been routinely done due to its invasiveness. Examination of young platelets with fluorescence technique are currently done to assess the level of Immature Platelet Fraction (IPF). This study was conducted to evaluate the differences in IPF levels in ITP patients compared with leukemia patients.
Methods: A cross-sectional study was carried out on the IPF levels on patients with ITP and leukemia, from 2017-2020 at Cipto Mangunkusumo General Hospital, Jakarta. The study sample was pediatric patients, less than 18 years old, diagnosed with ITP and acute leukemia, whom had not received any chemotherapy or immunosuppressants. Research data were taken from medical records and/or routine blood tests.
Results: Total of 42 patients, 21 ITP patients and 21 leukemia patients were found. There was a significant difference (16,6 poin) in the mean of IPF levels of ITP patients compared with leukemia patients (P <0.001). ITP patients had an average IPF level of 18,6% (SB 12,1). Leukemia patients have 2% IPF levels (SB 1,31).
Conclusions: There is a subtantial different in IPF in ITP patient compared to acute leukemia patients. "
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Jane Estherina Fransiska
Korelasi Jumlah Trombosit dan Immature Platelet Fraction dengan Fungsi Agregasi Trombosit Pada Pasien Trombositopenia = Correlation between Platelet Count and Immature Platelet Fraction with Platelet Aggregation Function in Patient with Trombocytopenia
"Latar Belakang: Risiko perdarahan tidak berkorelasi linear dengan jumlah trombosit pada kondisi trombositopenia. Terdapat perbedaan fungsi trombosit pada trombositopenia gangguan produksi dengan destruksi perifer. Pada trombositopenia, hasil fungsi agregasi trombosit dengan light transmission aggregometry tidak valid. Diperlukan pemeriksaan fungsi trombosit yang dapat dikerjakan pada kondisi trombositopenia.
Tujuan: Mengkaji fungsi agregasi trombosit pada pasien trombositopenia
Metode: Studi potong lintang terhadap 60 pasien trombositopenia gangguan produksi dan destruksi perifer di Rumah Sakit Cipto Mangunkusumo selama Desember 2023 sampai April 2024. Dilakukan pemeriksaan jumlah trombosit, IPF, dan fungsi agregasi trombosit.
Hasil: Terdapat perbedaan fungsi agregasi antara trombositopenia gangguan produksi dengan destruksi perifer (40% vs 77,7%). Didapatkan perbedaan nilai IPF antara trombositopenia gangguan produksi dengan destruksi perifer (5,65% vs 21%). Tidak didapatkan korelasi antara jumlah trombosit dengan fungsi agregasi trombosit pada trombositopenia gangguan produksi maupun destruksi perifer (r=0,214, p=0,231; r=0,364 p=0,062). Tidak didapatkan korelasi antara jumlah trombosit dengan fungsi agregasi trombosit pada trombositopenia gangguan produksi maupun destruksi perifer. Didapatkan titik potong IPF 10,25% untuk membedakan trombositopenia gangguan produksi dan destruksi perifer dengan sensitivitas 80,8% dan spesifisitas 68%.
Kesimpulan: Fungsi agregasi trombosit pada trombositopenia destruksi perifer lebih baik daripada trombositopenia gangguan produksi. Fungsi agregasi trombosit tidak berkorelasi dengan jumlah trombosit maupun dengan IPF.
Background: The risk of bleeding does not linearly correlate with platelet count in thrombocytopenia.There is difference between platelet function in central and peripheral thrombocytopenia. Platelet aggregation function assay performed by light transmission aggregometry is not valid in thrombocytopenia. Platelet aggregation assay that can be performed in thrombocytopenia is needed.
Objective: To assess platelet function in thrombocytopenia patients.
Methods: A cross-sectional study was conducted on 60 thrombocytopenic patients at Cipto Mangunkusumo Hospital from December 2023 to April 2024. Platelet count and immature platelet fraction (IPF) were done by automatic blood cell counter while platelet aggregation by Plateletworks ADP Kit
Results: There was a difference in platelet aggregation function between central thrombocytopenia and peripheral thrombocytopenia (40% vs 77.7%). A difference in IPF values was found between central thrombocytopenia and peripheral thrombocytopenia (5.65% vs. 21%). No correlation between platelet count and platelet aggregation function in thrombocytopenia (r=0.214, p=0.231 vs. r=0.364, p=0.062). No correlation was found between IPF and platelet aggregation function (r=-0.139, p=0.498 vs. r=-0.282, p=0.171). The cut-off value of IPF was 10.25% to distinguish central and peripheral thrombocytopenia.
Conclusion: Platelet aggregation function in peripheral thrombocytopenia was better than central thrombocytopenia. Platelet aggregation function did not correlate neither platelet count nor IPF."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Kartika Sari Widuri
Profil zat besi bayi usia 9-12 bulan: hubungan dengan status gizi dan zat pemacu serta penghambat absorpsi besi dalam asupan diet = Iron profile of 9-12 month-old babies: correlation with nutritional status, enhancers and inhibitors of iron absorption in daily dietary intake / Kartika Sari Widuri
"ABSTRAK
Latar belakang: Anemia defisiensi besi ADB pada usia 9-12 bulan dapat berdampak pada kualitas hidup anak di masa depan. Asupan zat besi, pemacu dan penghambat absorpsi besi memengaruhi kadar besi tubuh. Penelitian mengenai status zat besi dan hubungannya dengan zat pemacu dan penghambat absoprsi dalam asupan diet pada bayi usia 9 ndash;12 bulan yang disertakan dengan analisis asupan diet belum banyak dilakukan di Indonesia. Tujuan: Mengetahui prevalens gangguan status besi dan mengetahui hubungan status gizi dan kecukupan asupan besi harian terhadap kejadian defisiensi besi pada bayi usia 9-12 bulan. Metode: Studi potong lintang pada Juli 2017-Januari 2018 di Posyandu kecamatan Tanah Abang dan Jatinegara. Asupan zat besi, pemacu absorpsi besi dan penghambat absorpsi besi dinilai dengan metode food record dan diolah dengan program NutriSurvey . Subyek menjalani pengukuran antropometri dan pengambilan sampel darah darah perifer lengkap, LED, dan feritin serum . Data diolah dengan uji Pearson Chi Square dan kejadian gangguan status besi ditampilkan dalam prevalens. Hasil: Terdapat 82 subyek usia 9-12 bulan berpartisipasi dalam penelitian. Prevalens defisiensi besi sebesar 12,2 , dan ADB sebesar 26,8 . Tidak terbukti ada hubungan antara kecukupan asupan besi harian dengan gangguan status besi [p=0,064; PR=2,1 0,193-1,178 ] dan status gizi kurang dengan gangguan status besi [p=0,444; PR=0,729 0,307-1,731 ]. Terdapat perbedaan bermakna antara asupan harian besi total p=0,002 , besi heme 0,017 , kalsium p=0,006 , dan seng p=0,042 antara kelompok defisiensi besi dan non-defisiensi besi.Simpulan: Prevalens defisiensi besi dan ADB pada bayi usia 9-12 bulan berturut-turut adalah 12,2 dan 26,8 . Tidak terbukti ada hubungan antara status gizi dan kecukupan asupan besi harian dengan gangguan status besi, namun terdapat perbedaan bermakna antara asupan harian besi total, besi heme, kalsium, dan seng antara kelompok defisiensi dan non-defisiensi besi pada populasi bayi usia 9-12 bulan.
ABSTRACT
Background Iron deficiency anemia IDA in 9 12 month old babies could affect their quality of life. Intake of iron containing food, enhancer and inhibitor of iron absorption affects iron body level. Study about iron profile and its correlation with enhancers and inhibitors of iron absorption in baby rsquo s daily dietary intake whose analyzed by food record method is still infrequent in Indonesia. Aim To measure the prevalence of iron deficiency and IDA and to know the correlation of nutritional status and adequacy of daily iron intake with iron deficiency status in 9 12 month old babies. Methods A cross sectional study was conducted on July 2017 January 2018 in Posyandu in Tanah Abang and Jatinegara district. Dietary iron intake, enhancer and inhibitor were obtained using a 3 day food record method and analyzed with NutriSurvey program. Subjects underwent anthropometry measurement. Complete blood count, ESR, and ferritin serum were also examined. Results A total of 82 babies aged 9 12 months were studied. Prevalence of iron deficiency and IDA were 12,2 and 26,8 . There were no evidence of relationship between adequacy of daily iron intake p 0,064 and undernourished condition p 0,444 with iron deficiency status. There were statistically significant differences in total iron p 0,002 , heme iron p 0,017 , calcium p 0,006 , and zinc p 0,042 daily intakes between iron deficiency group and non iron deficiency group.Conclusion The prevalence of iron deficiency and IDA were 12,2 and 26,8 . There were no evidence of relationship between adequacy of daily iron intake nor undernourished condition with iron deficiency status. There were statistically significant differences in total iron, heme iron, calcium, and zinc daily intakes between iron deficiency group and non iron deficiency group in 9 12 month old babies."
2018
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UI - Tesis Membership  Universitas Indonesia Library
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Dara Indira Diniarti
Status Besi pada Pasien Sindrom Nefrotik Idiopatik Aktif dan Remisi = Iron Status in Active and in Remission Idiopathic Nephrotic Syndrome
"Latar belakang: Sindrom nefrotik (SN) idiopatik merupakan penyakit glomerulus dengan proteinuria akibat peningkatan permeabilitas glomerulus. Transferin merupakan salah satu protein yang keluar di urin dan dapat mengganggu homeostasis besi. Keadaan ini dapat menyebabkan defisiensi besi dan anemia defisiensi besi (ADB).
Tujuan: Mengetahui perbedaan status besi, transferin urin, proporsi defisiensi besi dan ADB pada pasien SN idiopatik aktif dan remisi.
Metode: Penelitian potong lintang pada pasien SN idiopatik aktif dan remisi usia 1-18 tahun di RSCM. Pengukuran status besi menggunakan Hb,MCV, MCH, Ret-He, SI, TIBC, ferritin, dan saturasi transferin. Pengukuran transferin urin menggunakan metode enzyme-linked immunosorbent assay (ELISA).
Hasil: Terdapat 65 subyek, dengan 32 pasien SN idiopatik aktif dan 33 pasien remisi. Kadar SI antara kelompok aktif dan remisi adalah 60,7±33,5 µg/dL dan 84,6±35,3 µg/dL (p<0,05). Kadar TIBC antara kelompok aktif dan remisi adalah 220±90,7 µg/dL dan 309,4(±47,7) µg/dL (p<0,05). Kadar transferin urin antara kelompok aktif dan remisi adalah 435,3(7,7-478,4) ng/mL dan 23,4 (0-358) ng/mL (p<0,05). Proporsi defisiensi besi dan ADB pada kelompok aktif adalah 7(21,9%) dan 5 (15,6%) subyek, sedangkan pada kelompok remisi adalah 4(12,6%) dan 1(3%) subyek. Perbedaan proporsi tersebut tidak bermakna (p=0,04; RR 2,47; IK95% 0,98-6,23).
Kesimpulan: Kelompok SN idiopatik aktif memiliki nilai SI dan TIBC yang rendah serta transferin urin yang tinggi. Proporsi defisiensi besi dan ADB pada kelompok SN idiopatik aktif lebih tinggi walaupun tidak bermakna secara statistik.
Background: Idiopathic nephrotic syndrome (NS) is a common glomerular disease in children, which cause increased glomerular permeability resulting in proteinuria. Transferrin is one of the protein that is excreted in the urin, thus disturbing iron homeostasis and may lead to iron deficiency (ID) or iron deficiency anemia (IDA).
Objective: To know the differences in iron status, urinary transferrin, and the proportion of ID and IDA in children with active and remission idiopathic NS.
Methods: A cross-sectional design study was conducted on patients with active and remission idiopathic NS aged 1-18 years at RSCM. Measurement of iron status using Hb, MCV, MCH, Ret-He, SI, TIBC, ferritin, and transferrin saturation. Measurement of urinary transferrin using enzyme-linked immunosorbent assay (ELISA).
Result: There were 65 study subjects, with 32 patients with active idiopathic NS and 33 subjects were in remission.The SI levels between the active and remission groups were 60.7±33.5 g/dL and 84.6±35.3 g/dL (p<0.05). The TIBC levels between the active and remission groups were 220±90.7 g/dL and 309.4(±47.7) g/dL (p<0.05). The median of urinary transferrin levels between the active and remission groups were 435.3(7.7-478.4) ng/mL and 23.4 (0-358) ng/mL (p<0.05). The proportions of ID and IDA in the active group were 7(21.9%) and 5(15.6%) subjects, while in the remission group were 4(12.6%) and 1(3%) subjects. Nonetheless the difference were not statistically significant (p=0.04; RR 2.47; CI95% 0.98-6.23).
Conclusion. Active idiopathic NS had significant lower values of SI and TIBC, and higher urinary transferrin levels. The proportion of ID and IDA in the active group was higher, although not significant."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
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UI - Tugas Akhir  Universitas Indonesia Library
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Fatimah Eliana
Faktor Risiko Anemia dan Status Cadangan Besi pada Usia Lanjut = Risk Factors for Anemia and Iron Reserve Status in the Elderly
"Seiring dengan kemajuan tingkat perawatan kesehatan dan penurunan jumlah kelahiran, maka jumlah penduduk usia lanjutpun akan semakin meningkat. Keadaan ini tidak hanya terjadi di negara-negara industri tapi juga pada negara-negara berkembang. Di wilayah Asia Tenggara proporsi penduduk berumur Iebih dari 60 tahun akan meningkat dari 5 % pada tahun 1950 menjadi 11,25 % pada tahun 2050. Di Indonesia berdasarkan data proyeksi penduduk tahun 1990-2025 dari Badan Pusat Statistik didapatkan peningkatan usia harapan hidup. Pada tahun 1992 usia harapan hidup penduduk Indonesia 62,34 tahun dan pada tahun 1997 menjadi 64,25 tahun, sedangkan pada tahun 2002 diperkirakan dapat mencapai usia 68,23 tahun. Hal ini menunjukkan bahwa jumlah penduduk usia lanjut akan semakin meningkat dari tahun ke tahun. Pada tahun 2005-2010 jumlah usia lanjut diperkirakan sekitar 19 juta jiwa atau 8,5 % dari seluruh jumlah penduduk.
Along with the progress of health care levels and the decrease in the number of births, the number of elderly people will also increase. This situation not only occurs in industrialized countries but also in developing countries. In the Southeast Asian region, the proportion of the population aged 60 years and older will increase from 5% in 1950 to 11.25% in 2050. In Indonesia, based on population projection data for 1990-2025 from the Central Statistics Agency, an increase in life expectancy was obtained. In 1992 the life expectancy of the Indonesian population was 62.34 years and in 1997 it was 64.25 years, while in 2002 it was estimated to reach 68.23 years, thing this shows that the number of elderly population will increase from year to year. In 2005-2010 the number of elderly people was estimated at around 19 million people or 8.5% of the total population."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
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UI - Tesis Open  Universitas Indonesia Library
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