Hasil Pencarian  ::  Simpan CSV :: Kembali

"Irritable bowel syndrome (IBS) is the most common functional disorder of the gastrointestinal tract. As a result of the lack of specific diagnostic testing and absence of circumscribed biology markers of the disease, its diagnosis is based on a myriad of symptoms. The term irritable bowel syndrome was probably first coined in 1944 by Peters and Bargenf. ln 1849, Cumming described the clinical manifestations of Irritable Bowel Syndrome. Irritable bowel syndrome is defined an the basis of the recently modified Rome criteria as the presence of at least l2 weeks (not necessarily consecutive) of abdominal discomfort or pain in the preceding l2 months that cannot be explained by structural or biochemical abnormalities, and that has at least two of the following three features: pain relieved with defecation, an onset associated with a change in the frequency of bowel movements (diarrhea or constipation), or an onset associated with a change inform of stool (loose, watery, or pellet-like). The syndrome can be divided into three subcategories according to the Modmed Rome criteria ll; those with a predominant symptom of diarrhea, constipation, or constipation alternating with diarrhea. There are Several criteria for irritable bowel syndrome, one of which is the Manning criteria applied in many epidemiological and clinical studies to identify irritable bowel syndrome. However, many investigators disagree with this criteria due to a seemingly poor validity in men. In an attempt to bring order to the specialty, consensus-based approach is adopted by a group of international experts, which led to the development ofthe Rome criteria for irritable bowel syndrome (Table l). Extra-intestinal symptoms, including headache, backache, urinary and gynecologic symptoms, and fatigue, are more common in the constipation-predominant subgroup"

"ABSTRAKLatar Belakang. Irritable bowel syndrome (IBS) merupakan nyeri perut berulang pada remaja yang paling banyak terjadi. Irritable bowel syndrome pada remajaakan menimbulkan gangguan yang serius berupa masalah perilakunya.Tujuan. Menganalisis hubungan antara masalah perilaku dengan Irritable bowel syndrome pada remaja di Kota Palembang.Metode. Penelitian ini adalah studi potong lintang. Semua siswa SMA Nurul Iman dilakukan pencatatan meliputi karakteristik umum, pemeriksaan fisik berupa berat badan dan Tinggi badan. Selanjutnya dilakukan uji Rome III (Irritable bowel syndrome) dan PSC-17 (masalah perilaku). Analisis statistik yang digunakan adalah analisis bivariat dengan uji chi-square.Hasil. Dari semua siswa SMA Nurul Iman didapatkan 180 subyek yang memenuhi kriteria inklusi dan tidak memenuhi kriteria eksklusi. Prevalens IBS sebanyak 58 subyek (32,2%) yang terdiri dari 22 subyek dengan IBS subtipekonstipasi, 23 subyek dengan IBS subtipe diare dan 13 subyek dengan IBS subtype campuran. Prevalens masalah perilaku sebesar 40,6% yang terdiri dari 28,9% masalah perilaku internalisasi, 2,8% masalah eksternalisasi, 0,6% masalah perilaku perhatian dan 8,4% variasi dari 3 gangguan. Faktor risiko terjadinya IBS antara lain: mengonsumsi daging olahan, teh, makan terburu-buru, serta dibully. Terdapat hubungan yang bermakna antara IBS dengan masalah perilaku (p=0,001). Nilai Odds Ratio yang diberikan sebesar 3,015 (IK95%=1,580-5,754)Simpulan. Remaja yang mengalami IBS akan mengalami masalah perilaku.

---

ABSTRACT

Background. Irritable Bowel Syndrome (IBS) is the most common recurrent abdominal pain in adolescence, causing serious impairments on behavioral problems. To date, there have no studies on IBS and behavioral problems in

Palembang.

Objective. To assess for an association between IBS and behavioral problems in adolescences in Palembang.

Methods. Subjects in this cross-sectional study were adolescences who attended Nurul Iman high school. Their general characteristics, developmental history and

physical examination results (including weight and height) were recorded. We administered the Criteria Rome III for IBS and the Pediatric Symptom Checklist 17 (PSC 17) for behavioral problems. Data was analyzed by Chi-square test.

Results. We enrolled 180 adolescences as student in Nurul Iman high school. Prevalences of IBS was 32,2%, consisting of subtype IBS constipation (37,9%),

subtype IBS Diarrhea (39,7%), and subtype IBS Mixed (22,4%). The prevalence of behavioral disorders was 40,6%, consisting of internalization (28,9%),

externalization (2,8%), attentive problems (0,6%) and various combinations of three problems (8,4%). A significant association was found between IBS and

behavioral problems (P=0.001; OR=3.015 95%CI=1.580-5.754).

Conclusion. IBS is significantly associated with behavioral problems."

"

Irritable Bowel Syndrome (IBS) merupakan penyakit terbanyak pada anak dan remaja pada gangguan saluran cerna fungsional dengan subtipe diare, konstipasi, campuran dan unclassified. Mekanisme patofisiologi belum jelas dan memerlukan pembuktian adanya keterlibatan organik. Tujuan penelitian ini adalah untuk mengetahui epidemiologi IBS, peran infestasi Blastocystis hominis dan integritas mukosa usus dalam etiopatogenesis IBS, dampak IBS terhadap kualitas hidup, serta membuat sistem model prediksi IBS pada remaja.

Penelitian ini berbasis komunitas dengan pendekatan potong lintang komparatif dua kelompok pada remaja dari enam SMA di Palembang. Kriteria Roma III digunakan untuk menegakkan diagnosis IBS beserta kuesioner untuk menentukan faktor risiko. Secara multistage random sampling dibandingkan 70 subjek IBS dan 70 subjek nonIBS. Dilakukan pencatatan riwayat medis, pemeriksaan fisis, pemeriksaan parasit dan biomarker tinja serta kuesioner IBSQOL. Pemeriksaan tinja segar dengan mikroskop untuk mengetahui infestasi Blastocystis hominis. Pemeriksaan kadar alfa-1 antitripsin dan kalprotektin tinja dengan ELISA untuk melihat adanya gangguan integritas mukosa usus. Dampak IBS terhadap kualitas hidup dinilai dengan kuesioner IBSQOL.

Terdapat  454 subjek dengan prevalens IBS 30,2%, terdiri dari subtipe terbanyak yaitu subtipe diare 36,5%, dan yang paling sedikit subtipe konstipasi 18,9%. Uji regresi logistik mendapatkan faktor risiko utama IBS adalah dibully, perempuan, usia 14–16 tahun, riwayat konstipasi, makan tiga jenis kacang, minuman kemasan, dan riwayat diare (kisaran OR 2,86–1,81). Blastocystis hominis ditemukan pada masing-masing grup sebesar 51,4 vs. 28,6%, dengan perbedaan bermakna (p = 0,006). Tidak ada hubungan bermakna untuk kerusakan mukosa (p = 0,734), tetapi bermakna dengan inflamasi usus (p = 0,039). Terbukti IBS secara bermakna menyebabkan rendahnya kualitas hidup (p = 0,001). Didapatkan 2 model prediksi skoring, yaitu model 1 yang dapat diaplikasikan pada layanan kesehatan primer yang bertujuan sebagai uji tapis dengan menilai faktor risiko. Model 2 diperuntukkan sebagai layanan terapi terkait infestasi Blastocystis pada layanan kesehatan tersier.

Simpulan, prevalens IBS pada remaja di Palembang tinggi dan memiliki faktor risiko utama dibully, perempuan, usia 14–16 tahun, riwayat konstipasi, makan 3 jenis kacang, minuman kemasan, riwayat diare. Terdapat hubungan yang bermakna antara Blastocystis hominis dan inflamasi usus dengan kejadian IBS pada remaja, serta dampaknya terhadap kualitas hidup membutuhkan penanganan yang komprehensif.

Kata kunci: Blastocystis hominis, integritas mukosa usus, irritable bowel syndrome, kualitas hidup, remaja

---

Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder and commonly present in children and adolescences, presented as diarrhoea, constipation, mixed or unclassified type. The pathophysiological mechanisms of  IBS are unclear, and still challenging to determine organic disorders. The aim of this study was to investigate the epidemiology of IBS, the role of Blastocystis hominis infestation and intestinal mucosal integrity in the etiopathogenesis of IBS, the impact of quality of lifes, and apply a scoring system to predict the occurrence of IBS among adolescences.

A community-based survey with comparative cross sectional approach was done from six high schools in Palembang. Subjects were recruited using the multistage random sampling divided into two groups (70 subjects IBS and 70 subjects nonIBS). The Rome III criteria were used to establish a diagnosis of IBS along with a questionnaire to determine risk factors,  analyzed for association with Blastocystis hominis infestation, intestinal mucosal integrity, and its impact on quality of life. Direct microscopic stool examination to identify single Blastocystis infection was performed, followed by culture in Jones’ medium, PCR and Sequencing of 18S rRNA to determine Blastocystis subtype. Examination of antitrypsin alpha-1 and fecal calprotectin levels by ELISA was done  to determine impaired intestinal mucosal integrity. Impact of IBS on quality of life was done with the IBSQOL questionnaire.

Of the 454 subjects, the prevalence of IBS was 30.2%, consisting of diarrhea subtypes 36.5%, 21.9% mixed, 22.6% Unclassified and 18.9% constipation. The major risk factors for IBS were bullying, girls, ages 14–16 years, history of constipation, eat three kinds of nuts, drink beverages, and history of diarrhea (range OR 2.86–1.81). Blastocystis hominis was detected in each group of 51.4 vs. 28.6% (p = 0.006). There was no significant association for intestinal mucosal permeability (p = 0.734), but it was significant with intestinal inflammation (p = 0.039). Significant impairment of quality of life among IBS adolescences was found (p = 0.001). The IBS prediction score model had 2 models. Model 1 is more applicable in primary health care for sreening IBS based on risk factors. Model 2 only usable for tertiary health care, as management of Blastocystis infestation.

Conclusion, the prevalence IBS among adolescence was high with major risk factors to IBS consisted of bullying, female gender, age between 14–16 years, previous illness of constipation, diet three nuts, drink beverages, previous illness diarrhoea. Significant association with Blastocystis hominis infestation, intestinal inflammation were found, comphrehensive management is needed as for its impact on quality of life.

Keywords. Blastocystis hominis, intestinal integrity, irritable bowel syndrome,   quality of life, Adolescences

 

"

"Terdapat empat faktor yang dapat mempengaruhi tingkat stres mahasiswa keperawatan, yaitu faktor pendidikan, persiapan klinis, kepercayaan dan keuangan. Keempat faktor stres tersebut dapat berdampak ke salah satu penyakit secara fisiologis yaitu gejala sindrom iritasi usus besar. Sehingga penelitian ini dianalisis menggunakan uji Gamma untuk mengidentifikasi hubungan antara tingkat stres pendidikan, persiapan klinis, kepercayaan dan keuangan dengan gejala sindrom iritasi usus besar pada mahasiswa keperawatan. Pengumpulan data menggunakan kuesioner Stress in Nursing Students Scale (SINS) dan Gastrointestinal Symptom Rating Scale for Irritable Bowel Syndrome (GSRS-IBS). Desain penelitian yang digunakan adalah cross sectional dengan teknik sampel proportionate stratified random sampling melalui rumus perhitungan besaran sampel slovin, sehingga melibatkan 212 mahasiswa tanpa sistem drop out. Hasil penelitian ini menunjukan bahwa tingkat stres pendidikan, persiapan klinis, kepercayaan dan keuangan berhubungan signifikan, arah korelasi positif dengan kekuatan korelasi yang lemah terhadap gejala sindrom iritasi usus besar pada mahasiswa keperawatan. Oleh karena itu, dapat di simpulkan bahwa Semakin tinggi tingkat stres pendidikan, persiapan klinis, kepercayaan dan keuangan maka akan mengalami tingkat gejala sindrom iritasi usus besar semakin tinggi juga.

---

There are four factors which can influence the stress level of nursing students, namely education, clinical preparation, confidence and finance. The four stress factors can have an impact on one of physiologically diseases is the irritable bowel syndrome symptoms. So this study analyzed using Gamma test to identify the relation between stress levels of education, clinical preparation, confidence and finance with symptoms of irritable bowel syndrome in nursing students. Data collection using the Stress in Nursing Students Scale (SINS) and Gastrointestinal Symptom Rating Scale for Irritable Bowel Syndrome (GSRS-IBS) questionnaire.

The research design used is cross sectional with a proportionate stratified random sampling technique by means of the slovin sample unit calculation formulae, so that it involves 212 nursing students without drop out system.

The results of this study indicate that the stress level of education, clinical preparation, confidence and finance is significantly related, positively correlated with a weak correlation strength to irritable bowel syndrome symptoms in nursing students. Therefore, it can be concluded that the higher the level of stress in education, clinical preparation, confidence and finance, the higher the level of irritable bowel syndrome symptoms, too."

"Latar Belakang: Obstruksi usus strangulata merupakan masalah kegawatdaruratan yang sering ditemui, mencakup 20% dari total pasien di unit gawat darurat. Obstruksi usus strangulata memiliki morbiditas dan mortalitas yang tinggi. Terdapat banyak faktor yang memengaruhi luaran pascaoperasi obstruksi usus strangulata, dan sebgaian besar berhubungan dengan komplikasi respirasi, infeksi daerah operasi, dan acute kidney injury (AKI). Tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor yang memengaruhi morbiditas dan mortalitas pascaoperasi pada pasien dengan obstruksi usus strangulata.Metode: Studi kohort retrospektif dengan menggunakan total sampling dari registrasi Divisi Bedah Digestif dari tahun 2015-2019. Analasis bivariat digunakan dengan menggunakan studi Chi Square, Fisher, Mann Whitney, dan Spearman. Total 133 pasien tercakup di dalam analisis studi.Hasil: Angka mortalitas obstruksi usus strangulata di RS Cipto Mangunkusumo sebesar 7,5%. Angka kejadian acute kidney injury (AKI) pascaoperasi sebesar 30,1%. Terdapat beberapa faktor yang berhubungan dengan luaran morbiditas dan mortalitas, seperti usia pasien, onset strangulata, kondisi sepsis, dan kadar asam laktat serum.Kesimpulan: Faktor-faktor seperti usia pasien, onset strangulata, kondisi sepsis, dan kadar asam laktat serum berpengaruh terhadap morbiditas dan mortalitas pascaoperasi pada pasien dengan obstruksi usus strangulata. Beberapa faktor lain juga berhubungan dengan luaran mortalitas

---

Background: Strangulated bowel obstruction is common emergency problem, included 20% of total patients registered to emergency department. Strangulated bowel obstruction is serious medical conditioin with high morbidity and mortality. There are many factors influencing postoperative outcome of strangulated bowel obstruction, and most related to respiratory complications, surgical site infection, and acute kidney injury. The objective of this study is to find out which factors contributing to postoperative morbidity and mortality in patients with strangulated bowel obstruction.Method: A cohort retrospective with total sampling is used from Digestive Surgery Division registry by the year 2015-2019. Bivariate analysis has been done using Chi Square, Fisher, Mann Whitney, and Spearman study. Total of 133 patients were included in the analysisResult: Mortality rate of strangulated bowel obstruction was 7,5% in Cipto Mangunkusumo Hospital. The acute kidney injury morbidity rate was 30,1%. There are some factors related to the postoperative morbidity and mortality outcome, such as age, strangulation onset, sepsis condition, and lactate acid serum level.Conclusion: Factors such as age, strangulation onset, sepsis condition, and lactate acid serum level are contributing to postoperative morbidity and mortality outcome in patients with strangulated bowel obstruction. Some of these factors also related to mortality outcome."

"Latar Belakang. Vitamin D merupakan salah satu komponen regulator yang berperan dalam respons imun humoral maupun adaptif yang memiliki peranan patogenesis dalam berbagai kondisi autoimun termasuk IBD. Defisiensi vitamin D diketahui dapat mempengaruhi derajat aktivitas pada pasien dengan IBD. Beberapa studi menunjukkan terdapat peran vitamin D dalam meningkatkan angka remisi pada pasien dengan IBD. Namun studi lain menunjukkan tidak ada hubungan yang signifikan terhadap aktivitas klinis IBD dengan defisiensi vitamin D. Belum ada studi di Indonesia yang menilai hubungan kadar vitamin D dengan aktivitas klinis pada IBD.Tujuan. Mengetahui prevalensi defisiensi vitamin D pada pasien dengan IBD dan menilai perbedaan rerata kadar 25-OH D pada subjek dengan IBD aktif dengan remisi.Metode. Penelitian ini merupakan studi dengan desain potong lintang yang dilakukan di Rumah Sakit Cipto Mangunkusumo. Pasien dengan IBD yang datang ke Poliklinik Gastroenterologi dan dilakukan pemeriksaan kadar 25-OH-D. Subjek dengan kolitis ulseratif dinilai aktivitas klinisnya dengan menggunakan instrumen Simple Clinical Colitis Activity Index (SCCAI) dimana nilai <2 dikategorikan sebagai remisi, sedangkan subjek dengan penyakit Crohn dinilai aktivitas klinisnya dengan menggunakan instrumen Crohn’s Disease Activity Index (CDAI) dengan nilai <150 dikategorikan sebagai remisi. Dilakukan analisis perbedaan rerata kadar 25-OH-D antara subjek remisi dibandingkan aktif baik pada subjek dengan kolitis ulseratif dan penyakit Crohn.Hasil. Sebanyak 76 subjek memenuhi kriteria inklusi dan eksklusi, 48 subjek termasuk ke dalam kolitis ulseratif dan 28 lainnya penyakit Crohn. Sebanyak 65,3% subjek perempuan dengan rerata usia subjek adalah 46,39 (SB 16,25). Prevalensi defisiensi vitamin D pada pasien IBD adalah sebesar 46,1% dengan 32,1% pada penyakit Crohn dan 54,2% pada kolitis ulseratif. Tidak didapatkan adanya perbedaan median yang signifikan antara subjek dengan penyakit Crohn pada remisi (20,7 (12,25 – 32,55) ng/ml) dan aktif (15,7 (12,03 – 28,6) ng/ml) (p = 0,832), maupun subjek dengan kolitis ulseratif pada remisi (26,05 (19,33 – 30,73) ng/ml) dan aktif (25,05 (14,43 – 33,37) ng/ml) (p = 0,301).Kesimpulan. Prevalensi defisiensi vitamin D pada IBD adalah sebesar 46,1%. Tidak terdapat adanya perbedaan yang signifikan terhadap kadar 25-OH-D pada pasien dengan IBD yang aktif dibandingkan dengan remisi.

---

Background. Vitamin D is one of the regulatory components that play a role in humoral and adaptive immune responses that have a pathogenesis role in various autoimmune conditions including IBD. Vitamin D deficiency is known to affect activity levels in patients with IBD. Several studies have shown that there is a role for vitamin D in increasing remission rates in patients with IBD. However, other studies have shown that there is no significant relationship between clinical activity of IBD and vitamin D deficiency. There are no studies in Indonesia that have assessed the relationship between vitamin D levels and clinical activity in IBD.

Aim. To determine the prevalence of vitamin D deficiency in patients with IBD and to assess the difference in mean 25-OH D levels in subjects with clinically active and remission.

Method. This is a cross-sectional study conducted at Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Patients with IBD who came to the Gastroenterology Polyclinic and have their 25-OH-D levels checked. Subjects with ulcerative colitis were assessed for clinical activity using the Simple Clinical Colitis Activity Index (SCCAI) instrument where a value <2 was categorized as remission, while subjects with Crohn's disease were assessed for clinical activity using the Crohn's Disease Activity Index (CDAI) instrument with a value <150 categorized as remission. An analysis of the difference in mean 25-OH-D levels between remission versus active subjects was performed both in subjects with ulcerative colitis and Crohn's disease.

Results. A total of 76 subjects met the inclusion and exclusion criteria, 48 subjects had ulcerative colitis and 28 had Crohn's disease. A total of 65,3% of female subjects with the mean age of the subject was 46,39 (SB 16,25). The prevalence of vitamin D deficiency in IBD patients was 46,1% with 32,1% in Crohn's disease and 54,2% in ulcerative colitis. There was no significant median difference between subjects with Crohn's disease in remission (20,7 (12,25 – 32,55) ng/ml) and active (15,7 (12,03 – 28,6) ng/ml) (p = 0,832), as well as subjects with ulcerative colitis in remission (26,05 (19,33 – 30,73) ng/ml) and active (25,05 (14,43 – 33,37) ng/ml) (p = 0,301).

Conclusion. Prevalence of vitamin D deficiency in IBD is 46,1%. There was no significant difference in 25-OH-D levels in patients with active IBD compared with remission."

"ABSTRAKPenelitian ini adalah suatu studi untuk menentukan apakah M2 Piruvat Kinasedapat dipakai dalam menapis radang usus. Metode penelitian yang digunakanadalah uji diagnostik. Pada penelitian ini direkrut sampel sebanyak 76 orang dandilakukan pemeriksaan kolonoskopi sebagai baku emas dan pemeriksan M2-PKfeses sebagai pemeriksaan yang diuji.Dari hasil penelitian ini didapatkan peran penting M2 Piruvat Kinase untukmenapis radang usus dengan nilai titik potong 1,05 U/ml dibandingkan dengankolonoskopi sebagai baku emas dengan sensitivitas 86,2 %, spesifisitas 81,8%,nilai duga positif 96,6% dan nilai duga negatif 50%. Pemeriksaan M2 PiruvatKinase disarankan dari hasil studi ini untuk menapis radang usus pada pasiendengan masalah saluran cerna bagian bawah.

---

ABSTRACTThis is a study to evaluate possibility of M2-PK can be applied as a tool to screenof organic bowel inflammatory. Diagnostic test was used as a methode. In thisstudy 76 patient was recruited, colonoscopy was done as a gold standard and M2-PK faeces test was performed as a diagnostic test.As the result of this study, there is an important role of M2-PK test to screenorganic bowel inflammatory with cut off point >= 1.05 U/mL compared tocolonoscopy as a gold standard with sensitivity 86.2%, specificity 81,8%, positivepredictive value 96,6% and negative predictive value 50%. By this test result, it isstrongly recommended to performed M2-PK faeces test to screen organic bowelinflammatory."

"Latar Belakang/Tujuan: Pasien IBD berisiko terjadi defisiensi Zink. Sedangkan Zink memiliki peran dalam menstimulasi sistem imun, regenerasi sel, dan berperan sebagai koenzim yang berperan sebagai antioksidan. Pemberian suplementasi Zink diharapkan dapat menurunkan aktivitas penyakit dan meningkatkan aktivitsas antioksidan.Metode: Penelitian ini merupakan kajian sistematis dan meta-analisis. Pencarian literatur dilakukan sampai desember 2020 dengan mencari pada tiga database yaitu Cochrane central, Pubmed, dan Embase. Berdasarkan kriterian eligibilats didapatkan 9 artikel yang menilai efek Zink terhadap aktivitas penyakit IBD. Aktivitas penyakit dinilai berdasarkan skor CDAI dan skor Mayo, serta aktivitas enzim SOD.Hasil: Sebanyak 9 studi didapat dari pencarian, dilakukan analisis kualitatif dan kuantitatif. Meta-analisis dilakukan dengan membagi menjadi 3 subgrup, yaitu Zink terhadap aktivitas penyakit IBD, Zink terhadap aktivitas enzim SOD, serta aktivitas penyakit sebelum dan sesudah pemberian. Empat studi menilai efek Zink terhadap aktivitas penyakit menunjukkan tidak terdapat penutunan aktivitas penyakit IBD, dua studi menilai efek Zink terhadap aktivitas SOD menunjukkan tidak terdapat peningkatan aktivitas SOD, dua studi menilai efek Zink terhadap ekspresi metalotinonin datu studi menunjukkan peningkatan dan satu studi tidak menunjukkan peningkatan. Tiga studi pre dan post dari dua studi menunjukkan tidak terdapat penurunan aktivitas penyakit dan 1 studi menunjukkan penurunan aktivitas jika diberikan jangka panjang.Simpulan: Tidak didapatkan perbedaan aktivitas penyakit, aktivitas SOD, aktivitas metalotionin dengan suplementasi Zink jangka pendek, suplementasi jangka panjang dapat menurunkan aktivitas penyakit IBD

---

Background/Aim: IBD patients are at risk of Zinc deficiency. Zinc has a role in stimulating the immune system, cell regeneration, and as a coenzyme acts as an antioxidant. Zinc supplementation will decrease disease activity and increase antioxidant activity.

Method: This research is a systematic review and meta-analysis. Literature searches are conducted until December 2020, we searched in three databases Cochrane central, Pubmed, and Embase. Based on eligibility criteria, there are 9 articles evaluate effect of Zinc on disease activity of IBD. Disease activity is assessed based on CDAI score and Mayo score, as well as SOD enzyme activity.

Result: We identified 9 studies, Of all the potentially relevant papers, 9 studies were identified. All of the studies were assessed for risk of bias along with qualitative analysis. Pre-specified outcomes were Zinc and disease activity, Zinc and SOD activity, metallothionine expression as well as disease activity before and after administration. Four studies evaluated effect of Zinc on disease activity showed no improvement in IBD disease activity, two studies evaluated effect of Zinc on SOD activity showed no increase in SOD activity, two studies evaluated effect of Zinc on metalotinonin expression, one study showed increase of expression and the other had no increase. There are 3 pre and post studies from two studies showed no decrease in disease activity and 1 study showed a decrease in activity if supplemented for long term.

Conclusion: The results of the systematic review revealed there were no difference in disease activity, SOD and methalotionen activity with short term Zinc supplementation, long term supplementation decrease disease activity of IBD"