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"[ABSTRAKLatar belakang. Rekomendasi Global Alliance dalam penanganan AVS meliput antibiotik, asam retinoat, dengan atau tanpa BPO. Resistensi obat menjadi perhatian utama pada penggunaan antibiotik jangka panjang dalam terapi akne vulgaris sedang. Kombinasi antibiotik dan BPO direkomendasikan untuk mengatasi masalah tersebut. Pada tipe kulit IV-V hiperpigmentasi pasca akne merupakan masalah yang sering dikeluhkan. Tujuan. Membandingkan efektivitas, efek samping dan kejadian hiperpigmentasi pasca inflamasi penggunaan BPO sebagai paduan terapi lini pertama AVS pada tipe kulit IV-V Fitzpatrick. Metode. Penelitian analitik dengan desaain uji klinis acak tersamar ganda membandingkan dua sisi wajah. Subyek diberikan paduan terapi lini pertama. Sisi wajah perlakuan diberikan gel BPO 2,5% sedangkan kelompok kontrol gel plasebo. Hasil. Pada minggu ke-2,4,6,8 didapatkan penurunan persentase total lesi sebesar 51,47%, 71%, 75%, 82,84% pada kelompok BPO dan 30%, 53,75%, 62,28, 71% pada kelompok plasebo (p<0,001 .) Efek samping dan kejadian HPI pada minggu ke 2,4,6 dan 8 tidak berbeda bermakna. Kesimpulan. Penggunaan BPO sebagai bagian dari paduan terapi lini pertama AVS lebih efektif, tidak meningkatkan efek samping ataupun kejadian HPI.Kata kunci. akne vulgaris, gel BPO 2,5%,

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ABSTRACTBackground. Global alliance recommendation for moderate acne treatment are antibiotic, retinoic acid with or without benzoyl peroxide. Drug resistance become the most common problem due to longterm use of antibiotic in acne treatment. Combination of antibiotic and BPO is recommeded to overcome this problem. In patient with skin type IV-V post acne hyperpigmentation is one of the most significant complaint. Aim. To compare efectivity, side effect and post inflammatory hyperpigmentation of BPO 2,5% gel as a part of first line therapy regiment in patient with skin type IV-V. Method. This is an analytic study with randomized control trial design comparing both half-face (split-face). Subjects were given first line therapy regiment. Half-face was given BPO 2,5% gel twice daily while other half face with placebo. Result. Total lesions reduction in BPO group on week 2,4,6,8 were 51,47%, 71%, 75%, 82,84% respectively and 30%, 53,75%, 62,28, 71% in placebo group respectively. Conclusion. BPO as a part of first line therapy regiment for moderate acne is more effective, with no increase of side effect nor post inflammatory hyperpigmentation compared to placebo., Background. Global alliance recommendation for moderate acne treatment are antibiotic, retinoic acid with or without benzoyl peroxide. Drug resistance become the most common problem due to longterm use of antibiotic in acne treatment. Combination of antibiotic and BPO is recommeded to overcome this problem. In patient with skin type IV-V post acne hyperpigmentation is one of the most significant complaint. Aim. To compare efectivity, side effect and post inflammatory hyperpigmentation of BPO 2,5% gel as a part of first line therapy regiment in patient with skin type IV-V. Method. This is an analytic study with randomized control trial design comparing both half-face (split-face). Subjects were given first line therapy regiment. Half-face was given BPO 2,5% gel twice daily while other half face with placebo. Result. Total lesions reduction in BPO group on week 2,4,6,8 were 51,47%, 71%, 75%, 82,84% respectively and 30%, 53,75%, 62,28, 71% in placebo group respectively. Conclusion. BPO as a part of first line therapy regiment for moderate acne is more effective, with no increase of side effect nor post inflammatory hyperpigmentation compared to placebo.]"

"Cedar kulit terkait perekat medis sering terjadi baik diperawatan biasa, intensif maupun rawat jalan. Cedera kulit merupakan stressor fisik yang dapat menimbulkan nyeri, rasa tidak nyaman dan dapat menjadi tempat masuknya kuman atau bakteri. Cedera kulit pada anak diruang intensif disebabkan oleh penggunaan perekat medis seperti pemasangan NGT, ETT, IV Line, elektroda maupun Spo2. Cedera kulit masih sering dianggap hal yang biasa bahkan pendokumentasiannya masih jarang dilakukan baik di RS pemerintah maupun swasta. Cedera kulit dapat menyebabkan trauma, menimbulkan infeksi dan tentunya hal ini menyebabkan hari rawat semakin panjang. Dalam keperawatan modern diperlukan ketrampilan yang baik dalam mencegah cedera kulit terkait perekat medis. Identifikasi pasien beresiko tinggi cedera kulit, menentukan langkah yang tepat serta tehnik pemakain dan pelepasan perekat sangat diperlukan dalam rangka pelayanan keperawatan yang semakin optimal.

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Skin injuries are physical stressors that can cause pain, discomfort and can harbor germs or bacteria. Skin injuries to children in intensive rooms are caused by the use of medical adhesives such as the insertion of NGT, ETT, IV Line, electrodes or Spo2. Injuries to the skin are still considered commonplace and even documentation is rarely done in both government and private hospitals. Injuries to the skin can cause trauma, lead to infection and of course this will lead to longer days of stay. Modern nursing requires good skills in preventing skin injuries related to medical adhesives. Identification of patients at high risk of skin injury, determining appropriate steps and techniques for using and removing adhesive are needed in order to optimize nursing services. Key words: skin injury, medical adhesive"