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"This resource provides an integrated and comprehensive overview of modern approaches to drug lead discovery. Each chapter in this book reviews the theoretical background and application of a key technology in drug discovery, complemented by relevant case studies. The coverage includes the key approaches for drug design and discovery, high-throughput screening, fragment screening, multi-target drugs, de novo design, ADMET, natural products. This cutting-edge reference helps medicinal chemists in biotech, pharmaceutical, and other research contexts consider all possible avenues in starting their drug research programs."

"This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies."

"Gangguan penggunaan opioid merupakan suatu penyakit kronis dan kambuhan dengan konsekuensi ekonomi, personal, dan terhadap kesehatan masyarakat. Tingkat komorbiditas psikiatrik dan fisik ditemukan tinggi pada penggunaan opioid. Penggunaan rumatan buprenorfin jangka panjang telah terbukti dapat meningkatkan fungsi dan kualitas hidup pasien. Waktu minimal yang direkomendasi untuk mencapai manfaat klinik bagi pasien yaitu 12 bulan. Terlihat efek positif terapi berupa penurunan penggunaan opioid, perilaku berisiko terinfeksi HIV atau Hepatitis C, tindak kriminal dan mortalitas. Penelitian ini bertujuan untuk mengetahui hubungan psikopatologi, retensi dalam terapi dan kualitas hidup pasien terapi rumatan buprenorfin di RS. Ketergantungan Obat (RSKO) Jakarta. Penelitian dengan desain potong lintang pada bulan Maret-Mei 2019. Pengambilan sampel secara simple random sampling; menggunakan WHOQOL-BREF untuk menilai kualitas hidup serta SCL-90 untuk menilai psikopatologi. Retensi dalam terapi merupakan lamanya pasien mengikuti terapi buprenorfin, dibagi 2 kelompok yaitu ≤ 1 tahun dan > 1 tahun. Dari 105 sampel, mayoritas laki-laki, usia rerata 39 tahun, sudah menikah, tamat SMA, bekerja paruh waktu dan 40,9% memiliki psikopatologi. Ditemukan hubungan bermakna antara kualitas hidup dengan ada tidaknya psikopatologi pada pasien. Kualitas hidup ranah psikologik, hubungan sosial dan lingkungan secara signifikan lebih tinggi pada kelompok pasien tanpa psikopatologi. Temuan ini serupa dengan penelitian lainnya, yaitu terdapat hubungan antara psikopatologi dan kualitas hidup. 97,1% sampel memiliki retensi terapi > 1 tahun dengan rerata 4 tahun. Tidak ditemukan adanya perbedaan rerata kualitas hidup pasien pada masing-masing ranah yang dihubungkan dengan retensi dalam terapi, dengan p > 0,05. Hal ini dapat dipengaruhi oleh sedikitnya jumlah subjek penelitian pada kelompok retensi ≤ 1 tahun. Penelitian jangka panjang mengenai efektivitas terapi buprenorfin dengan sampel yang lebih besar dan beragam, khususnya terkait kepatuhan berobat perlu dilakukan sebagai studi lanjutan. Penelitian dengan keterlibatan jenis individu yang lebih beragam serta inklusi jenis adiksi lainnya perlu dilakukan sebagai studi lanjutan.

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Opioids use disorders are chronic relapsing diseases with many negative consequences on economic, personal, and public health. Psychiatric and general medical comorbidity were high among opioids users. Long term buprenorphine maintenance had been proven could increase patient's functioning and quality of life. Recommended length in order to achieve clinical benefits was 12 months. The overt positive impacts were decreases in frequency of using, high-risk using behavior, mortality, and criminal behavior. This cross-sectional study aimed to identify the relationship between psychopatology, retention in therapy, and quality of life of buprenorphine maintenance therapy patients in Jakarta Drug Dependence Hospital. The period of observation was on March to May 2019 to samples chosen by simple-random. The instruments used were WHOQOL-BREF and SCL-90, to measure quality of life and psychopatology, respectively. For treatment retention status sample were divided into 2 groups (the up-to-1-year group and the more-than-1-year group). Of the 105 samples, the majority were males with mean age of 39 y.o., married, high-school graduated, and part-timers, also 40.9% of them already had psychopatologies. There was a significant relationship between quality of life and the existance of psychopatology. Psychological and social and environmental relationship domains of quality of life were significantly higher on without-psychopatology group. This finding is similar to other studies whom found that there was a relationship between psychopatology and quality of life. Most samples (97.1%) had retained for at least more than 1 year in therapy, with average of 4 years. No difference in each domains of quality of life found between groups (p >0.05). This may be influenced by the small number of samples whom had retained for at least 1 year. Long-term study on buprenorphine therapy effectivity and medication adherence with more varied samples needs to be conducted."