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"Demonstrating that many useful resources, such as databases, can benefit most bioinformatics projects, the Handbook of Hidden Markov Models in Bioinformatics focuses on how to choose and use various methods and programs available for hidden Markov models (HMMs). The book begins with discussions on key HMM and related profile methods, including the HMMER package, the sequence analysis method (SAM), and the PSI-BLAST algorithm. It then provides detailed information about various types of publicly available HMM databases, such as Pfam, PANTHER, COG, and metaSHARK. After outlining ways to deve."

"Hidden Markov models (HMMs) are discrete-state, discrete-time, stochastic dynamical systems. They are often used to approximate systems with continuous state spaces operating in continuous time. In addition to introducing the basic ideas of HMMs and algorithms for using them, this book explains the derivations of the algorithms with enough supporting theory to enable readers to develop their own variants. The book also presents Kalman filtering as an extension of ideas from basic HMMs to models with continuous state spaces.Although applications of HMMs have become numerous (396,000 Google hits) since they emerged as the key technology for speech recognition in the 1980s, no introductory book on HMMs in general is available. This text aims to fill that gap.Hidden Markov Models and Dynamical Systems features illustrations that use the Lorenz system, laser data, and natural language data. The concluding chapter presents the application of HMMs to detecting sleep apnea in experimentally measured electrocardiograms. Algorithms are given in pseudocode in the text, and a working implementation of each algorithm is available on the accompanying website."