Hasil Pencarian  ::  Simpan CSV :: Kembali

"Latar Belakang. Data mengenai segmen plantar pada populasi belum banyak diteliti. Data ini penting sebagai penunjang epidemiologi dan dapat digunakan sebagai dasar penelitian lebih lanjut atau terapi jika terdapat kelainan segmen plantar.Tujuan. Tesis ini bertujuan untuk mengetahui profil plantar berupa lengkung kaki, perbedaan tekanan plantar kanan dan kiri dan tempat tekanan tertinggi di kaki.Metode. Penelitian ini menggunakan metode analitik observasional dengan instrumen penelitian berupa alat pemindai plantar yaitu MatScan.Hasil. Sebanyak 100 subjek sehat(50 laki-laki, 50 perempuan)ikut serta dalam penelitian ini dan didapatkan hasil: (1) proporsi lengkung kaki normal 89%, lengkung tinggi 7% dan lengkung rendah 4%;(2) uji Mann-Whitney dengan asumsi adanya perbedaan tekanan plantar kanan dan kiri memperlihatkan hasil p=0,954 (3) terdapat 5 tempat tekanan tertinggi pada plantar yang berpotensi menjadi ulkus.Kesimpulan. (1) proporsi lengkung kaki normal 89%, lengkung tinggi 7% dan lengkung rendah 4%;(2) tidak terdapat perbedaan tekanan yang bermakna pada kaki kanan da kaki kiri; dan (3) tempat titik tekanan tertinggi pada plantar terdapat di tumit, metatarsal II, metatarsal I, hallux dan basis os metatarsal V.

---

Background. There was not many research concerning plantar segment in the population an. This data is important to be epidemiological and data base for further reserach and therapy.Aims. This thesis was aimed to describe plantar profile : the foot arch, plantar difference of right and left foot and the peak of plantar ressure.Method. This research was used observational analytic method and Matscan plantar scanner as main instrument.Results. A hundred healthy subjects (50 males, 50 females) were participated in this study and the results were as follows: (1) the proportion of normal foot arch is 89% followed by high arch 7% and low arch 4%; (2) Mann-Whitney test was used in assumption that there is a difference between right and left plantar pressure shows p=0.954; (3) there is five peak area of plantar pressure that can lead to ulceration.Conclusion.(1) the proportion of normal foot arch in this research is 89% followed by high arch 7% and low arch 4%; (2) there is no plantar pressure difference between right and left foot; (3)the peak pressure area can be found in heel, bone of metatarsal II, bone of metatarsal I, thumb dan the base of metatarsal V."

"ABSTRAKPenelitian ini bertujuan untuk mendapatkan data pengaruh penghentian pajanan monosodium glutamat terhadap gambaran histologis tubuli seminiferi testis pada tikus putih (Rattus norvegicus) dewasa. Penelitian ini adalah penelitian eksperimental in vivo prospektif, menggunakan tikus putih (Rattus norvegicus) dewasa strain Sprague Dawley yang diberi msg dosis 4 g/kgBB dan 6 g/kgBB tiap hari selama 30 hari. Msg diberikan dengan dosis 4 g/kgBB dan 6 g/kgBB yang dilarutkan dalam aquades, masing-masing pada satu kelompok besar. Selain itu digunakan sekelompok besar tikus sebagai kelompok perlakuan yang hanya diberikan aquades. Perlakuan dilakukan dengan pemberian menggunakan sonde 1,5 ml aquades atau aquades 1,5 ml yang merupakan larutan msg sesuai dosis. Sehari, 14 hari dan 28 hari pasca penghentian pajanan, tikus disakrifikasi dan dilakukan pengamatan. Pengamatan dilakukan pada tubuli seminiferi testis, yaitu pada diameter tubuli seminiferi, jumlah spermatogonia, jumlah spermatosit dan jumlah spermatid. Penelitian ini menyimpulkan adanya perubahan (regenerasi) pada tubuli seminiferi, meskipun belum sampai pada keadaan seperti kontrol perlakuan. Data ini diharapkan dapat memberi informasi dan membuka kesempatan penelitian lanjut yang terkait dengan mekanisme regenerasi pasca kerusakan oleh monosodium glutamat.

---

ABSTRACTThe aim of this study was to analize histological appearance of testis after termination of msg exposure. Msg was given 4 g/kg BW and 6 g/kg BW soved ini aquadest. Each those treatment was given in two group of rats. This study also used a group of treatment control rat. The treatment was done by giving with sonde 1,5 ml aquadest or 1,5 ml aquadest with msg according the doses. The testis were isolated one day, 14 days and 28 days after termination of msg exposure; the rat were sacrificed and were examined the histological appearances of the testis. Spesificaly, the examination was done to tubuli seminiferi diameter, the amount of the spermatogonia, spermatocyts and spermatids. This study concluded that there was changed (regeneration) of the tubuli seminiferi, although not yet reach the situation in the control groups."

"Many health benefits have been attributed to selenium that include preventing various forms of cancer (e.g., colon cancer, prostate cancer, lung cancer and liver cancer), heart disease and other cardiovascular and muscle disorders, inhibiting viral expression, delaying the progression of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-positive patients, slowing the aging process, and having roles in mammalian development, including male reproduction and immune function. The purpose of the book is the same as the first two volumes which is to bring an up to date status of current research in the rapidly developing selenium field centered around the health benefits attributed to this element and how this element makes its way into protein."

"ABSTRAK>Latar Belakang: Selenium secara tidak langsung dapat berpengaruh pada kadar hemoglobin melalui fungsi proteksinya, namun tidak diketahui efeknya secara langsung pada bayi. Tujuan: Penelitian ini bertujuan mengetahui korelasi Kadar Selenium dengan Kadar Hemoglobin Bayi Usia 8-10 Bulan di Jakarta Pusat. Metode: Penelitian ini menggunakan desain cross-sectional yang dilakukan pada 75 sampel sesuai dengan kriteria penelitian. Kadar selenium dalam serum diukur dengan metode LC-MS/MS Liquid Chromatography ndash; Tandem Mass Spectrometry dan kadar hemoglobin diukur menggunakan HemoCue Hemoglobin system yang dilakukan oleh tenaga terlatih. Data penelitian dianalisis menggunakan uji Kolmogorov-Smirnov dan uji korelasi Pearson korelasi bermakna jika diperoleh p0,05. Kesimpulan: Dapat disimpulkan tidak terdapat korelasi bermakna antara kadar selenium dengan kadar hemoglobin bayi 8-10 bulan di Jakarta Pusat.

---

ABSTRACTBackground Selenium can indirectly influence haemoglobin levels by its protective function, but its effect is unknown on infants. Objective This study is aimed to observe the correlation between selenium levels and haemoglobin levels on 8 to 10 months old infants in Central Jakarta. Method This study applies the crosssectional design which was conducted on 75 samples based on study criteria. Selenium levels were measured by LC MS MS Liquid Chromatography ndash Tandem Mass Spectrometry method and haemoglobin levels were assessed using HemoCue Hemoglobin system by trained personnel. The data was analyzed with KolmogorovSmirnov test and Spearman correlation test significant correlation if p0.05 . Discussion In conclusion, there was no significant correlation between selenium levels and haemoglobin levels on 8 to 10months old infants in Central Jakarta. p 0.53."

"Latar belakang: Pitiriasis versikolor (PV) merupakan infeksi jamur superfisial kronik dengan prevalensi tinggi. Belum ada data yang membandingkan sampo SeS2 1,8% dengan ketokonazol 2% pada terapi PV. Tujuan: Mengetahui efikasi mikologis, keamanan, kekambuhan, dan efikasi biaya antara sampo selenium sulfida 1,8% dibandingkan dengan ketokonazol 2% pada PV. Metode: Uji klinis acak tersamar ganda terhadap pasien PV bulan September hingga Desember 2018, dengan terapi sampo SeS2 1,8% atau ketokonazol 2% sesuai dengan alokasi random. Dilakukan pemeriksaan fisik, uji provokasi skuama, lampu Wood, dan kalium hidroksida. Efikasi mikologis dianalisis dengan intention to treat dan kekambuhan dengan analisis per-protokol. Efikasi biaya dengan menghitung Incremental Cost-Effectiveness Ratio (ICER). Hasil: Efikasi mikologis lebih tinggi pada ketokonazol 2%, yaitu sebesar 94% vs 86%, tetapi tidak berbeda secara statistik (RR=2,3(95%IK0,6-8,5), p=0,182). Efek samping pada ketokonazol 2% lebih tinggi, yaitu 22% vs 8%. SeS2 1,8% lebih murah 14.880 rupiah, dengan risiko KOH masih positif sebesar 8% lebih tinggi dibanding ketokonazol 2%. Kekambuhan sebulan didapatkan lebih besar pada SeS2 1,8%, yaitu sebesar 8% vs 14%. Kesimpulan: Tidak terdapat perbedaan efikasi mikologis, efek samping, dan kekambuhan sebulan, antara SeS2 1,8% dengan ketokonazol 2%. Penggunaan SeS2 1,8% pada terapi PV lebih murah dengan risiko gagal terapi lebih tinggi dibandingkan ketokonazol 2%.

---

Background: Pityriasis versicolor (PV) is a chronic superficial fungal infection which highly prevalent. There is no data comparing SeS2 1.8% with 2% ketoconazole shampoo in the treatment of PV. Objective: To assess the mycological efficacy, safety, relaps, and cost-efficacy of SeS2 1.8% and ketoconazole 2% shampoo for the treatment of PV. Methods: A double blind randomized controled trial was performed in patients with PV during September-December 2018, based on block randomization. Physical examinations, scale provocation test, Woods lamp and potassium hydroxide examination were conducted. Intention to treat analysis was performed to evaluated mycological efficacy and per-protocol analysis to evaluated relaps. Cost-efficacy was analyzed by calculating the Incremental Cost-Effectiveness Ratio (ICER). Result: The mycological efficacy, side effect and relaps were higher in the ketoconazole group; 94% vs 86% (RR=2.3(95%CI 0.6-8.5), p= 0.182), 22% versus 8%, and 14% versus 8%. We found lesser cost for SeS2 1.8% of about 14.880 rupiah with risk of persistent positive KOH smear is 8% higher than ketoconazole. Conclusion: There were no significant differences of mycological efficacy, side effect, and relaps, between both arms. The cost-efficacy revealed a lesser cost for SeS2 1.8% with higher risk of persistent positive KOH as compared to ketoconazole."

"Cedera iskemia reperfusi (CIR) berperan pada patofisiologi sejumlah besar penyakit diantaranya Acute limb ischemia (ALI). Kerusakan yang terjadi dapat bersifat lokal, tetapi juga dapat berefek sistemik yaitu kerusakan organ jauh seperti paru-paru. Kerusakan paru-paru yang terjadi akibat CIR merupakan mekanisme kompleks yang melibatkan pembentukan Reactive oxygen species (ROS), mediator inflamasi dan aktivasi neutrofil. Salah satu strategi untuk mengurangi kerusakan yang terjadi adalah dengan pemberian antioksidan. Selenium merupakan komponen penting dari enzim antioksidan, Glutation peroksidase (GPx) yang dapat mengikat ROS sehingga sel terlindungi dari kerusakan. Tujuan dari penelitian ini adalah untuk membandingkan derajat kerusakan paru-paru akibat CIR tungkai pada tikus Sprague-Dawley (SD) yang diberikan selenium dengan yang tidak diberikan selenium. Penelitian eksperimental ini dilakukan di Rumah Sakit Hewan Pendidikan, Fakultas kedokteran hewan, IPB dan Departemen Patologi Anatomi RSCM, Fakultas Kedokteran UI. Lima belas tikus SD dibagi menjadi 3 kelompok yaitu kelompok kontrol atau iskemia reperfusi tanpa pemberian selenium (A), kelompok yang dilakukan iskemia, diberikan selenium lalu direperfusi (B) dan kelompok yang dilakukan iskemia, direperfusi lalu diberikan selenium (C). Iskemia pada semua hewan coba dilakukan selama 2 jam dengan meligasi a. femoralis komunis bilateral dan reperfusi dilakukan selama 3 jam. Dosis selenium yang diberikan yaitu 0,2mg/kgBB secara intravena. Setelah dilakukan reperfusi, hewan coba dikorbankan, jaringan paru-paru direseksi dan dilakukan analisis histopatologik. Pada kelompok A, median derajat kerusakan paru-paru adalah berat, kelompok B adalah ringan dan kelompok C adalah sedang (p=0,015). Dilakukan analisis post hoc, didapatkan perbedaan bermakna gambaran histopatologik kelompok A dibanding kelompok B (p=0,011) dan kelompok A dibanding kelompok C (p=0,031), sedangakan perbandingan antara kelompok B dan kelompok C tidak berbeda bermakna (p=0,221). Sebagai kesimpulan, pemberian selenium dapat menurunkan derajat kerusakan jaringan paru-paru akibat CIR tungkai pada tikus SD.

---

Ischemia-reperfusion injury (IRI) plays an important role in the pathophysiology of a large number of diseases including Acute limb ischemia (ALI). IRIs damage can occur locally, but also systemic to distant organs such as the lung. Lung damage caused by IRI is a complex mechanism that involves the formation of Reactive oxygen species (ROS), inflammatory mediators and neutrophil activation. One strategy to reduce the damage is administering antioxidant therapy. Selenium is a component of the antioxidant enzyme, Glutathione peroxidase (GPx), which can bind ROS and protect the cell.

The aim of this study to compare the degree of lung injury due to ischemia-reperfusion limb in Sprague-Dawley (SD) rats given selenium with those not. This experimental study was conducted at the Animal Hospital, Faculty of Veterinary Medicine, IPB and the Department of Pathology Anatomy RSCM, Faculty of Medicine Universitas Indonesia. Fifteen Sprague-Dawley male rats were divided randomly into 3 groups: group ischemia-reperfusion or control (A), group ischemia-reperfusion with selenium before reperfusion (B) and group ischemia-reperfusion with selenium after reperfusion (C). All animals were undergone 2 hours of ischemia by occlusion femoral artery and 3 hours of reperfusion. Selenium was given IV at a dose of 0.2 mg/kg.

After reperfusion, all animals were euthanized and the lung tissue harvested for histopathological analysis. In group A, the median degree of lung injury was severe, group B was mild and group C was moderate (p = 0.015). Post hoc analysis was performed, there was a significant difference between group A compared to group B (p = 0.011) and group A compared to group C (p = 0.031), while the comparison between group B and group C was not significantly different (p = 0.221). In conclusion, the administration of selenium significantly decreases lung injury induced by limb ischemia-reperfusion in SD rats."

"Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development."