Hypertrophic obstructive cardiomyopathy (HOCM) is a genetic disorder associated with significant morbidity and mortality. Patients with this illness are prone to sudden death, angina, syncope, and heart failure. Symptomatic patients with HOCM are usually medically treated; in the few patients with persistent symptoms, surgical myomectomy offers satisfactory control.1'1 The role of DDD pacing in effort to reduce left ventricular outflow tract (LVOT) gradient is still controversial.3-4 Recently, non-surgical septal reduction therapy (NSRT) has gained popularity as an alternative to surgery, because the procedure is much simpler, safe and effective for relief of symptoms of LVOT obstruction.5 7This paper will report a case of HOCM successfully treated with NSRT.