Latar belakang: Melasma merupakan kelainan hiperpigmentasi didapat yangdisebabkan disfungsi melanogenesis, berupa makula coklat kehitaman simetris,terutama mengenai area wajah. Patogenesis melasma belum diketahui dengan jelas,beberapa faktor yang diduga berperan, di antaranya disfungsi tiroid dan defisiensi seng.Tujuan: Mengetahui kadar seng serum pada pasien melasma dan nonmelasma dengandan tanpa disfungsi tiroid.Metode: Sebuah penelitian dengan desain potong lintang dilakukan di Jakarta padaSeptember-Desember 2019. Terdapat 60 pasien melasma dan 60 pasien nonmelasma.Kedua kelompok dilakukan matching usia dan jenis kelamin. Atomic absorptionspectrophotometry digunakan untuk mengukur kadar seng serum. Laboratorium darahuntuk memeriksa fungsi tiroid (TSH dan FT4). Analisis statistik menggunakan softwareSPSS.Hasil: Rerata kadar seng serum pada kelompok melasma 10,25±1,89 μmol/L dannonmelasma adalah 10,29±1,46 μmol/L (p <0,901). Rerata kadar seng serum padapasien melasma dengan disfungsi tiroid 8,77±0,69, melasma tanpa disfungsi tiroid10,33±1,89, nonmelasma dengan disfungsi tiroid 10,48±2,4, dan nonmelasma tanpadisfungsi tiroid 10,27±1,4 (p <0,184).Kesimpulan: Tidak didapatkan perbedaan bermakna antara kadar seng serum padakelompok melasma dan nonmelasma dengan dan tanpa disfungsi tiroid.

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Background: Melasma is an acquired hyperpigmentation disorder, clinically as

asymmetrical blackish brown macules, especially on the facial area. Several factors are

thought to play a role, including thyroid dysfunction and zinc deficiency.

Objective: To determine serum zinc levels in melasma and non-melasma patients with

and without thyroid dysfunction.

Methods: A cross-sectional study was conducted in Jakarta in September-December

2019. There were 60 melasma patients and 60 non-melasma patients. The two groups

were matched for age and sex. Atomic absorption spectrophotometry was used to

measure serum zinc levels. Blood laboratory was used to check thyroid function (TSH

and FT4). Statistical analysis was done by SPSS software.

Results: The mean serum zinc level in the melasma group was 10.25 ± 1.89 μmol / L

and non-melasma was 10.29 ± 1.46 μmol / L (p <0.901). The mean serum zinc level in

melasma patients with thyroid dysfunction was 8.77 ± 0.69, melasma without thyroid

dysfunction 10.33 ± 1.89, non-melasma with thyroid dysfunction 10.48 ± 2.4, and nonmelasma

without thyroid dysfunction 10.27 ± 1.4 (p <0.184).

Conclusions: There was no significant difference between serum zinc levels in the

melasma and non-melasma groups with and without thyroid dysfunction.