Two flavonoid compounds, 5,7,3?,4?-tetrahydroxy-6-geranylflavonol (1) and kaempferol 7-O-β-glucose (2) have been
isolated from the leaves of Macaranga hispida (Blume), Mull.Arg. Isolation and purification were conducted by
chromatography methods and chemical structure characterization was carried out by spectroscopic methods. The
5,7,3?,4?-tetrahydrxyi-6-geranyl flavonol (1) and kaempferol 7-O-glucose (2) had moderate cytotoxic activity against
murine leukemia P-388 cell lines with IC50 value of 0.22 and 101.5 μg/mL, respectively. The IC50 for antioxidant
activities of (1) and (2) were 2.83 and 13.95 μg/mL, respectively. The LC50 of (1) and (2) from BSLT were 350 and
>1000 μg/mL, respectively.
Identifikasi dan Studi Bioaktifitas Senyawa Flavonoid dari Macaranga hispida (Blume) Mull.Arg. Dua senyawa
flavonoid, 5,7,3?,4?-tetrahidroksi-6-geranilflavonol (1) dan kaemferol 7-O-β-glukosa (2) telah diisolasi dari daun
Macaranga hispida (Blume) Mull. Arg. Isolasi dan pemurnian dilakukan dengan metode kromatografi dan karakterisasi
struktur kimia dilakukan dengan metode spektroskopi. 5,7,3', 4'-tetrahidroksi-6-geranil flavonol (1) kaemferol 7-Oglukosa
(2) memiliki aktivitas sitotoksik sel murine leukemia P-388 dengan nilai IC50 masing-masing 0,22 dan 101,5
μg/mL. Aktivitas antioksidan (1) dan (2) dinyatakan dengan nilai IC50 masing-masing sebesar 2,83 dan 13,95 μg/mL.
Nilai LC50 dengan uji BSLT (1) dan (2) masing-masing 350 dan >1000 μg/mL.
