ABSTRAKA laboratory experimental study conducted on antimicrobial effects of Coleus amboinicus. Lour concentrate towards Candida albicans on acrylic resin. Samples of this study are 10x10x1 mm heat cured acrylic plates immersed in 15%, 12.5%, 10%, 7.5% of Coleus amboinicus. Lour concentrate solution. Sterilized aquadest was used as control. 16 samples were used for each exercise. Statistical analyses used are One-way Anova and LSD with 5% significance degree. The results showed that increasing Coleus amboinicus. Lour concentrate solution i.c. 7.5%, 10%, 12.5%, 15% will increased the antimicrobial effects towards Candida Albicans. The most effective concentrate solution in reducing Candida albicans colonies is 15%.