Filariais is a tropical disease , which is caused by microfilaria of filarial worm and is spread by mosquitoes bites and shows acute or chronic clinical manifestation. Therefore, this disease becomes one of national priority to eradicate infectious diseaseand listed as medium-term National development plan 2010 --2014. Mass-drug administration (MDA) program for filariasis has been done in Depok since 2008. Yet, there are still gap in realization of mass drug administration for prevent filariasis in Sukmajaya and Tirtajaya and there had never been done any researches about this program before. Now, we're doing a research about relationship between implementation of drug distribution with mass drug administration coverage to prevent filariasis. This research is used consecutive sampling cross sectional methode with questionnaire in target population with CI 95%. In the results we know the p value is more than 0,05 in both village. So there are no relation between implementation of drug distribution with mass drug administration coverage to prevent filariasis. Implementation of mass-drug administration distribution to prevent filariasis using standard operational number at Tirtajaya is 5.7% and Sukmajaya 7%. So that, drug coverage number is also low. Thus, in the next research it is suggested to distributing mass drug administration to prevent filariasis based on standard operational then the similar research done later.