Proton pump inhibitors (PPls) are the most effective anti secretory drugs available for controlling gastricacid acidity and volume. They are the drug of choice in the treatment for gastro esophageal reflux disease(GERD), Helicobacter pylori eradication, peptic ulcer and non steroidal anti-inflammatory drug (NSAID)gastropathy. For acute cases, on intravenous PPI is needed, especially for hospitalized patient. Recently,intravenous pantoprazole represents an alternative to intravenous histamine-2 receptor antagonists. Weobserved 2 patients who were treated with pantoprazole for duodenal ulcer; where one case had acomplication of bleeding with a history of long term use of NSAID. After two weelrs of treatment withpantoprazole, significant lesion healing from endoscopy findings was achieved in both cases.